TRIM21 drives intervertebral disc degeneration induced by oxidative stress via mediating HIF-1α degradation

The mitochondria‐targeted anti‐oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance

(2020) Liang Kang et al.   CELL PROLIFERATION

p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence

(2019) Emanuel J. Novais et al.   MATRIX BIOLOGY

MLN4924 Exerts a Neuroprotective Effect against Oxidative Stress via Sirt1 in Spinal Cord Ischemia-Reperfusion Injury

(2019) Sifei Yu et al.   Oxidative Medicine and Cellular Longevity

TRIM21—From Intracellular Immunity to Therapy

(2019) Stian Foss et al.   Frontiers in Immunology

Vhl deficiency in osteocytes produces high bone mass and hematopoietic defects

(2018) Gabriela G. Loots et al.   BONE

Acute and rapid degradation of endogenous proteins by Trim-Away

(2018) Dean Clift et al.   Nature Protocols

CD24 identifies nucleus pulposus progenitors/notochordal cells for disc regeneration

(2018) Zhuochao Liu et al.   Journal of Biological Engineering

Tripartite motif-containing (TRIM) 21 negatively regulates intestinal mucosal inflammation through inhibiting T H 1/T H 17 cell differentiation in patients with inflammatory bowel diseases

(2017) Guangxi Zhou et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Osteoblast Hypoxia-Inducible Factor-1α Pathway Activation Restrains Osteoclastogenesis via the Interleukin-33-MicroRNA-34a-Notch1 Pathway

(2017) Hui Kang et al.   Frontiers in Immunology

SHH-Dependent Knockout of HIF-1 Alpha Accelerates the Degenerative Process in Mouse Intervertebral Disc

(2017) W-J. Wu et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis

(2016) Ji-An Pan et al.   MOLECULAR CELL

Oxidative stress participates in age-related changes in rat lumbar intervertebral discs

(2014) Gang Hou et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

The internal mechanical functioning of intervertebral discs and articular cartilage, and its relevance to matrix biology

(2009) Michael A. Adams et al.   MATRIX BIOLOGY