Stability of the Retinoid X Receptor-α Homodimer in the Presence and Absence of Rexinoid and Coactivator Peptide

A revisited version of the apo structure of the ligand-binding domain of the human nuclear receptor retinoic X receptor α

(2019) Jérôme Eberhardt et al.   Acta Crystallographica Section F-Structural Biology Communications

A Randomized, Placebo-Controlled, Double-Blind, Dose Escalation, Single Dose and Steady State Pharmacokinetics Study of 9cUAB30 in Healthy Volunteers

(2019) Jill M Kolesar et al.   Cancer Prevention Research

The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis

(2018) Chu-Fang Chou et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

UAB30, a novel RXR agonist, decreases tumorigenesis and leptomeningeal disease in group 3 medulloblastoma patient-derived xenografts

(2018) Evan F. Garner et al.   JOURNAL OF NEURO-ONCOLOGY

The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission

(2017) Vikas Chandra et al.   Nature Communications

A comparison of biophysical characterization techniques in predicting monoclonal antibody stability

(2016) Geetha Thiagarajan et al.   mAbs

Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers

(2015) Venkatram R. Atigadda et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers

(2015) Douglas J. Kojetin et al.   Nature Communications

Methyl Substitution of a Rexinoid Agonist Improves Potency and Reveals Site of Lipid Toxicity

(2014) Venkatram R. Atigadda et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA

(2014) Xiaohua Lou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention

(2013) Anil Desphande et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Defining the Communication between Agonist and Coactivator Binding in the Retinoid X Receptor α Ligand Binding Domain

(2013) LeeAnn J. Boerma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The retinoid X receptors and their ligands

(2011) Marcia I. Dawson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Structure Basis of Bigelovin as a Selective RXR Agonist with a Distinct Binding Mode

(2011) Haitao Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure, Energetics, and Dynamics of Binding Coactivator Peptide to the Human Retinoid X Receptor α Ligand Binding Domain Complex with 9-cis-Retinoic Acid

(2010) Gang Xia et al.   BIOCHEMISTRY

Differential scanning calorimetry and fluorescence study of lactoperoxidase as a function of guanidinium–HCl, urea, and pH

(2010) Bogumil Zelent et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Pilot, First-in-Human, Pharmacokinetic Study of 9cUAB30 in Healthy Volunteers

(2010) J. M. Kolesar et al.   Cancer Prevention Research

Conformational Study of Red Kidney Bean (Phaseolus vulgaris L.) Protein Isolate (KPI) by Tryptophan Fluorescence and Differential Scanning Calorimetry

(2010) Shou-Wei Yin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide-binding domain 1

(2010) Irina Protasevich et al.   PROTEIN SCIENCE

Hydrogen/Deuterium Exchange Reveals Distinct Agonist/Partial Agonist Receptor Dynamics within Vitamin D Receptor/Retinoid X Receptor Heterodimer

(2010) Jun Zhang et al.   STRUCTURE

Silicon Analogues of the RXR-Selective Retinoid Agonist SR11237 (BMS649): Chemistry and Biology

(2009) W. Peter Lippert et al.   ChemMedChem

Stability of two β-tropomyosin isoforms: effects of mutation Arg91Gly

(2009) Ilya Nevzorov et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Equilibrium unfolding of the retinoid X receptor ligand binding domain and characterization of an unfolding intermediate

(2008) Mark E. Harder et al.   BIOPHYSICAL CHEMISTRY

A rapid, sensitive and economical assessment of monoclonal antibody conformational stability by intrinsic tryptophan fluorescence spectroscopy

(2008) Patrick Garidel et al.   Biotechnology Journal

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

(2008) Vikas Chandra et al.   NATURE