Covalent Stabilization of Antibody Recruitment Enhances Immune Recognition of Cancer Targets

Covalent Immune Recruiters (CIRs): Tools To Gain Chemical Control Over Immune Recognition.

(2020) Benjamin Lake et al.   ACS Chemical Biology

Unifying principles of bifunctional, proximity-inducing small molecules

(2020) Christopher J. Gerry et al.   Nature Chemical Biology

Lysosome-targeting chimaeras for degradation of extracellular proteins

(2020) Steven M. Banik et al.   NATURE

Fc‐binding antibody‐recruiting molecules targeting prostate‐specific membrane antigen: defucosylation of antibody for efficacy improvement

(2020) Koichi Sasaki et al.   CHEMBIOCHEM

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

(2019) Carl C. Ward et al.   ACS Chemical Biology

Efficient Innate Immune Killing of Cancer Cells Triggered by Cell Surface Anchoring of Multivalent Antibody-Recruiting Polymers

(2019) Annemiek Uvyn et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

(2019) Xiaoyu Zhang et al.   Nature Chemical Biology

Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity

(2018) Brett Schrand et al.   Nature Communications

Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density

(2018) Clifford M. Csizmar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Drifts in ADCC-related quality attributes of Herceptin®: Impact on development of a trastuzumab biosimilar

(2017) Seokkyun Kim et al.   mAbs

A Novel System for the Quantification of the ADCC Activity of Therapeutic Antibodies

(2017) Christophe Lallemand et al.   Journal of Immunology Research

Re-engineering the Immune Response to Metastatic Cancer: Antibody-Recruiting Small Molecules Targeting the Urokinase Receptor

(2016) Anthony F. Rullo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small-molecule PSMA ligands. Current state, SAR and perspectives

(2016) Alexey E. Machulkin et al.   JOURNAL OF DRUG TARGETING

Preparation and Evaluation of Radiolabeled Antibody Recruiting Small Molecules That Target Prostate-Specific Membrane Antigen for Combined Radiotherapy and Immunotherapy

(2016) Afaf R. Genady et al.   JOURNAL OF MEDICINAL CHEMISTRY

Folate-Hapten–Mediated Immunotherapy Synergizes with Vascular Endothelial Growth Factor Receptor Inhibitors in Treating Murine Models of Cancer

(2016) N. Achini Bandara et al.   MOLECULAR CANCER THERAPEUTICS

Molecular Mechanism and Energy Basis of Conformational Diversity of Antibody SPE7 Revealed by Molecular Dynamics Simulation and Principal Component Analysis

(2016) Jianzhong Chen et al.   Scientific Reports

Rapid Determination of the Specificity Constant of Irreversible Inhibitors (kinact/KI) by Means of an Endpoint Competition Assay

(2015) Ikuo Miyahisa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhamnose Glycoconjugates for the Recruitment of Endogenous Anti-Carbohydrate Antibodies to Tumor Cells

(2014) Rachael T. C. Sheridan et al.   CHEMBIOCHEM

LDAI-Based Chemical Labeling of Intact Membrane Proteins and Its Pulse-Chase Analysis under Live Cell Conditions

(2014) Takayuki Miki et al.   CHEMISTRY & BIOLOGY

Exploring Binding and Effector Functions of Natural Human Antibodies Using Synthetic Immunomodulators

(2013) Charles E. Jakobsche et al.   ACS Chemical Biology

Conformational Selection and Induced Fit in Specific Antibody and Antigen Recognition: SPE7 as a Case Study

(2013) Wei Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A Comprehensive Mathematical Model for Three-Body Binding Equilibria

(2013) Eugene F. Douglass et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Chemically Induced Vaccine Strategy for Prostate Cancer

(2011) Anna Dubrovska et al.   ACS Chemical Biology

Using Covalent Dimers of Human Carbonic Anhydrase II To Model Bivalency in Immunoglobulins

(2011) Eric T. Mack et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dependence of Avidity on Linker Length for a Bivalent Ligand–Bivalent Receptor Model System

(2011) Eric T. Mack et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Binding Affinity and Kinetic Analysis of Targeted Small Molecule-Modified Nanoparticles

(2009) Carlos Tassa et al.   BIOCONJUGATE CHEMISTRY

An Antibody-Recruiting Small Molecule That Targets HIV gp120

(2009) Christopher G. Parker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical Control over Immune Recognition: A Class of Antibody-Recruiting Small Molecules That Target Prostate Cancer

(2009) Ryan P. Murelli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY