标题
Small-Molecule Tunnels in Metalloenzymes Viewed as Extensions of the Active Site
作者
关键词
-
出版物
ACCOUNTS OF CHEMICAL RESEARCH
Volume 54, Issue 9, Pages 2185-2195
出版商
American Chemical Society (ACS)
发表日期
2021-04-23
DOI
10.1021/acs.accounts.1c00058
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mechanism of Molecular Oxygen Diffusion in a Hypoxia-Sensing Prolyl Hydroxylase Using Multiscale Simulation
- (2020) Carmen Domene et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Different ways to transport ammonia in human and Mycobacterium tuberculosis NAD+ synthetases
- (2020) Watchalee Chuenchor et al. Nature Communications
- Structural Studies of the Methylosinus trichosporium OB3b Soluble Methane Monooxygenase Hydroxylase and Regulatory Component Complex Reveal a Transient Substrate Tunnel
- (2020) Jason C. Jones et al. BIOCHEMISTRY
- High-Resolution XFEL Structure of the Soluble Methane Monooxygenase Hydroxylase Complex with its Regulatory Component at Ambient Temperature in Two Oxidation States
- (2020) Vivek Srinivas et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Gas Sensing by Bacterial H-NOX Proteins: An MD Study
- (2020) Ahmed M. Rozza et al. MOLECULES
- Crystallographic Characterization of the Carbonylated A-cluster in Carbon Monoxide Dehydrogenase/acetyl-CoA Synthase
- (2020) Steven E. Cohen et al. ACS Catalysis
- Negative-Stain Electron Microscopy Reveals Dramatic Structural Rearrangements in Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase
- (2020) Steven E. Cohen et al. STRUCTURE
- Soluble Methane Monooxygenase
- (2019) Rahul Banerjee et al. Annual Review of Biochemistry
- Bacterial denitrifying nitric oxide reductases and aerobic respiratory terminal oxidases use similar delivery pathways for their molecular substrates
- (2018) Paween Mahinthichaichan et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Tracking the route of molecular oxygen in O2-tolerant membrane-bound [NiFe] hydrogenase
- (2018) Jacqueline Kalms et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Understanding Biological Hydrogen Transfer Through the Lens of Temperature Dependent Kinetic Isotope Effects
- (2018) Judith P. Klinman et al. ACCOUNTS OF CHEMICAL RESEARCH
- Computational investigation of O2 diffusion through an intra-molecular tunnel in AlkB; influence of polarization on O2 transport
- (2017) Hedieh Torabifard et al. Chemical Science
- Understanding the Molecular Mechanism of the Ala-versus-Gly Concept Controlling the Product Specificity in Reactions Catalyzed by Lipoxygenases: A Combined Molecular Dynamics and QM/MM Study of Coral 8R-Lipoxygenase
- (2017) Patricia Saura et al. ACS Catalysis
- O2 Activation by Non-Heme Iron Enzymes
- (2016) Edward I. Solomon et al. BIOCHEMISTRY
- All the O2 Consumed by Thermus thermophilus Cytochrome ba3 Is Delivered to the Active Site through a Long, Open Hydrophobic Tunnel with Entrances within the Lipid Bilayer
- (2016) Paween Mahinthichaichan et al. BIOCHEMISTRY
- Control of the Position of Oxygen Delivery in Soybean Lipoxygenase-1 by Amino Acid Side Chains within a Gas Migration Channel
- (2016) Lara Collazo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanism of O2 diffusion and reduction in FeFe hydrogenases
- (2016) Adam Kubas et al. Nature Chemistry
- Evolution of P450 Monooxygenases toward Formation of Transient Channels and Exclusion of Nonproductive Gases
- (2016) Maximilian C. C. J. C. Ebert et al. ACS Catalysis
- Substrate Pathways in the Nitrogenase MoFe Protein by Experimental Identification of Small Molecule Binding Sites
- (2015) Christine N. Morrison et al. BIOCHEMISTRY
- Structure of the key species in the enzymatic oxidation of methane to methanol
- (2015) Rahul Banerjee et al. NATURE
- Substrate Channel in Nitrogenase Revealed by a Molecular Dynamics Approach
- (2014) Dayle Smith et al. BIOCHEMISTRY
- Quantum Mechanical Basis for Kinetic Diameters of Small Gaseous Molecules
- (2014) Nada Mehio et al. JOURNAL OF PHYSICAL CHEMISTRY A
- Hydrogen Tunneling Links Protein Dynamics to Enzyme Catalysis
- (2013) Judith P. Klinman et al. Annual Review of Biochemistry
- Gates of Enzymes
- (2013) Artur Gora et al. CHEMICAL REVIEWS
- Uncovering a Dynamically Formed Substrate Access Tunnel in Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase
- (2013) Po-hung Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Control of substrate access to the active site in methane monooxygenase
- (2013) Seung Jae Lee et al. NATURE
- A molecular pathway for the egress of ammonia produced by nitrogenase
- (2013) Ian Dance Scientific Reports
- Mechanistic insight into the blocking of CO diffusion in [NiFe]-hydrogenase mutants through multiscale simulation
- (2012) P.-h. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dioxygen Activation in Soluble Methane Monooxygenase
- (2011) Christine E. Tinberg et al. ACCOUNTS OF CHEMICAL RESEARCH
- Analysis of Substrate Access to Active Sites in Bacterial Multicomponent Monooxygenase Hydroxylases: X-ray Crystal Structure of Xenon-Pressurized Phenol Hydroxylase fromPseudomonassp. OX1
- (2011) Michael S. McCormick et al. BIOCHEMISTRY
- Multiscale Simulation Reveals Multiple Pathways for H2and O2Transport in a [NiFe]-Hydrogenase
- (2011) Po-hung Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Tracking a defined route for O2 migration in a dioxygen-activating diiron enzyme
- (2011) W. J. Song et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain
- (2011) M. B. Winter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tight Coupling of Partial Reactions in the Acetyl-CoA Decarbonylase/Synthase (ACDS) Multienzyme Complex fromMethanosarcina thermophila
- (2010) Simonida Gencic et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Basis of Biological N2O Generation by Bacterial Nitric Oxide Reductase
- (2010) T. Hino et al. SCIENCE
- Structural Basis for Activation of Class Ib Ribonucleotide Reductase
- (2010) A. K. Boal et al. SCIENCE
- A substrate channel in the nitrogenase MoFe protein
- (2009) Brett M. Barney et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- A Combined Theoretical and Experimental Study of the Ammonia Tunnel in Carbamoyl Phosphate Synthetase
- (2009) Yubo Fan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Relating diffusion along the substrate tunnel and oxygen sensitivity in hydrogenase
- (2009) Pierre-Pol Liebgott et al. Nature Chemical Biology
- CD and MCD Studies of the Effects of Component B Variant Binding on the Biferrous Active Site of Methane Monooxygenase†
- (2008) Nataša Mitić et al. BIOCHEMISTRY
- Xenon in and at the End of the Tunnel of Bifunctional Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase†,‡
- (2008) Tzanko I. Doukov et al. BIOCHEMISTRY
- Versatility of biological non-heme Fe(II) centers in oxygen activation reactions
- (2008) Elena G Kovaleva et al. Nature Chemical Biology
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