Cross-linking-enhanced and ultrasound-mediated drug delivery: From fabrication, mechanisms to translations

The ever-growing development of advanced biomaterials has substantially influenced the diagnosis and treatment against various diseases. In this study, a novel type of bio-inspired cross-linked polymer has been constructed with prominent size-tunability from micro- to nano-dimension and versatile enhanced drug loading mechanisms. In the meanwhile, this functional polymer has been applied to sustained and ultrasound (US)-triggered/promoted stimuli-responsive drug release upon an external US irradiation. Proof-of-principle in vivo animal studies proved their utility as a useful tool for a precision assessment of drug deposition and targeting delivery as well as a state-of-the-art visualized therapeutic strategy by this means. These valuable merits validated the as-reported functional polymer a useful tool for the precision assessment of drug deposition and targeted delivery, and also opened up an era to the state-of-the-art visualized therapeutic translations. (C) 2020 Elsevier Ltd. All rights reserved.

Automated summary

The development of advanced biomaterials has greatly influenced diagnosis and treatment against diseases, with a novel bio-inspired polymer demonstrating size-tunability and enhanced drug loading mechanisms. This functional polymer has been successfully utilized for drug release and in vivo animal studies, proving its utility for precision assessment of drug deposition and targeting delivery.