Extracellular vesicles from recombinant cell factories improve the activity and efficacy of enzymes defective in lysosomal storage disorders

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

(2020) Bhagyashree S. Joshi et al.   ACS Nano

Specific and Non-Invasive Fluorescent Labelling of Extracellular Vesicles for Evaluation of Intracellular Processing by Intestinal Epithelial Cells

(2020) Maria S. Hansen et al.   Biomedicines

FACTs Fabry gene therapy clinical trial: Two-year data

(2019) Jeffrey A. Medin et al.   MOLECULAR GENETICS AND METABOLISM

TPP1 Delivery to Lysosomes with Extracellular Vesicles and their Enhanced Brain Distribution in the Animal Model of Batten Disease

(2019) Matthew J. Haney et al.   Advanced Healthcare Materials

Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury

(2019) Shaowei Guo et al.   ACS Nano

Lysosomal N -acetyltransferase interacts with ALIX and is detected in extracellular vesicles

(2018) Anthony O. Fedele et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Detailed analysis of the plasma extracellular vesicle proteome after separation from lipoproteins

(2018) Nasibeh Karimi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Extracellular vesicles protect glucuronidase model enzymes during freeze-drying

(2018) Julia Frank et al.   Scientific Reports

Rapid and accurate analysis of stem cell-derived extracellular vesicles with super resolution microscopy and live imaging

(2018) Zubair Nizamudeen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lysosomal storage diseases

(2018) Frances M. Platt et al.   Nature Reviews Disease Primers

Tangential Flow Filtration for Highly Efficient Concentration of Extracellular Vesicles from Large Volumes of Fluid

(2018) Sara Busatto et al.   Cells

How close are we to therapies for Sanfilippo disease?

(2017) Lidia Gaffke et al.   METABOLIC BRAIN DISEASE

Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading

(2017) Dhruvitkumar S. Sutaria et al.   PHARMACEUTICAL RESEARCH

Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

(2017) Jialei Yang et al.   Molecular Therapy-Nucleic Acids

Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34 + Cells for Correction of Fabry Disease

(2017) Ju Huang et al.   Molecular Therapy-Methods & Clinical Development

Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography

(2017) Giulia Corso et al.   Scientific Reports

Highly Versatile Polyelectrolyte Complexes for Improving the Enzyme Replacement Therapy of Lysosomal Storage Disorders

(2016) Marina I. Giannotti et al.   ACS Applied Materials & Interfaces

α-Galactosidase delivery using 30Kc19-human serum albumin nanoparticles for effective treatment of Fabry disease

(2016) Hong Jai Lee et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Exploitation of Exosomes as Nanocarriers for Gene-, Chemo-, and Immune-Therapy of Cancer

(2016) Akhil Srivastava et al.   Journal of Biomedical Nanotechnology

Oral pharmacological chaperone migalastat compared with enzyme replacement therapy in Fabry disease: 18-month results from the randomised phase III ATTRACT study

(2016) Derralynn A Hughes et al.   JOURNAL OF MEDICAL GENETICS

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

(2016) Defang Li et al.   Nature Communications

α-Galactosidase-A Loaded-Nanoliposomes with Enhanced Enzymatic Activity and Intracellular Penetration

(2016) Ingrid Cabrera et al.   Advanced Healthcare Materials

Trehalose prevents aggregation of exosomes and cryodamage

(2016) Steffi Bosch et al.   Scientific Reports

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Using exosomes, naturally-equipped nanocarriers, for drug delivery

(2015) Elena V. Batrakova et al.   JOURNAL OF CONTROLLED RELEASE

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

(2015) Edward J. Goetzl et al.   NEUROLOGY

Polymer Capsules as a Theranostic Tool for a Universal In Vitro Screening Assay-The Case of Lysosomal Storage Diseases

(2015) Moritz Nazarenus et al.   PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

Extracellular Vesicles as Therapeutic Tools in Cardiovascular Diseases

(2014) Audrey Fleury et al.   Frontiers in Immunology

Recent advances in mammalian protein production

(2013) Ashok D. Bandaranayake et al.   FEBS LETTERS

Enhancing Biodistribution of Therapeutic Enzymes In Vivo by Modulating Surface Coating and Concentration of ICAM-1-Targeted Nanocarriers

(2013) Janet Hsu et al.   Journal of Biomedical Nanotechnology

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Cell Size and Velocity of Injection are Major Determinants of the Safety of Intracarotid Stem Cell Transplantation

(2013) Miroslaw Janowski et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

New biotechnological and nanomedicine strategies for treatment of lysosomal storage disorders

(2010) Silvia Muro   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Enzyme replacement therapy with agalsidase alfa in patients with Fabry's disease: an analysis of registry data

(2009) A Mehta et al.   LANCET

Vasculopathy in patients with Fabry disease: Current controversies and research directions

(2009) S.M. Rombach et al.   MOLECULAR GENETICS AND METABOLISM

Intracarotid Delivery of Drugs

(2008) Shailendra Joshi et al.   ANESTHESIOLOGY

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY