Article
Engineering, Multidisciplinary
Hui Ren, Zhen Zhang, Kailun Lu, Yuanyuan Shen, Chaoliang He, Xuesi Chen
Summary: This study developed a hydrogel dressing that can adapt to burn wounds and loaded with drugs, showing good antioxidant properties and promoting wound healing.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2023)
Article
Engineering, Biomedical
Longbao Feng, Yu Liu, Yini Chen, Qi Xiang, Yadong Huang, Zonghua Liu, Wei Xue, Rui Guo
Summary: This study developed a biomaterial called RQLAg hydrogel, which has antibacterial and wound-healing properties. By fusing silver nanoparticles with antibacterial properties and asiaticoside-loaded liposomes with anti-inflammatory/vascularization effects into a hydrogel with a special porous structure, the hydrogel shows sustained release capabilities of silver ions and asiaticoside, as well as concentration-dependent swelling properties, pore size, and compressive strength. Cellular experiments demonstrate that the hydrogel has good cell compatibility and promotes cell migration, angiogenesis, and M1 macrophage polarization. In addition, the hydrogel exhibits excellent antibacterial activity against Escherichia coli and Staphylococcus aureus. In vivo experiments on rats show that the RQLAg hydrogel efficiently promotes wound healing and has stronger healing promoting abilities compared to Aquacel Ag. In summary, the RQLAg hydrogel is expected to be an excellent material for accelerating open wound healing and preventing bacterial infections.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Jinfeng Cao, Ping Wu, Qianqian Cheng, Chen He, Yun Chen, Jinping Zhou
Summary: A new type of injectable CMCh hydrogel wound dressing with self-healing properties is constructed using coordination bonds and alkali/urea aqueous solutions. The hydrogel exhibits self-healing, self-adaption, and thermoresponsive ability, significantly accelerating skin tissue regeneration and wound closure. It has great potential in tissue engineering applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Chuang Li, Tao Jiang, Cong Zhou, Ankang Jiang, Cuifen Lu, Guichun Yang, Junqi Nie, Feiyi Wang, Xiaofan Yang, Zhenbing Chen
Summary: Promoting the healing of diabetic wounds is a major challenge, but Chitosan-based POSS-PEG hybrid hydrogels show excellent healing properties with strong mechanical strength, self-healing efficiency, cytocompatibility, and antibacterial properties.
CARBOHYDRATE POLYMERS
(2023)
Article
Biotechnology & Applied Microbiology
Chuwei Zhang, Qingrong Zhang, Dongmei Yang, Yating Qiao, Bolin Wang, Jun Yan, Zihan Li, Zhanghao Huang, Youlang Zhou, Kesu Hu, Yi Zhang
Summary: Burns can impair skin barrier function and have high mortality rates. Chitooligosaccharides (COS) have potential in burn wound therapy by promoting wound healing through regulation of the MAPK pathway and HGF.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Health Care Sciences & Services
Juin-Hong Cherng, Cheng-An J. Lin, Cheng-Che Liu, Jue-Zong Yeh, Gang-Yi Fan, Hsin-Da Tsai, Chun-Fang Chung, Sheng-Der Hsu
Summary: Chitosan and gold nanoparticles (AuNPs) dressings have been shown to effectively promote burn wound healing and reduce infection and inflammation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Engineering, Environmental
Meng Li, Yongping Liang, Yuqing Liang, Guoying Pan, Baolin Guo
Summary: Researchers have developed an injectable adhesive self-healing photothermal hydrogel that can adapt to frequent movement wounds and promote healing, while also preventing and treating wound infections.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Badriyah Shadid Alotaibi, Maryam Shoukat, Manal Buabeid, Abida Kalsoom Khan, Ghulam Murtaza
Summary: The use of neomycin-loaded CG/PAN/PU nanofibers can promote wound healing, especially in burn wounds, indicating great potential in this field.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Ziyan Wan, Jiahui He, Yutong Yang, Tie Chong, Jiaxin Wang, Baolin Guo, Li Xue
Summary: The study designed a series of injectable adhesive multifunctional biocompatible hydrogels with hemostasis, wound management, and anti-adhesion properties for nephron-sparing surgeries. Results demonstrated that the hydrogel showed excellent hemostasis and wound healing properties in liver injury and nephron-sparing surgery models, with effective anti-adhesion performance in an abdomen-caecum adhesion model.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Lingshuang Wang, Lian Duan, Ga Liu, Jianfeng Sun, Mohammad-Ali Shahbazi, Subhas C. C. Kundu, Rui L. L. Reis, Bo Xiao, Xiao Yang
Summary: Polyacrylic acid (PAA) and its derivatives are commonly used as matrices in wound dressings, but their weak wet adhesion limits their clinical application. In this study, a PAA-based coacervate hydrogel with strong wet adhesion capability is created by mixing PAA copolymers with isoprenyl oxy poly(ethylene glycol) ether and tannic acid. The coacervate exhibits solid adhesion to both dry and wet substrates, with an adhesive strength to skin of 23.4 kPa and 70% adhesion underwater. It also possesses desirable self-healing and extensible properties, making it suitable for joints that undergo frequent movement. The coacervate demonstrates antibacterial activity, facilitates fibroblast migration, modulates macrophage polarization, shortens hemostatic time, and promotes collagen deposition, angiogenesis, and epithelialization, suggesting its promising potential as a wound dressing in medical translation.
Article
Engineering, Environmental
Meng Luo, Min Wang, Wen Niu, Mi Chen, Wei Cheng, Long Zhang, Chenxi Xie, Yidan Wang, Yi Guo, Tongtong Leng, Xingxing Zhang, Cai Lin, Bo Lei
Summary: A study has developed an injectable self-healing anti-inflammatory, angiogenic europium oxide nanorods reinforced nanocomposites dressing, which demonstrated excellent wound healing and skin regeneration effects in experiments.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Jinze Lan, Lianxin Shi, Wuyi Xiao, Xiaobin Zhang, Shutao Wang
Summary: A self-pumping organohydrogel dressing with hydrophilic fractal microchannels is developed, which can rapidly drain excessive exudates and promote burn wound healing. This dressing significantly reduces dermal cavity, accelerates blood vessel and hair follicle regeneration compared with commercial dressings.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jinze Lan, Lianxin Shi, Wuyi Xiao, Xiaobin Zhang, Shutao Wang
Summary: This study presents a self-pumping organohydrogel dressing with hydrophilic fractal microchannels that effectively promotes burn wound healing. In a murine burn wound model, the dressing reduces dermal cavity by approximately 42.5%, accelerates blood vessel regeneration by approximately 6.6 times, and hair follicle regeneration by approximately 13.5 times compared to a commercial dressing (Tegaderm).
ADVANCED MATERIALS
(2023)
Article
Polymer Science
Kai-Yi Chang, Ying-Nien Chou, Wei-Yu Chen, Chuh-Yean Chen, Hong-Ru Lin
Summary: This study develops a multi-functional hydrogel with a dual injection system based on the adhesive and self-healing properties of the byssus excretion found in mussels. The hydrogel has high strength, temperature sensitivity, good adhesion, self-healing properties, and antibacterial resistance. It can be used for deep wound treatment and improvement of traditional wound dressings.
Article
Biochemistry & Molecular Biology
Hanwen Jiang, Yan Xiao, Huanxuan Huang, Wang Yin, Meidong Lang
Summary: An antibacterial hydrogel with injectability, self-healing ability, and tissue adhesion was prepared by mixing mixed charged polypeptides and oxidized dextran. The hydrogel exhibited high-efficient antibacterial activity against E. coli and S. aureus with excellent biocompatibility.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.