Review
Medicine, General & Internal
Mengting Ding, Jiaxing Lin, Caipeng Qin, Ping Wei, Jiahe Tian, Tianxin Lin, Tao Xu
Summary: This review discusses the innovative applications of synthetic biology in the clinical diagnosis and treatment of bladder cancer, including the utilization of genetic elements to regulate gene expression, the design of gene circuits to distinguish cancer cells from normal cells, genetically modified T cells for targeted attacks, and synthetic nanomaterials for detecting and killing BC cells.
CHINESE MEDICAL JOURNAL
(2022)
Article
Pharmacology & Pharmacy
YangHao Fu, TianDuo Wang, John A. Ronald
Summary: Cellular immunotherapy has greatly improved cancer treatment, but there are still challenges in understanding patient-specific responses and designing effective therapies. This study developed a synthetic Notch receptor system and a simple blood test to monitor immune-cancer cell interactions in tumors. The system showed promising results in detecting antigen-dependent immune responses and could be a useful tool for improving cell-based immunotherapies.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
[Anonymous]
Summary: Tumor immunology and cancer immunotherapy is a rapidly evolving field that has seen the implementation of various immunotherapies across different tumor types in the past decade. Novel strategies to overcome resistance and address the tumor microenvironment are currently the focus of research in this area. The Spanish Group for Cancer Immuno-Biotherapies (GeTICA) recently organized the IX Forum on Translational Immunology and Cancer Immunotherapy (FITCancer 9) in Madrid, which is the largest meeting dedicated to cancer immunotherapy and brings together clinicians, researchers, and experts in the field. This article presents abstracts from GeTICA members submitted to the forum.
Article
Oncology
Jonathan J. Park, Adan Codina, Lupeng Ye, Stanley Lam, Jianjian Guo, Paul Clark, Xiaoyu Zhou, Lei Peng, Sidi Chen
Summary: Immunotherapy has revolutionized cancer treatments, but resistance remains a major challenge. This study investigates the genetic interactions between significantly mutated tumor suppressors and immune resistance genes in cancer cells' response to T cell killing. The findings provide insights into potential strategies for targeting clinically relevant cancer mutations using existing agents. The study also presents a technology platform and a double knockout library for studying genetic interactions between cancer mutations and immune resistance pathways.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Immunology
Daniel Hoces, Jesus Miguens Blanco, Rogelio A. Hernandez-Lopez
Summary: A synthetic circuit involves assembling genetic elements, biomolecules, or cells to create a defined function. In cancer therapeutics, engineering T cells with circuits has the potential to overcome current challenges by allowing specific targeting and killing of cancer cells.
IMMUNOLOGICAL REVIEWS
(2023)
Review
Immunology
Zihan Deng, Lisen Lu, Binghui Li, Xiujuan Shi, Honglin Jin, Weidong Hu
Summary: Inflammation is a critical feature in all stages of tumor development. Inflammasomes, as an important component of the inflammatory response and innate immune system, regulate infiltrating immune cell activity by signaling the secretion of different cytokines and chemokines. The expression patterns of inflammasomes vary across tumor types and stages, and understanding their specific effects is crucial for developing inflammasome-targeting drugs.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Oncology
Krishneel Prasad, Ryan S. Cross, Misty R. Jenkins
Summary: Synthetic biology has allowed for rewiring natural cellular responses to treat disease, as exemplified by CAR T cells as immunotherapy for cancer. Current research focuses on using noncanonical signaling pathways and synthetic gene circuitry to enhance the antitumor properties of engineered T cells. Two recent studies explore how these new technologies can achieve this goal, one using machine learning to predict CAR T cell phenotype and the other engineering controllable transcriptional regulators using synthetic zinc fingers. These studies expand the possibilities for future gene circuits and demonstrate how cellular therapy can respond to various environmental cues.
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
Ying Jing, Xue Chen, Kunyan Li, Yaoming Liu, Zhao Zhang, Yiqing Chen, Yuan Liu, Yushu Wang, Steven H. Lin, Lixia Diao, Jing Wang, Yanyan Lou, Douglas B. Johnson, Xiang Chen, Hong Liu, Leng Han
Summary: This study comprehensively demonstrates the associations between antibiotics and immune-related adverse events (irAEs) during anti-PD-1/PD-L1 therapy across a wide spectrum of cancers by analyzing multisource data. It suggests that the use of antibiotics in patients with cancer may potentially increase the risk of irAEs.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Kassidy M. Jungles, Erin A. Holcomb, Ashley N. Pearson, Kalli R. Jungles, Caroline R. Bishop, Lori J. Pierce, Michael D. Green, Corey W. Speers
Summary: Breast cancer is the most common non-skin cancer in females, and the immune system plays a crucial role in its treatment. Modulating the immune response through immunotherapy and combining it with radiotherapy may have synergistic effects. This review discusses the mechanisms and current clinical trials of combined approaches for breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Guilhem Lalle, Julie Twardowski, Yenkel Grinberg-Bleyer
Summary: NF-kappa B plays a crucial role in immune responses to cancer and could be targeted by novel immunotherapies.
Article
Multidisciplinary Sciences
Goran Micevic, Andrew Daniels, Karine Flem-Karlsen, Koonam Park, Ronan Talty, Meaghan McGeary, Haris Mirza, Holly N. Blackburn, Esen Sefik, Julie F. Cheung, Noah I. Hornick, Lilach Aizenbud, Nikhil S. Joshi, Harriet Kluger, Akiko Iwasaki, Marcus W. Bosenberg, Richard A. Flavell
Summary: This study identifies a specific immune cell population with high IL-7R expression that plays a critical role in antitumor memory and can be enhanced through epigenetics to generate powerful antitumor immune responses. These findings have significant implications for preventing melanoma recurrence and developing new treatment options.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Oncology
Youhuai Li, Mina Wang, Xueqiang Peng, Yingying Yang, Qishuang Chen, Jiaxing Liu, Qing She, Jichao Tan, Chuyuan Lou, Zehuan Liao, Xuexin Li
Summary: Messenger ribonucleic acid (mRNA) vaccines are a promising therapy for infectious diseases and cancer, particularly in the case of SARS-CoV2. Compared to conventional cancer vaccines, mRNA vaccines have advantages such as efficient immune response production, low side effects, and lower acquisition cost. This review discusses the development of cancer vaccines, mRNA cancer vaccines, their potential biological mechanisms, recent progress in tumor treatments, and future challenges and directions in the field.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Immunology
Anne Mette Askehoj Romer, Marie-Louise Thorseth, Daniel Hargbol Madsen
Summary: During tumor growth, the extracellular matrix undergoes remodeling, with a tumor-specific ECM of higher collagen density being associated with poor prognosis in cancer. Recent studies suggest that collagen can influence the function and phenotype of tumor-infiltrating immune cells, potentially affecting cancer progression and immunotherapy efficacy. Knowledge of collagen's immune modulatory functions may help improve current cancer therapies and develop new treatments.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Joseph Sia, Paul J. Neeson, Nicole M. Haynes
Summary: Although limited to a subset of patients, modern cancer immunotherapy has revolutionized the field of oncology. Radiation therapy is increasingly viewed as a unique partner for immunotherapy, as it can modulate the tumor immune microenvironment and reinvigorate immune responses against cancer.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Peng Deng, Zining Wang, Jinghong Chen, Shini Liu, Xiaosai Yao, Shaoyan Liu, Lizhen Liu, Zhaoliang Yu, Yulin Huang, Zhongtang Xiong, Rong Xiao, Jiuping Gao, Weiting Liang, Jieping Chen, Hui Liu, Jinghan Hong, Jason Yongsheng Chan, Peiyong Guan, Jianfeng Chen, Yali Wang, Jiaxin Yin, Jundong Li, Min Zheng, Chao Zhang, Penghui Zhou, Tiebang Kang, Bin Tean Teh, Qiang Yu, Zhixiang Zuo, Qingping Jiang, Jihong Liu, Ying Xiong, Xiaojun Xia, Jing Tan
Summary: In this study, RAD21 overexpression in ovarian cancer was found to be inversely correlated with IFN signature gene expression. RAD21 was shown to directly interact with YAP/TEAD4 and recruit NuRD complex to suppress IFN signaling. The study also demonstrated that RAD21 ablation enhanced the efficacy of anti-PD-1 treatment, suggesting RAD21 as a potential target and biomarker for precision immunotherapy in ovarian cancer.
JOURNAL OF CLINICAL INVESTIGATION
(2022)