期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 19, 页码 22159-22168出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c02116
关键词
antibody-like polymeric nanoparticle; galectin-1; macrophage; tumor microenvironment; cancer immunotherapy
资金
- National Natural Science Foundation of China(China
- NSFC) [22077073, 22007051]
- National Key Research and Development Programs of China (China) [2018YFA0209700]
- Fundamental Research Funds for the Central Universities (China
- Nankai University) [ZB16008705]
The newly developed antibody-like polymeric nanoparticle (APN) has the potential to enhance antitumor T-cell responses by capturing and removing galectin-1 in tumor tissues. With recognition units and Tuftsin peptides, the APN can activate macrophage-mediated phagocytosis, improving therapeutic outcomes.
Antibodies have shown potential to deplete immunosuppressive factors in tumor tissues. However, intrinsic drawbacks, including time-consuming processes in preparation, high cost, and short half-life time, greatly restrict their applications. In this work, we report an antibody-like polymeric nanoparticle (APN) that is capable of specifically capturing and removing galectin-1 in tumor tissues, thereby enhancing the antitumor T-cell responses. The APN is composed of an albumin-polymer hybrid nanoparticle (core) and an acid-responsive PEG shell. The core of the APN contains multiple recognition units and Tuftsin peptides to capture target factors and activate macrophage-mediated phagocytosis, respectively. By employing galactose as recognition units, the APN facilitated the phagocytosis of galectin-1 in tumor tissues, thereby improving the antitumor responses of tumor-infiltrating T cells. Since the recognition units in the APN can be further replaced to capture and remove other peptides/proteins, the APN provides a feasible approach for the development of synthetic nanoformulations to regulate biological systems and treat diseases.
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