Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in KRAS and BRAF Tumor Cells

Relevance of mortalin to cancer cell stemness and cancer therapy

(2017) Chae-Ok Yun et al.   Scientific Reports

Stress Chaperone Mortalin Contributes to Epithelial-to-Mesenchymal Transition and Cancer Metastasis

(2016) Y. Na et al.   CANCER RESEARCH

Alternative modes of client binding enable functional plasticity of Hsp70

(2016) Alireza Mashaghi et al.   NATURE

ERK1/2 can feedback-regulate cellular MEK1/2 levels

(2015) Seung-Keun Hong et al.   CELLULAR SIGNALLING

Sp1 regulates Raf/MEK/ERK-induced p21CIP1 transcription in TP53-mutated cancer cells

(2015) Mansi Karkhanis et al.   CELLULAR SIGNALLING

Active ERK2 is sufficient to mediate growth arrest and differentiation signaling

(2015) Pui-Kei Wu et al.   FEBS Journal

A Functional DnaK Dimer Is Essential for the Efficient Interaction with Hsp40 Heat Shock Protein

(2015) Evans Boateng Sarbeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

(2015) Agnieszka K. Witkiewicz et al.   Nature Communications

Hsp70 Forms Antiparallel Dimers Stabilized by Post-translational Modifications to Position Clients for Transfer to Hsp90

(2015) Nina Morgner et al.   Cell Reports

Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells

(2014) D Starenki et al.   ONCOGENE

Crystal Structure of the Stress-Inducible Human Heat Shock Protein 70 Substrate-Binding Domain in Complex with Peptide Substrate

(2014) Pingfeng Zhang et al.   PLoS One

Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone

(2014) Joseph Amick et al.   PROTEIN SCIENCE

Elevated levels of mitochondrial mortalin and cytosolic HSP70 in blood as risk factors in patients with colorectal cancer

(2013) Perri Rozenberg et al.   INTERNATIONAL JOURNAL OF CANCER

Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition

(2013) JING CHEN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A Mortalin/HSPA9-Mediated Switch in Tumor-Suppressive Signaling of Raf/MEK/Extracellular Signal-Regulated Kinase

(2013) P.-K. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural basis for protein phosphatase 1 regulation and specificity

(2012) Wolfgang Peti et al.   FEBS Journal

The PP1 binding code: a molecular-lego strategy that governs specificity

(2012) Ewald Heroes et al.   FEBS Journal

The human phosphatase interactome: An intricate family portrait

(2012) Francesca Sacco et al.   FEBS LETTERS

N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence

(2012) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mortalin–p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy

(2011) W-J Lu et al.   CELL DEATH AND DIFFERENTIATION

Signal control through Raf: in sickness and in health

(2011) Jihan K Osborne et al.   CELL RESEARCH

Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanoma

(2011) Daxin Sun et al.   MELANOMA RESEARCH

How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

(2010) Yohannes Mebratu et al.   CELL CYCLE

Jailbreak: Oncogene-induced senescence and its evasion

(2010) Fiona K.E. MDuff et al.   CELLULAR SIGNALLING

Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 interaction using purified proteins - Identification of additional interacting regions

(2010) Ohad Iosefson et al.   FEBS LETTERS

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Magnetic nanoparticle-based isolation of endocytic vesicles reveals a role of the heat shock protein GRP75 in macromolecular delivery

(2010) A. Wittrup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

Noncatalytic Function of ERK1/2 Can Promote Raf/MEK/ERK-mediated Growth Arrest Signaling

(2009) Seung-Keun Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt3 and Mutant V600EB-Raf Cooperate to Promote Early Melanoma Development

(2008) M. Cheung et al.   CANCER RESEARCH

Functional Copy-Number Alterations in Cancer

(2008) Barry S. Taylor et al.   PLoS One