Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signaling

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Survival and Clinicopathological Significance of SIRT1 Expression in Cancers: A Meta-Analysis

(2019) Min Sun et al.   Frontiers in Endocrinology

Receptor tyrosine kinase recepteur d'origine nantais as predictive marker for aggressive prostate cancer in African Americans

(2019) Roble G. Bedolla et al.   MOLECULAR CARCINOGENESIS

CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis

(2019) Michael A. Augello et al.   CANCER CELL

Next-generation characterization of the Cancer Cell Line Encyclopedia

(2019) Mahmoud Ghandi et al.   NATURE

Integrating resistance functions to predict response to induction chemotherapy in de novo acute myeloid leukemia

(2019) Yu‐Chiao Chiu et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Suppression of ribosomal protein RPS6KB1 by Nexrutine increases sensitivity of prostate tumors to radiation

(2018) Suleman S. Hussain et al.   CANCER LETTERS

SIRT1 is a transcriptional enhancer of the glucocorticoid receptor acting independently to its deacetylase activity

(2018) Shigeru Suzuki et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

P53 enhances apoptosis induced by doxorubicin only under conditions of severe DNA damage

(2018) Ru-Wei Lin et al.   CELL CYCLE

SIRT1 contributes to neuroendocrine differentiation of prostate cancer

(2017) Lin Ruan et al.   Oncotarget

The UCA1/miR-204/Sirt1 axis modulates docetaxel sensitivity of prostate cancer cells

(2016) Xu Wang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Drug discovery in advanced prostate cancer: translating biology into therapy

(2016) Timothy A. Yap et al.   NATURE REVIEWS DRUG DISCOVERY

Crosstalk between RON and androgen receptor signaling in the development of castration resistant prostate cancer

(2016) Izhar Batth et al.   Oncotarget

The Role of SIRT1 in Cancer

(2015) Melissa J. Wilking et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss of Sirt1 Promotes Prostatic Intraepithelial Neoplasia, Reduces Mitophagy, and Delays Park2 Translocation to Mitochondria

(2015) Gabriele Di Sante et al.   AMERICAN JOURNAL OF PATHOLOGY

An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease

(2015) Sigurd D. Süssmuth et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The Molecular Taxonomy of Primary Prostate Cancer

(2015) Adam Abeshouse et al.   CELL

Bim directly antagonizes Bcl-xl in doxorubicin-induced prostate cancer cell apoptosis independently of p53

(2015) Min-Chi Yang et al.   CELL CYCLE

Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism

(2015) Seung Min Jeong et al.   MOLECULES AND CELLS

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Combined Targeting of STAT3/NF-κB/COX-2/EP4 for Effective Management of Pancreatic Cancer

(2014) Jingjing Gong et al.   CLINICAL CANCER RESEARCH

The Many Faces of Sirtuins: Coupling of NAD metabolism, sirtuins and lifespan

(2014) Eric Verdin   NATURE MEDICINE

CFS-1686 Causes Cell Cycle Arrest at Intra-S Phase by Interference of Interaction of Topoisomerase 1 with DNA

(2014) Ru-Wei Lin et al.   PLoS One

High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients

(2014) Xiaojing Chen et al.   Scientific Reports

SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer

(2014) Akira Noguchi et al.   Cancer Medicine

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Quantitative Study of the Elastic Modulus of Loosely Attached Cells in AFM Indentation Experiments

(2013) Maxim E. Dokukin et al.   BIOPHYSICAL JOURNAL

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Sirtuin-1 Regulates Acinar-to-Ductal Metaplasia and Supports Cancer Cell Viability in Pancreatic Cancer

(2013) E. Wauters et al.   CANCER RESEARCH

Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation

(2013) Brendan C. Dickson et al.   HUMAN PATHOLOGY

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Dietary Resveratrol Prevents Development of High-Grade Prostatic Intraepithelial Neoplastic Lesions: Involvement of SIRT1/S6K Axis

(2012) G. Li et al.   Cancer Prevention Research

Seminal plasma proteins in prostatic carcinoma: increased nuclear semenogelin I expression is a predictor of biochemical recurrence after radical prostatectomy

(2012) Koji Izumi et al.   HUMAN PATHOLOGY

Aberrant Cytoplasm Localization and Protein Stability of SIRT1 is Regulated by PI3K/IGF-1R Signaling in Human Cancer Cells

(2012) Vanessa Byles et al.   International Journal of Biological Sciences

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency

(2012) D Herranz et al.   ONCOGENE

SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis

(2012) V Byles et al.   ONCOGENE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

(2011) Brett S. Carver et al.   CANCER CELL

Disruption of a Sirt1-Dependent Autophagy Checkpoint in the Prostate Results in Prostatic Intraepithelial Neoplasia Lesion Formation

(2010) M. J. Powell et al.   CANCER RESEARCH

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Involvement of FLIP in 2-Methoxyestradiol-Induced Tumor Regression in Transgenic Adenocarcinoma of Mouse Prostate Model

(2009) M. Ganapathy et al.   CLINICAL CANCER RESEARCH

Expression and prognostic significance of SIRT1 in ovarian epithelial tumours

(2009) Kyu Yun Jang et al.   PATHOLOGY

The use of flat punch indentation to determine the viscoelastic properties in the time and frequency domains of a soft layer bonded to a rigid substrate

(2008) Y CAO et al.   Acta Biomaterialia

A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells

(2008) Keitaro Kojima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of Sirtuin Histone Deacetylase SIRT1 in Prostate Cancer

(2008) Brittney Jung-Hynes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deacetylation of cortactin by SIRT1 promotes cell migration

(2008) Y Zhang et al.   ONCOGENE