Review
Nutrition & Dietetics
Mariano Brasal-Prieto, Laura Fernandez-Prades, Hala Dakhaoui, Francisco Sobrino, Soledad Lopez-Enriquez, Francisca Palomares
Summary: Food allergy is an adverse immunological reaction to specific food, with varying degrees of symptoms. Its prevalence has significantly increased, especially in developed countries. Approximately 2 to 10% of the global population is affected, with a higher rate in children. Diagnosis is complex, requiring multiple tests, and treatment involves avoiding allergenic foods and managing symptoms.
Review
Immunology
Julie M. Garcia, Cassandra E. Burnett, Kole T. Roybal
Summary: Synthetic biology tools, such as chimeric antigen receptors (CARs), have shown promise in targeting and improving immune cell responses to tumors, particularly in curing blood cancers. However, there are challenges in designing and translating these complex cell therapies for patients with immune refractory solid tumors. This article focuses on principles for engineering future cell therapies to increase clinical impact and provides an overview of the current state of synbio cell therapy design for cancer.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Goran Micevic, Andrew Daniels, Karine Flem-Karlsen, Koonam Park, Ronan Talty, Meaghan McGeary, Haris Mirza, Holly N. Blackburn, Esen Sefik, Julie F. Cheung, Noah I. Hornick, Lilach Aizenbud, Nikhil S. Joshi, Harriet Kluger, Akiko Iwasaki, Marcus W. Bosenberg, Richard A. Flavell
Summary: This study identifies a specific immune cell population with high IL-7R expression that plays a critical role in antitumor memory and can be enhanced through epigenetics to generate powerful antitumor immune responses. These findings have significant implications for preventing melanoma recurrence and developing new treatment options.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Fisheries
Isabela M. Di Chiacchio, Isadora M. Paiva, Danilo J. M. de Abreu, Elisangela E. N. Carvalho, Pedro J. Martinez, Stephan M. Carvalho, Victoriano Mulero, Luis David S. Murgas
Summary: The study evaluated the effects of bee pollen on zebrafish diet, showing that while bee pollen supplementation did not improve egg production and embryo viability, it did enhance offspring immunity and increase survival rate.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Review
Immunology
S. Alice Long, Jane H. Buckner
Summary: This review examines the current understanding of the etiology of Type 1 diabetes (T1D), focusing on the role of immune cells in the progression of the disease. It also highlights how this knowledge is driving the development of immunotherapies for the prevention and treatment of T1D.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Oncology
Marie Tourret, Nana Talvard-Balland, Marion Lambert, Ghada Ben Youssef, Mathieu F. Chevalier, Armelle Bohineust, Thomas Yvorra, Florence Morin, Saba Azarnoush, Olivier Lantz, Jean-Hugues Dalle, Sophie Caillat-Zucman
Summary: MAIT cells are semi-invariant T cells that recognize microbial antigens presented by MR1. They are predominantly found in the liver and barrier tissues, and are potent effectors of antimicrobial defense. Although they have potential therapeutic applications, it remains to be demonstrated whether they lack alloreactive potential.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Lavanya Sivapalan, Joseph C. Murray, Jenna VanLiere Canzoniero, Blair Landon, Jennifer Jackson, Susan Scott, Vincent Lam, Benjamin P. Levy, Mark Sausen, Valsamo Anagnostou
Summary: Circulating cell-free tumor DNA (ctDNA) can act as a real-time biomarker for tumor burden and provide valuable insights into the molecular changes of cancers during immunotherapy. While liquid biopsies offer quick and accurate evaluation of tumor dynamics, the complexity of immune responses cannot be fully captured by single-feature ctDNA analyses. Integrative studies modeling both the tumor and immune compartment are needed to understand tumor clearance kinetics and immune responses.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Immunology
Enitome E. Bafor, Julio C. Valencia, Howard A. Young
Summary: The immune regulation of female reproductive function plays a crucial role in fertility, disruptions in immune tolerance can lead to autoimmune subfertility or infertility. Double negative T regulatory cells (DNTregs) are emerging as effector cells capable of mediating immune tolerance in the female reproductive system, potentially providing a paradigm shift from the known roles of conventional regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Ashleigh R. Poh, Matthias Ernst
Summary: Macrophages play a crucial role in the pancreatic tumor microenvironment and are associated with poor patient survival. Pre-clinical studies have shown the diverse contributions of macrophages in PDAC development, however, the effectiveness of macrophage-targeting therapies in clinical trials is inconsistent.
Article
Oncology
[Anonymous]
Summary: Tumor immunology and cancer immunotherapy is a rapidly evolving field that has seen the implementation of various immunotherapies across different tumor types in the past decade. Novel strategies to overcome resistance and address the tumor microenvironment are currently the focus of research in this area. The Spanish Group for Cancer Immuno-Biotherapies (GeTICA) recently organized the IX Forum on Translational Immunology and Cancer Immunotherapy (FITCancer 9) in Madrid, which is the largest meeting dedicated to cancer immunotherapy and brings together clinicians, researchers, and experts in the field. This article presents abstracts from GeTICA members submitted to the forum.
Review
Immunology
Ningyue Sun, Yangzi Tian, Yuhan Chen, Weinan Guo, Chunying Li
Summary: Melanoma is a lethal type of skin cancer that is characterized by disordered metabolism. Metabolic rewiring in melanoma not only affects tumor cell behaviors but also interferes with antitumor immunity by influencing the functions of surrounding immune cells. This review summarizes the epidemiology, clinical characteristics, and treatment proceedings of melanoma, as well as the roles of immune cells and metabolic rewiring in tumor immunology.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biodiversity Conservation
Aimee J. Silla, Natalie E. Calatayud, Vance L. Trudeau, Steven Cooke
Summary: Captive breeding and reintroduction programs for threatened amphibian species face challenges in inducing reproductive behaviors and achieving high fertilization rates, requiring a combination of hormone therapies and environmental manipulation. Species-specific methods for handling, hormone administration, and environmental factors are crucial. Further research is needed to develop hormone therapies for a wider range of species to enhance global conservation efforts.
CONSERVATION PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Joel G. Rurik, Haig Aghajanian, Jonathan A. Epstein
Summary: Cardiac injury remains a major cause of morbidity and mortality worldwide, with a lack of understanding on why the heart fails to fully recover function after acute injury and why progressive heart failure frequently ensues. Recent studies have brought to light the significant contributions of the immune system to normal cardiac function and response to injury, offering promise for new treatment avenues for cardiac disease through immune modifying therapies.
CIRCULATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Suprava Das, Banendu Sunder Dash, Thejas P. Premji, Jyh-Ping Chen
Summary: This review discusses the mechanisms, benefits, and limitations of various immunotherapeutic approaches for glioblastoma (GBM) treatment, including immune checkpoint inhibitors, chimeric antigen receptors T cells, natural killer cells, vaccines, and combination therapy. It emphasizes the importance of immunotherapy in overcoming the current treatment limitations and improving survival rates in GBM patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Chantal Saberian, Noha Abdel-Wahab, Ala Abudayyeh, Hind Rafei, Jacinth Joseph, Gabriela Rondon, Laura Whited, Stephen Gruschkus, Faisal Fa'ak, May Daher, Cristina Knape, Houssein Safa, Mahran Shoukier, Maria E. Suarez-Almazor, Megan Marcotulli, Kaysia Ludford, Alison M. Gulbis, Marina Konopleva, Maro Ohanian, Farhad Ravandi, Guillermo Garcia-Manero, Betul Oran, Uday R. Popat, Rotesh Mehta, Amin M. Alousi, Naval Daver, Richard Champlin, Adi Diab, Gheath Al-Atrash
Summary: This study analyzed the association between GVHD prophylaxis and the frequency of GVHD in patients who received immune checkpoint inhibitors (ICIs) after allogeneic hematopoietic stem cell transplantation. The results indicated that post-transplantation cyclophosphamide (PTCy) was associated with a significantly reduced risk of acute GVHD in this group of patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)