Article
Fisheries
Xiangyang Yuan, Canli Wang, Wenbin Liu, Guangzhen Jiang, Yongjun Dai
Summary: The study found that 10g/kg and 30g/kg of YH increased the crude protein content in fish muscle and upregulated the expression levels of TOR pathway genes in muscle and hepatocytes.
AQUACULTURE NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Moon-Young Song, Da-Young Lee, Kyung-Soo Chun, Eun-Hee Kim
Summary: NRF2 and KEAP1 are crucial regulators of redox homeostasis, and their signaling pathway is associated with cancer cell proliferation and tumorigenesis. Modulating this pathway may serve as a novel therapeutic strategy for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ying Li, Yanping Ma, Le Hao, Jiangyao Ma, Zhiling Liang, Zhenxing Liu, Hao Ke, Yugu Li
Summary: A new cell line, CCB-J, derived from Jian carp brain tissue was established and found to be more sensitive and efficient in replicating KHV virus compared to other widely used cell lines. This cell line shows potential for use in viral pathogenesis and vaccine research.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Fisheries
Zonglu Wei, Yutong Zhuang, Xinting Liu, Danyang Zou, Kangsen Mai, Zhenzhu Sun, Chaoxia Ye
Summary: Leucine promotes protein deposition and glucose metabolism through the TOR signaling pathway in Pacific white shrimp. Appropriate dietary leucine supplementation improves protein synthesis and glucose utilization by maintaining the integrity of hepatopancreas. The leucine requirement of Litopenaeus vannamei is estimated to be 2.60%-2.67% of the diet (6.67%-6.88% of dietary protein) based on regression analysis.
Review
Genetics & Heredity
Jiaen Sun, Minglei Yang, Weidi Zhao, Fajiu Wang, Liangwei Yang, Chuntao Tan, Tianjun Hu, Huangkai Zhu, Guofang Zhao
Summary: Protein phosphorylation/dephosphorylation is an important regulatory mechanism for controlling cellular processes, and alterations in phosphorylation networks have major implications in diseases, including cancer. TOR signaling pathway and TIPRL play crucial roles in the cell cycle and their dysregulation may contribute to tumorigenesis. This review aims to provide comprehensive insights into the role of TIPRL in cancer development, as well as the TIPRL/PP2A axis and its epigenetic regulation.
FRONTIERS IN GENETICS
(2022)
Article
Fisheries
Zhe Yu, Lei Zhao, Jun-Liang Zhao, Wanxin Xu, Zehao Guo, Ai-Zhong Zhang, Mu-Yang Li
Summary: The study showed that dietary supplementation with TMP can significantly improve the growth, digestive enzyme activity, immune response, and antioxidant status in Jian carp, and regulate the expression of NF-KB, Nrf2, and TOR signaling pathway-related genes.
Article
Multidisciplinary Sciences
Yugang Zhang, Zhewang Lin, Julia Zhu, Miao Wang, Hening Lin
Summary: Diphthamide, a modification unique to translation elongation factor 2 (EF2), suppresses -1 frameshifting in translation and affects the TORC1/mTORC1 signaling pathway. In yeast, diphthamide deficiency inhibits the translation of TORC1-activating proteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Fisheries
Liansheng Wang, Ze Fan, Di Wu, Jinnan Li, Qiyou Xu, Linghong Miao, Xianping Ge, Dingcheng Cao, Xianhu Zheng
Summary: The effect of dietary a-ketoglutarate (AKG) on the growth performance, digestive enzymes, tor signaling pathway, and intestinal microbiota of juvenile mirror carp fed low phosphorus diets was evaluated. The results showed that AKG and phosphorus significantly improved growth performance and reduced feed conversion ratio. AKG also increased crude protein, crude ash, and phosphorous content. The activities of trypsin were enhanced by AKG and phosphorus. The expression of tor, igf-I, and gh genes were increased by AKG and phosphorus. Dietary phosphorus levels influenced the composition and abundance of intestinal microbiota.
Article
Agriculture, Multidisciplinary
Lele Fu, Haokun Liu, Wanjie Cai, Dong Han, Xiaoming Zhu, Yunxia Yang, Shouqi Xie
Summary: The study demonstrates that dietary supplementation of 0.1% OI significantly improves the growth performance of gibel carp, reduces inflammation in different organs, and regulates Ppar gamma expression through Nrf2 activation, thereby alleviating foodborne intestinal and hepatic inflammation as well as abnormal glycolipid metabolism.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Ling Wang, Yue-Qin Zeng, Juan-Hua Gu, Rui Song, Peng-Hui Cang, Yong-Xuan Xu, Xiao-xia Shao, Li-Jin Pu, Hai-Yun Luo, Xin-Fu Zhou
Summary: Oxidative stress plays a crucial role in diabetic cardiomyopathy, and the novel oral edaravone (OED) has shown potential in alleviating oxidative stress and improving diastolic dysfunction. OED reduced oxidative stress and improved cardiac parameters in type 2 diabetic rats, as well as reduced reactive oxygen species and cell damage in H9c2 cells. These effects were mediated by the activation of the Nrf2 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Plant Sciences
Cintia Pereyra, Rodrigo Parola, Ana Paula Lando, Marianela Rodriguez, Giselle Maria Astrid Martinez-Noel
Summary: Sugars are both energy sources and central molecular signals that regulate growth, development, and response to environmental stresses. Different types and concentrations of sugars have different effects on TOR signaling, with sucrose, glucose, and to a lesser extent fructose inducing root apical meristem reactivation and TOR activity. High concentration of glucose does not induce RAM or kinase activity, while sucrose-induced TOR activity requires auxin signaling.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Cell Biology
Yue Liu, Haixia Yu, Yanlin Guo, Dong Huang, Jiahuan Liu, Mingzhu Pan, Liu Wang, Wenbing Zhang, Kangsen Mai
Summary: The study demonstrated that arginine can regulate the TOR signaling pathway in abalone through SLC38A9, highlighting the significance of this pathway in abalone research.
Review
Plant Sciences
Manuel J. Mallen-Ponce, Maria Esther Perez-Perez, Jose L. Crespo
Summary: Microalgae are photosynthetic microorganisms widely distributed on Earth and they play an important role in oxygen production and food chains. Recent studies have identified a protein called TOR, which regulates cell growth and nutrient sensing in microalgae. Conservation of TOR signaling pathway has been found in diverse microalgae.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Liyun Wu, Wenjie Xu, Hongyan Li, Bo Dong, Hancheng Geng, Junyan Jin, Dong Han, Haokun Liu, Xiaoming Zhu, Yunxia Yang, Shouqi Xie
Summary: Previous studies have shown that vitamin C has a protective effect in fish. In this study, it was found that vitamin C can attenuate oxidative damage, inflammation, and acute hypoxia-induced apoptosis in gibel carp. This protective mechanism is mediated through the activation of the Nrf2/Keap1 signaling pathway. These findings provide new insights into the defense strategies of fish under hypoxic conditions.
Review
Chemistry, Medicinal
Milad Ashrafizadeh, Zahra Ahmadi, Habib Yaribeygi, Thozhukat Sathyapalan, Amirhossein Shaebkar
Summary: Astaxanthin, a naturally occurring compound, has various beneficial activities including antioxidant, anti-inflammatory, and anti-tumor effects. Although the exact protective mechanisms are unclear, the Nrf2 signaling pathway may play a critical role in these effects.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)