Article
Chemistry, Multidisciplinary
Xianglian Li, Hui Liu, Ailing Yu, Dan Lin, Zhishu Bao, Yuqin Wang, Xingyi Li
Summary: The newly designed NapFFKKFKLKL/Dexp supramolecular hydrogel displayed controlled drug release behavior, good intraocular biocompatibility, and potent anti-inflammatory capacity, making it a promising drug carrier system for treating posterior disorders such as uveitis.
CHINESE CHEMICAL LETTERS
(2021)
Article
Engineering, Biomedical
Tong Li, Xian-Mao Lu, Ming-Rong Zhang, Kuan Hu, Zhou Li
Summary: Peptide-based self-assembly nanomaterials, with diverse structures and functionalities, play a significant role in bioapplications. This review provides an overview of the recent advances in peptide-based self-assembly nanostructures, focusing on the driving forces and assembly mechanisms. It also summarizes the synthesis, properties, and applications of functional peptide nanomaterials. The challenges and future prospects of peptide-based nanomaterials are discussed.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Ruo-Chen Guo, Xue-Hao Zhang, Peng-Sheng Fan, Ben-Li Song, Zhi-Xiang Li, Zhong-Yu Duan, Zeng-Ying Qiao, Hao Wang
Summary: A novel in vivo self-assembly strategy is developed to induce phase separation of cell membrane, improving the internalization of therapeutic peptides and enhancing drug delivery efficacy, particularly in cancer therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Biomaterials
Xiang Li, Huijun Zhang, Lingyan Liu, Chunyan Cao, Peng Wei, Xin Yi, Yifeng Zhou, Qingyang Lv, Dongfang Zhou, Tao Yi
Summary: This article introduces a new peptide-based hydrogelator Fmoc-FFRRVR, which is easier to form a hydrogel under mild conditions compared to the traditional Fmoc-FF, with a gelation time of only 2 seconds. Fmoc-FFRRVR self-assembles into organized arrays of beta-sheets in nanofibers, displaying elasticity, reversibility, and injectability, making it suitable for biomedical applications such as drug carriers.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Multidisciplinary
Zeynep Cimen, Sena Babadag, Sedat Odabas, Sevde Altuntas, Gokhan Demirel, Gokcen Birlik Demirel
Summary: Injectable, self-healable, and pH-responsive hybrid hydrogels offer a promising potential for controlled and long-term drug release in cancer treatment. The gelation time is short, with excellent injectability and self-healing capability, alongside outstanding gelation stability. The hybrid hydrogels also exhibit efficient pH-dependent drug release and excellent biocompatibility with support for cell proliferation.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Engineering, Biomedical
Ziv Azoulay, Polina Aibinder, Ayala Gancz, Jacob Moran-Gilad, Shiri Navon-Venezia, Hanna Rapaport
Summary: FKF, a tripeptide with potential antimicrobial activity, forms a pure peptide hydrogel phase made of natural amino acids. The hydrogel exhibits bactericidal activity against E. coli and P. aeruginosa, and reduces P. aeruginosa contamination in a rat skin lesion model.
ACTA BIOMATERIALIA
(2021)
Article
Biophysics
Chunqian Zhao, Hongyuan Chen, Fengshan Wang, Xinke Zhang
Summary: Amphiphilic self-assembling peptides are widely used in biomedical fields due to their good compatibility and potential for drug delivery. However, there are no defined rules for their design and development, and rational strategies are needed for research. These peptides have a variety of applications in drug delivery, including delivering hydrophobic drugs and vaccines.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Jun Zheng, Xianwen Song, Zhaoyu Yang, Chao Yin, Weikang Luo, Chunyang Yin, Yaqiong Ni, Yang Wang, Yi Zhang
Summary: Self-assembling hydrogels composed of therapeutic agents offer a promising approach for local drug delivery, with advantages such as biocompatibility, high drug-loading efficiency, low systemic toxicity, and sustained drug release behavior. The self-assembly technique provides better opportunities to improve the precision of pharmaceutical treatment and achieve superior treatment efficacy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Shu Hui Hiew, Jun Kit Wang, Kenrick Koh, Haibo Yang, Abbas Bacha, Junquan Lin, Yun Sheng Yip, Marcus Ivan Gerard Vos, Liyan Chen, Radoslaw M. Sobota, Nguan Soon Tan, Chor Yong Tay, Ali Miserez
Summary: The bioinspired octapeptide GV8 can self-assemble into biodegradable physical hydrogels, encapsulating macromolecular therapeutics and exhibiting controlled drug release. It shows promise for wound healing applications by maintaining growth factor activity and promoting epithelial cell migration. This versatile and safe carrier represents a promising biomaterial for regenerative medicine applications.
ACTA BIOMATERIALIA
(2021)
Review
Polymer Science
Qi Wang, Yanfei Qu, Ziyi Zhang, Hao Huang, Yufei Xu, Fengyun Shen, Lihua Wang, Lele Sun
Summary: Regulated drug delivery is an important area of research in medicine and healthcare. Injectable hydrogels, particularly DNA hydrogels, have gained significant attention for their biocompatibility and biodegradability in controlled drug release and immunotherapy. DNA hydrogel, a three-dimensional network formed by linking hydrophilic DNA strands, offers precise design of mechanical properties and functions through its editable sequence and hybridization reactions. Additionally, integration with other functional materials enriches the capabilities of DNA hydrogels. This review provides an overview of DNA hydrogel types, synthesis methods, and recent research progress in local drug delivery and immunotherapy, as well as discusses challenges and future directions.
Article
Chemistry, Multidisciplinary
Huilei Dong, Mingshui Wang, Shihui Fan, Chuanliu Wu, Chunhui Zhang, Xia Wu, Bin Xue, Yi Cao, Junjie Deng, Dan Yuan, Junfeng Shi
Summary: This study reports the folding of a thiol-rich peptide into an amphiphilic beta-hairpin conformation through the formation of two hetero-disulfide bonds, and its subsequent self-assembly into a hydrogel. It is the first case of using multiple disulfide bonds to control conformational change and self-assembly, providing a cell-compatible hydrogel material for potential biomedical applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Payel Dowari, Shalini Roy, Saurav Das, Sumit Chowdhuri, Ritvika Kushwaha, Basab K. Das, Anindita Ukil, Debapratim Das
Summary: A mannose-containing composite hydrogel was prepared by combining a self-aggregating short peptide and a mannose-containing non-aggregating peptide. The hydrogel showed stability, biodegradability, non-cytotoxicity, and efficient drug delivery to kill the parasite.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Applied
Huimin Chen, Tianrui Zhang, Yongqi Tian, Lijun You, Yan Huang, Shaoyun Wang
Summary: This study provides insights into the mechanism of peptide gelation, offering a way to control self-assembly behaviors and achieve a variety of nanostructures. The peptide assembly process involves five stages and is highly influenced by the charging status of terminal groups. Additionally, the successful loading of curcumin into different self-assembly nanostructures demonstrates high encapsulation efficiency and effective protection.
FOOD HYDROCOLLOIDS
(2022)
Article
Biotechnology & Applied Microbiology
Yang Wang, Xiao Li, Juzheng Yuan, Xudan Wang, Kaishan Tao, Jin Yan
Summary: In this study, an injectable hydrogel with hemostatic and bactericidal function based on Bionic Self-Assembling Peptide (BSAP) was developed. The hydrogel showed rapid formation of a network structure in vivo and exhibited excellent physicochemical properties. It effectively reduced blood clotting time and bleeding volume, and also reduced inflammatory responses by blocking bacterial infection and promoting wound healing. The results provide a strategy for developing a high-biosecurity hydrogel with hemostatic and antibacterial properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fang Wang, Kexin Huang, Ziqi Xu, Fengna Shi, Cheng Chen
Summary: In this study, two nanocomposite polysaccharide hydrogels were developed using a simple mixing method. The hydrogels exhibited improved tensile strength, fatigue resistance, and self-healing ability due to the presence of dynamic bonds. Additionally, the drug-loaded nanocomposite hydrogels showed sustained release and increased release under acidic conditions, making them promising candidates for drug delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Jie Zhan, Yuhan Wang, Shaodan Ma, Qin Qin, Ling Wang, Yanbin Cai, Zhimou Yang
Summary: Organelles are responsible for the storage and transport of substances in living systems. Researchers have developed a biomimetic delivery strategy inspired by natural cargo delivery by organelles, which can improve the efficiency of cancer therapy.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Keda Chen, Xiaoxin Wu, Qingjing Wang, Ying Wang, Haiyan Zhang, Shuai Zhao, Chaonan Li, Zhiwen Hu, Zhimou Yang, Lanjuan Li
Summary: Repeated waves of H7N9 influenza virus have caused severe influenza in humans since 2013, with a high mortality rate. To prevent possible pandemics, the development of highly effective vaccines against H7N9 is crucial. In this study, a simple method using a peptide hydrogel adjuvant was reported to prepare the H7N9 vaccine, which showed better preventive effects against H7N9 infection compared to traditional adjuvant vaccines. The study also revealed higher antibody responses and variations in cytokine expression as potential mechanisms for the increased protective effects of the hydrogel adjuvant vaccine.
CHINESE CHEMICAL LETTERS
(2023)
Article
Biotechnology & Applied Microbiology
Ke Jian, Chenghao Yang, Tingting Li, Xia Wu, Jun Shen, Jiaying Wei, Zhimou Yang, Dan Yuan, Mingyi Zhao, Junfeng Shi
Summary: Chronic wounds present a major challenge to the healthcare system. This study designed a PDGF-mimicking peptide that can promote angiogenesis and collagen deposition, showing promising therapeutic effects for wound healing.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Limin Xie, Yinghao Ding, Yuhan Wang, Xinxin Li, Zhimou Yang, Zhi-Wen Hu
Summary: This study reports a phosphorylation-dependent pre-organization approach to optimize the therapeutic outcomes of a self-assembling peptide targeting PD-L1. The presence of a phosphate group stabilizes the peptide in a preorganized state, resulting in enhanced binding affinity against PD-L1 and improved therapeutic performance.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yinghao Ding, Debin Zheng, Limin Xie, Xiangyang Zhang, Zhenghao Zhang, Ling Wang, Zhi-Wen Hu, Zhimou Yang
Summary: An enzyme-instructed peptide self-assembly (EISA) strategy is used to selectively modify cancer cell membranes, and different phosphorylation patterns in phosphopeptides targeting EGFR can impact their self-assembly abilities and binding affinity for EGFR. The phosphorylated peptide pY1 shows the highest capability for preorganization and the fastest dephosphorylation in the presence of alkaline phosphatase (ALP), making it the most effective at constructing stable peptide assemblies on cancer cell membranes. Additionally, peptide-protein and peptide-peptide co-assembly strategies are employed to apply antigens to cancer cell membranes, offering a potential technique for cancer immunotherapy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Engineering, Biomedical
Hongwei Wu, Yuna Shang, Wei Sun, Xinyi Ouyang, Wenyan Zhou, Jieji Lu, Shuhui Yang, Wei Wei, Xudong Yao, Xiaozhao Wang, Xianzhu Zhang, Yishan Chen, Qiulin He, Zhimou Yang, Hongwei Ouyang
Summary: This study developed a strategy to enhance integration of the gap region following mosaicplasty by applying BSN-GelMA hydrogel. The results showed that BSN-GelMA achieved seamless osteochondral healing in the gap region, with improved cartilage repair scores, glycosaminoglycan content, subchondral bone volume, and collagen II expression. This study provides a powerful approach to improve gap integration after autologous mosaicplasty and offers a promising bioactive material for cell-free tissue regeneration.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Weidong Wu, Shuaijun Jia, Hailiang Xu, Ziheng Gao, Zhiyuan Wang, Botao Lu, Yixiang Ai, Youjun Liu, Renfeng Liu, Tong Yang, Rongjin Luo, Chunping Hu, Lingbo Kong, Dageng Huang, Liang Yan, Zhimou Yang, Lei Zhu, Dingjun Hao
Summary: A strategy of using PDGF-MP hydrogel microspheres instead of bulk hydrogels can enhance the efficiency of PDGF-MP in activating its receptor, thus improving the therapeutic ability of neural stem cells (NSCs) in treating spinal cord injuries (SCI). In vitro experiments showed that PDGF-MP hydrogel microspheres maintained the proliferation and inhibited the apoptosis of NSCs in the presence of myelin extracts. In vivo experiments demonstrated that PDGF-MP hydrogel microspheres inhibited inflammatory cell infiltration and cell apoptosis, and promoted axonal regeneration, synapse formation, and angiogenesis in SCI rats.
Article
Chemistry, Physical
Limin Xie, Yinghao Ding, Xiangyang Zhang, Zhenghao Zhang, Sheng Zeng, Ling Wang, Zhimou Yang, Qian Liu, Zhi-Wen Hu
Summary: The researchers constructed a multifunctional drug-loaded peptide nanomedicine (Comp. 4) for ICD-based cancer therapy. Comp. 4 interferes with mitochondrial functions, targets the cell membrane and mitochondria, and forms peptide assemblies in the presence of ALP. Comp. 4 induces mitochondrial oxidative stress, provokes robust ICD responses, and successfully inhibits colon cancer growth by eliciting a systemic ICD-based antitumor immunity.
Article
Chemistry, Multidisciplinary
Yumiao Chen, Wei Li, Zhongqiu Wang, Yingying Yu, Jie Li, Yinghao Ding, Zhiwen Hu, Qian Liu, Zhimou Yang, Jie Gao
Summary: This study introduces a novel cancer immunotherapy tool, Supra-BiCE, that enhances the binding of immune cells to tumor cells by transforming nanoribbons into nanofibrils, leading to the accumulation and activation of immune cells within tumor regions.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xiangyang Zhang, Yinghao Ding, Zhenghao Zhang, Yiping Ma, Xuan Sun, Ling Wang, Zhimou Yang, Zhi-Wen Hu
Summary: Manipulating cancer cell death through precise control of reactive oxygen species (ROS) is a promising strategy for treating malignant tumors. However, generating active ROS with spatial precision and regulating their biological outcomes is challenging. In this study, we successfully generated short-lived and lipid-reactive hydroxyl radicals ((OH)-O-·) adjacent to cancer cell membranes, leading to lipid peroxidation and ferroptosis. By using a phosphorylated self-assembling precursor, we selectively produced membrane-bound nanofibers and enriched ferrocene moieties on cancer cell membranes, resulting in the conversion of tumoral H2O2 to active (OH)-O-· through Fenton-like reactions. Our strategy effectively prevented tumor progression with good cellular selectivity and acceptable biocompatibility through intratumoral administration.
Article
Chemistry, Multidisciplinary
Zhuhong Zhang, Shengjun Peng, Tengyan Xu, Jia Liu, Laien Zhao, Hui Xu, Wen Zhang, Yuanying Zhu, Zhimou Yang
Summary: In this study, a self-assembling peptide GFFYE was designed and synthesized to transform rhein, a hydrophobic compound, into a sustained-release therapeutic agent. Rhein-based nanofibers were constructed for the treatment of retinal ischemia-reperfusion (RIR) injury, and they showed significant improvement in oxidative stress and inflammation. Moreover, the nanofibers promoted the transition of macrophages from pro-inflammatory to anti-inflammatory type.
Article
Chemistry, Multidisciplinary
Zhongyan Wang, Yuna Shang, Hongjing Luo, Cuihong Yang, Zhimou Yang, Chunhua Ren, Jianfeng Liu
Summary: This study presents a novel strategy of achieving higher hierarchical structures through cooperative self-assembly of hydrophobic tripeptides with reverse sequences, showing a low-to-high hierarchical structure transformation. The cooperation between different sequences also allows different morphological transitions, promoting a more compact molecular arrangement by creating more hydrogen bond interactions and in-register π-π stacking in the anti-parallel β-sheet conformation. This work provides a handy approach for controlled hierarchical assembly and the development of various functional bionanomaterials.
Review
Chemistry, Multidisciplinary
Xiangyang Zhang, Junxia Wang, Ying Zhang, Zhimou Yang, Jie Gao, Zhen Gu
Summary: Living organisms fabricate biomacromolecules such as DNA, RNA, and proteins through self-assembly, and understanding this process has led to exploration in synthesizing biomaterials within living organisms. In recent decades, these in vivo synthesized biomaterials have been extensively applied in cell-fate manipulation, disease theranostics, bioanalysis, cellular surface engineering, and tissue regeneration.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Materials Science, Biomaterials
Yiming Zhang, Zhiwen Hu, Xinxin Li, Yinghao Ding, Zhenghao Zhang, Xiangyang Zhang, Wenting Zheng, Zhimou Yang
Summary: The amino acid sequence of the peptide determines the adjuvant potency of Gel-gffy. The position and number of aromatic amino acids play a crucial role in the immunostimulatory activity of Gel-gffy. These findings provide valuable insights into designing peptide hydrogels as vaccine adjuvants.
BIOMATERIALS SCIENCE
(2022)
Article
Materials Science, Biomaterials
Xinxin Li, Youzhi Wang, Yiming Zhang, Zhimou Yang, Jie Gao, Yang Shi
Summary: Enzyme-instructed self-assembly (EISA) strategy has important advantages in the preparation of supramolecular self-assembly materials for biomedical applications, facilitating the self-assembly and hydrogelation of hydrophobic and bioactive peptides. By designing phosphorylated precursors, supramolecular hydrogels can be formed through dephosphorylation by alkaline phosphatase (ALP). Furthermore, EISA can also occur on the surface of cells that overexpress ALP.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
