Article
Biochemistry & Molecular Biology
Bruna de Souza Lima, Ana Paula Varela Sanches, Maira Schuchter Ferreira, Josilene Lopes de Oliveira, Jane K. Cleal, Leticia Ignacio-Souza
Summary: Maternal obesity can have an impact on the health of offspring, particularly during critical periods. Studies have shown that diet and nutritional status play a crucial role in fetal outcomes and placental development. Specifically, a high-fat diet can be considered as a nutritional insult that impairs the maternal-placental axis, thus affecting offspring development and outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Ana Paula Varela Sanches, Josilene Lopes de Oliveira, Maira Schuchter Ferreira, Bruna de Souza Lima, Josiane Erica Miyamoto, Lais Angelica de Paula Simino, Marcio Alberto Torsoni, Adriana Souza Torsoni, Marciane Milanski, Leticia Ignacio-Souza
Summary: The aim of this study was to investigate the parameters of maternal-fetal outcomes in a diet-induced obesity model. Females who were obese and glucose intolerant prior to pregnancy had lower placental efficiency and lower birth weight pups compared to the controls. The study found that maternal obesity disrupts the proportionality between maternal and fetal outcomes during pregnancy, which could be due to hormonal signaling issues and inflammation in the maternal metabolic environment. Maternal obesity also alters placental thickness, fatty acid transport, and the expression of growth factors. Lower expression of epidermal growth factor receptor (EGFR) mRNA in obese mothers may have contributed to placental rupture and adverse fetal outcomes. Maintaining maternal glucose homeostasis and overexpression of placental growth factor (PGF) likely protected the placenta and fetuses from damage.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Agriculture, Dairy & Animal Science
Jessica G. Syring, Matthew S. Crouse, Tammi L. Neville, Alison K. Ward, Carl R. Dahlen, Lawrence P. Reynolds, Pawel P. Borowicz, Kyle J. McLean, Bryan W. Neville, Joel S. Caton
Summary: This study investigated the correlation between concentrations of B-12 and folate in maternal serum, allantoic fluid, and amniotic fluid, and concentrations of methionine-folate cycle intermediates in fetal fluids, as well as fetal hepatic gene expression. The study found that restricted maternal nutrition resulted in increased B-12 and folate concentrations in allantoic fluid, as well as altered gene expression in fetal liver. These findings contribute to our understanding of the effects of restricted maternal nutrition on fetal programming and can help in the development of strategic supplementation plans for beef cattle.
JOURNAL OF ANIMAL SCIENCE
(2023)
Review
Nutrition & Dietetics
Izabela Michonska, Edyta Luszczki, Magdalena Zielinska, Lukasz Oleksy, Artur Stolarczyk, Katarzyna Deren
Summary: Childhood obesity and associated diseases are major problems in modern medicine and public health. The impact of these issues extends beyond the present and immediate future, affecting long-term adult health. Nutritional programming theory explores how a child's birth weight, influenced by maternal feeding behavior, relates to diseases such as heart disease, diabetes, dyslipidemia, and hypertension. This narrative review provides an overview of the history, theory, and prenatal mechanisms of nutritional programming in relation to childhood obesity and other metabolic diseases.
Article
Genetics & Heredity
Yang Liu, Qiyue Ding, Steven J. Halderson, Sebastian I. Arriola Apelo, Amanda K. Jones, Sambhu M. Pillai, Maria L. Hoffman, Sarah Reed, Kristen E. Govoni, Steven A. Zinn, Wei Guo
Summary: Overfeeding during gestation can have long-lasting effects on offspring autophagy signaling, especially in later developmental stages and female offspring. Targeting autophagy pathways may be a strategy to mitigate the adverse effects in offspring of over-fed ewes.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Anais Serati, Chiara Novielli, Gaia Maria Anelli, Maria Mandalari, Francesca Parisi, Irene Cetin, Renata Paleari, Chiara Mando
Summary: Maternal obesity and gestational diabetes mellitus (GDM) are associated with adverse maternal and foetal outcomes, and involve epigenetic alterations contributing to the pathogenesis of metabolic diseases. This pilot study analyzed plasma microRNAs in obese pregnant women with/without GDM, revealing differentially expressed microRNAs related to oxidative stress, inflammation, nutrients, and hormones metabolism. These findings provide insight into the complex epigenetic network regulating metabolic pathways in MO and GDM, but further investigations are needed.
Article
Nutrition & Dietetics
Yu Qi Lee, Eugenie R. Lumbers, Tracy L. Schumacher, Clare E. Collins, Kym M. Rae, Kirsty G. Pringle
Summary: Suboptimal nutrition during pregnancy is recognized as a significant modifiable factor in the development of chronic diseases in offspring. The study found that dietary intake of pregnant Indigenous Australian women did not meet national guidelines and that maternal nutrition during pregnancy can impact fetal growth but not fetal kidney growth. Urgent strategies are needed to support and optimize nutrient intake in Indigenous pregnant women.
Article
Biology
Suhas Sureshchandra, Brianna M. Doratt, Norma Mendza, Oleg Varlamov, Monica Rincon, Nicole E. Marshall, Ilhem Messaoudi
Summary: Maternal pre-pregnancy obesity is linked to unfavorable outcomes in both mother and offspring, including increased susceptibility and severity of neonatal infections. This study reveals that pregravid obesity disrupts umbilical cord blood monocyte responses to bacterial and viral pathogens. It demonstrates that interferon-stimulated gene expression and inflammatory responses to respiratory syncytial virus and E. coli are significantly dampened. Additionally, it suggests that maternal obesity alters metabolic, signaling, and epigenetic profiles of fetal monocytes, leading to immune paralysis during late gestation and at birth.
Review
Nutrition & Dietetics
Sanjay Basak, Ranjit K. Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy
Summary: Obesity in pregnancy has various effects on fetal neurodevelopment, such as disturbing the transport of essential long-chain PUFAs for brain development and altering the maternal gut microbiota, which further affects fetal brain development.
Review
Nutrition & Dietetics
Alice Bosco, Deborah Dessi, Caterina Zanza, Roberta Pintus, Vassilios Fanos
Summary: Pregnancy is associated with mild inflammatory activity, which can increase with obesity, leading to persistent inflammation. Omega-3 fatty acids may play a crucial role in producing resolvins to mitigate the inflammatory state during pregnancy and improve maternal and neonatal health.
Article
Nutrition & Dietetics
Sarah Louise Killeen, Catherine M. Phillips, Anna Delahunt, Cara A. Yelverton, Nitin Shivappa, James R. Hebert, Maria A. Kennelly, Martina Cronin, John Mehegan, Fionnuala M. McAuliffe
Summary: The study found that an antenatal low-glycaemic index diet and physical activity intervention can reduce the inflammatory potential of diets. However, there was no association between early pregnancy E-DIITM and maternal and child outcomes, highlighting the importance of further exploring sex differences in future research.
Review
Nutrition & Dietetics
Imene Bennour, Nicole Haroun, Flavie Sicard, Lourdes Mounien, Jean-Francois Landrier
Summary: Observational studies show an inverse relationship between vitamin D concentration and obesity, but interventional and genetic studies have not provided clear conclusions. Evidence suggests that vitamin D supplementation may prevent obesity, and maternal vitamin D deficiency could impact the metabolic trajectory of offspring.
Review
Nutrition & Dietetics
Leonardo M. de Souza Mesquita, Lais Mennitti, Veridiana V. de Rosso, Luciana P. Pisani
Summary: The study provides an overview of the role of vitamin A and its pro-vitamin carotenoids during pregnancy and lactation, discussing their importance in offspring nutrition, metabolism, and biological effects. The review emphasizes the physiological role of these molecules in obesity prevention, and comprehensively summarizes their potential impact on nutritional status during pregnancy and lactation.
Article
Biochemistry & Molecular Biology
Susana P. Pereira, Mariana S. Diniz, Ludgero C. Tavares, Teresa Cunha-Oliveira, Cun Li, Laura A. Cox, Mark J. Nijland, Peter W. Nathanielsz, Paulo J. Oliveira
Summary: This study investigates the detectability of in utero fetal cardiac mitochondrial programming in early-stage IUGR pregnancy using a nonhuman primate model. The results show that early fetal responses to IUGR can be detected and that in utero cardiac mitochondrial adaptations are already present at this early stage. These adaptations affect the expression of oxidative phosphorylation subunits and may play a role in offspring's mitochondrial dysfunction and increased predisposition to cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Fernanda Priviero
Summary: Cardiovascular diseases (CVD) are the leading cause of death in the United States, with hypertension as a major risk factor. Genetic and modifiable factors both play a role in hypertension, with stress, sleep deprivation, obesity, and sedentarism contributing to epigenetic modifications that lead to hypertension. On the other hand, physical exercise and healthier habits can induce beneficial epigenetic changes and help prevent the inheritance of hypertension. Adverse environments during pregnancy and early life also increase the risk of hypertension and CVD, while healthier habits during this period can improve cardiovascular health in future generations by countering fetal programming.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Sally A. Eaton, Navind Jayasooriah, Michael E. Buckland, David I. K. Martin, Jennifer E. Cropley, Catherine M. Suter
Article
Endocrinology & Metabolism
Jennifer E. Cropley, Sally A. Eaton, Alastair Aiken, Paul E. Young, Eleni Giannoulatou, Joshua W. K. Ho, Michael E. Buckland, Simon P. Keam, Gyorgy Hutvagner, David T. Humphreys, Katherine G. Langley, Darren C. Henstridge, David I. K. Martin, Mark A. Febbraio, Catherine M. Suter
MOLECULAR METABOLISM
(2016)
Article
Endocrinology & Metabolism
S. A. Eaton, A. J. Aiken, P. E. Young, J. W. K. Ho, J. E. Cropley, C. M. Suter
INTERNATIONAL JOURNAL OF OBESITY
(2018)
Review
Endocrinology & Metabolism
Suzy S. J. Hur, Jennifer E. Cropley, Catherine M. Suter
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2017)
Article
Multidisciplinary Sciences
Saeideh Ebrahimkhani, Fatemeh Vafaee, Paul E. Young, Suzy S. J. Hur, Simon Hawke, Emma Devenney, Heidi Beadnall, Michael H. Barnett, Catherine M. Suter, Michael E. Buckland
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Clare L. van Eyk, Saumya E. Samaraweera, Andrew Scott, Dani L. Webber, David P. Harvey, Olivia Mecinger, Louise O'Keefe, Jennifer E. Cropley, Paul Young, Joshua Ho, Catherine Suter, Robert Richards
HUMAN MOLECULAR GENETICS
(2019)
Article
Biotechnology & Applied Microbiology
Helen McCormick, Paul E. Young, Suzy S. J. Hur, Keith Booher, Hunter Chung, Jennifer E. Cropley, Eleni Giannoulatou, Catherine M. Suter
Article
Cell Biology
L. M. Bourke, G. del Monte-Nieto, J. E. Outhwaite, V. Bharti, P. M. Pollock, D. G. Simmons, A. Adam, S. S. J. Hur, G. J. Maghzal, E. Whitelaw, R. Stocker, C. M. Suter, R. P. Harvey, S. K. Harten