Article
Biochemistry & Molecular Biology
Yuehui Jia, Ruixiang Wang, Guijin Li, Chen Feng, Lei Qi, Yuanyuan Wang, Shengqi Su, Yuanjie Zou, Xu Liu, Yanan Wang, Yiyi Zhang, Linlin Du, Huixin Sun, Shuxiu Hao, Jie Hou, Hongqi Feng, Qi Li, Tong Wang
Summary: This research aimed to provide evidence for the prevention, control, and elimination of Keshan disease (KD) by assessing the selenium nutrition levels of residents. The study found that the hair selenium levels of inhabitants in KD endemic areas were significantly lower compared to non-endemic areas, and a higher proportion of residents in KD endemic areas were selenium-deficient or marginally deficient. Provinces such as Shannxi, Heilongjiang, and Gansu should be given high priority in KD prevention and control.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Nutrition & Dietetics
Jie Hou, Lifang Zhu, Shuran Jin, Jinshu Li, Zhifeng Xing, Yanling Wang, Xiaoyan Wan, Xianni Guo, Anwei Wang, Xiuhong Wang, Jinming Liu, Jing Ma, Shuang Zhou, Xiangdong Zhang, Heming Zheng, Jianhui Wang, Hongqi Feng, Shuqiu Sun, Tong Wang
Summary: This study investigated the prevalence of hypertension in KD-endemic and non-endemic areas and found that the prevalence was higher in the KD-endemic areas, especially in men and in the northern regions. Additionally, there was a positive correlation between hypertension prevalence and per capita GDP. Therefore, adopting a healthy diet, including high consumption of vegetables and foods rich in selenium, may help prevent and control hypertension in these areas.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Yuanjie Zou, Xu Liu, Tong Wang, Yanan Wang, Shan Han, Yiyi Zhang, Shengqi Su, Huihui Zhou, Xiao Zhang, Hong Liang, Yuehui Jia, Lei Qi, Yuanyuan Wang, Ruixiang Wang
Summary: By mapping the spatial distribution of hair selenium levels, this study found that residents in KD-endemic areas had significantly lower selenium levels compared to non-endemic areas. The residents' hair selenium levels showed spatial clustering, indicating a possible selenium deficiency among residents in KD-endemic areas.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jichang Huang, Chenqing Zheng, Rong Luo, Xin Cao, Mingjiang Liu, Qingquan Gu, Feng Li, Jinshu Li, Xiushan Wu, Zhenglin Yang, Xia Shen, Xiaoping Li
Summary: In this study, the selenium-related gene ALAD was identified as the causative gene for Keshan disease. ALAD was found to be essential for maintaining normal mitochondrial activity and cardiac function. These findings provide strong molecular evidence supporting the hypothesis of selenium deficiency in Keshan disease.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jie Hou, Lifang Zhu, Cuicui Chen, Hongqi Feng, Dandan Li, Shuqiu Sun, Zhifeng Xing, Xiaoyan Wan, Xiuhong Wang, Feng Li, Xianni Guo, Peisheng Xiong, Shengcheng Zhao, Shujuan Li, Jinming Liu, Dianjun Sun
Summary: This study found that residents in areas with a high prevalence of Keshan disease are selenium-deficient, and the low selenium levels are associated with KD control. Increasing the supply of staple foods containing selenium levels exceeding 0.025 mg/kg may contribute to the control and prevention of KD.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Nutrition & Dietetics
Yuehui Jia, Guijin Li, Ruixiang Wang, Chen Feng, Lei Qi, Yuanyuan Wang, Shengqi Su, Yuanjie Zou, Xu Liu, Yanan Wang, Yiyi Zhang, Linlin Du, Huixin Sun, Shuxiu Hao, Jie Hou, Hongqi Feng, Qi Li, Tong Wang
Summary: This study conducted a spatial ecological analysis to assess the relationship between hair selenium levels and Keshan disease nationwide. The results showed that the residents in Keshan disease endemic counties had significantly lower hair selenium levels compared to non-endemic counties, and hair selenium levels were positively correlated with per capita GDP.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Yuehui Jia, Ruixiang Wang, Shengqi Su, Lei Qi, Yuanyuan Wang, Yanan Wang, Yuanjie Zou, Xu Liu, Yiyi Zhang, Jie Hou, Hongqi Feng, Qi Li, Tong Wang
Summary: This study provided geographically precise evidence of selenium nutrition at the molecular level to assess KD prevention and control. The globally clustered SELENOP levels and identification of cold spots in KD endemic provinces highlight the importance of precision prevention and control efforts.
FRONTIERS IN NUTRITION
(2022)
Review
Food Science & Technology
Kewei Wang, Shoujun Liu, Xufeng Zhang, Dianjun Sun
Summary: Mycotoxins can cause myocardial injury and are associated with the pathogenic mechanism of cardiovascular diseases such as endemic Keshan disease, beriberi, and atherosclerosis.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Xu Liu, Yanan Wang, Shan Han, Yiyi Zhang, Yuanjie Zou, Shengqi Su, Huihui Zhou, Xiao Zhang, Hong Liang, Jie Hou, Tong Wang
Summary: This study aimed to conduct a spatial assessment of Keshan disease elimination at the level of the etiological molecular marker, and found that serum selenium levels were positively correlated with per capita gross domestic product in Heilongjiang Province.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Genetics & Heredity
Alec Reginald Errol Correa, Kamal Naini, Pallavi Mishra, Vatsla Dadhwal, Ramesh Agarwal, Rashmi Shukla, Madhulika Kabra, Neerja Gupta
Summary: This study assessed the etiological spectrum of nonimmune hydrops fetalis and found that fetal whole exome sequencing was useful for diagnosing the causes in an Indian cohort. A genetic etiology was identified in a significant percentage of the fetuses, with novel variants detected in several genes. Only a small percentage of the cohort survived without morbidity.
PRENATAL DIAGNOSIS
(2021)
Review
Immunology
Colin F. Craig, Rhiannon T. Filippone, Rhian Stavely, Joel C. Bornstein, Vasso Apostolopoulos, Kulmira Nurgali
Summary: Patients with inflammatory bowel disease (IBD) have higher rates of depression, possibly due to inflammation in the central nervous system. Intestinal inflammation and dysfunction may lead to reduced intestinal permeability, allowing enterotoxins to enter the bloodstream and affect non-intestinal tissues like the brain.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Microbiology
Maria Teresa Llorente, Raquel Escudero, Raquel Ramiro, Maria Antonia Remacha, Rocio Martinez-Ruiz, Fatima Galan-Sanchez, Monica de Frutos, Matilde Elia, Isabel Onrubia, Sergio Sanchez
Summary: This study aimed to investigate the occurrence of enteroaggregative Escherichia coli (EAEC) in patients with non-travel related diarrhea in Spain and to characterize the molecular features of EAEC strains associated with illness in this high-income setting. The results showed that EAEC was the only bacterial enteric pathogen detected in a significant proportion of cases of endemic diarrhea in Spain, especially in children under 5 years old. Some of these strains also had a potential pathogenicity in the urinary/systemic system.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Karen Sliwa, Charle Andre Viljoen, Babar Hasan, Ntobeko A. B. Ntusi
Summary: This article provides an overview of recent research on cardiomyopathies and nutritional heart disease that are more prevalent in tropical regions. The development of these diseases is complicated by poverty, fragmented healthcare systems, and limited access to healthcare due to socioeconomic inequalities. This review proposes an approach for diagnosing and caring for patients with suspected or confirmed tropical cardiomyopathies and nutritional heart disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yanan Wang, Yuanjie Zou, Tong Wang, Shan Han, Xu Liu, Yiyi Zhang, Shengqi Su, Huihui Zhou, Xiao Zhang, Hong Liang
Summary: This study investigated the serum SELENOP levels in residents of KD endemic and non-endemic counties in Heilongjiang province, China. Results showed that some KD endemic counties still have selenium deficiency, with higher serum SELENOP levels in non-endemic areas positively correlated with per capita GDP. Including selenium in the national surveillance of KD could provide more evidence for the assessment of KD elimination.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Medicine, General & Internal
Raj R. Makkar, Sung-Han Yoon, Tarun Chakravarty, Samir R. Kapadia, Amar Krishnaswamy, Pinak B. Shah, Tsuyoshi Kaneko, Eric R. Skipper, Michael Rinaldi, Vasilis Babaliaros, Sreekanth Vemulapalli, Alfredo Trento, Wen Cheng, Susheel Kodali, Michael J. Mack, Martin B. Leon, Vinod H. Thourani
Summary: The study compared outcomes of TAVR for bicuspid vs tricuspid aortic stenosis in patients at low surgical risk and found no significant differences in mortality or stroke at 30 days or 1 year between the two groups. Further randomized trials are needed to fully evaluate the safety and efficacy of TAVR for bicuspid aortic stenosis.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)