Cap‐independent translation: A shared mechanism for lifespan extension by rapamycin, acarbose, and 17α‐estradiol

METTL3 expression is associated with glycolysis metabolism and sensitivity to glycolytic stress in hepatocellular carcinoma

(2020) Ye Lin et al.   Cancer Medicine

Acarbose improves health and lifespan in aging HET3 mice

(2019) David E. Harrison et al.   AGING CELL

Dynamic UTR Usage Regulates Alternative Translation to Modulate Gap Junction Formation during Stress and Aging

(2019) Michael J. Zeitz et al.   Cell Reports

METTL3/m6A/miRNA-873-5p Attenuated Oxidative Stress and Apoptosis in Colistin-Induced Kidney Injury by Modulating Keap1/Nrf2 Pathway

(2019) Jian Wang et al.   Frontiers in Pharmacology

Identification and Application of Gene Expression Signatures Associated with Lifespan Extension

(2019) Alexander Tyshkovskiy et al.   Cell Metabolism

Lifespan extension drug interventions affect adipose tissue inflammation in aging

(2019) Theresa Mau et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Cap-independent mRNA translation is upregulated in long-lived endocrine mutant mice

(2019) Ulas Ozkurede et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Signaling Pathways Involved in the Regulation of mRNA Translation

(2018) Philippe P. Roux et al.   MOLECULAR AND CELLULAR BIOLOGY

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

(2018) Junho Choe et al.   NATURE

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

A fly view on the roles and mechanisms of the m6A mRNA modification and its players

(2017) Tina Lence et al.   RNA Biology

mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice

(2016) Graham Dominick et al.   AGING CELL

Comparative idiosyncrasies in life extension by reduced mTOR signalling and its distinctiveness from dietary restriction

(2016) Michael Garratt et al.   AGING CELL

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

(2016) Randy Strong et al.   AGING CELL

More than just scanning: the importance of cap-independent mRNA translation initiation for cellular stress response and cancer

(2016) Rafaela Lacerda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

N 6-Methyladenosine (m6A) Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification

(2016) Ruifan Wu et al.   MOLECULAR BIOTECHNOLOGY

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells

(2016) Shuibin Lin et al.   MOLECULAR CELL

Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice

(2015) Emma L. Baar et al.   AGING CELL

Regulation of mTOR Activity in Snell Dwarf and GH Receptor Gene-Disrupted Mice

(2015) Graham Dominick et al.   ENDOCRINOLOGY

Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity

(2015) Shihyin Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamic m6A mRNA methylation directs translational control of heat shock response

(2015) Jun Zhou et al.   NATURE

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

(2013) David E. Harrison et al.   AGING CELL

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

Hyperglycemia Mediates a Shift From Cap-Dependent to Cap-Independent Translation Via a 4E-BP1-Dependent Mechanism

(2013) M. D. Dennis et al.   DIABETES

Rapamycin Extends Life and Health in C57BL/6 Mice

(2013) Yiqiang Zhang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

N6-methyl-adenosine (m6A) in RNA: An Old Modification with A Novel Epigenetic Function

(2012) Yamei Niu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Effects of Acarbose Treatment on Markers of Insulin Sensitivity and Systemic Inflammation

(2011) Natalia N. Rudovich et al.   Diabetes Technology & Therapeutics

The metabolic footprint of aging in mice

(2011) Riekelt H. Houtkooper et al.   Scientific Reports

PI3K-mTORC1 Attenuates Stress Response by Inhibiting Cap-independent Hsp70 Translation

(2010) Jun Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

EFFECTS OF CHRONIC ACARBOSE TREATMENT ON ADIPOCYTE INSULIN RESPONSIVENESS, SERUM LEVELS OF LEPTIN AND ADIPONECTIN AND HYPOTHALAMIC NPY EXPRESSION IN OBESE DIABETIC WISTAR RATS

(2007) Coralia Pérez et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY