Immune Responses to Pseudomonas aeruginosa Biofilm Infections

The extracellular polysaccharide matrix of Pseudomonas aeruginosa biofilms is a determinant of polymorphonuclear leukocyte responses

(2020) Morten Rybtke et al.   INFECTION AND IMMUNITY

Azithromycin potentiates avian IgY effect against Pseudomonas aeruginosa in a murine pulmonary infection model

(2020) Kim Thomsen et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Bacterial aggregate size determines phagocytosis efficiency of polymorphonuclear leukocytes

(2020) Maria Alhede et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Secretory IgA-mediated immune response in saliva and early detection of Pseudomonas aeruginosa in the lower airways of pediatric cystic fibrosis patients

(2019) Renan Marrichi Mauch et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents—How P. aeruginosa Can Escape Antibiotics

(2019) Oana Ciofu et al.   Frontiers in Microbiology

Synergistic effect of immunomodulatory S100A8/A9 and ciprofloxacin against Pseudomonas aeruginosa biofilm in a murine chronic wound model

(2019) Anne Sofie Boe Laulund et al.   Pathogens and Disease

Pseudomonas aeruginosa Interstrain Dynamics and Selection of Hyperbiofilm Mutants during a Chronic Infection

(2019) Erin S. Gloag et al.   mBio

The Immune Response to Chronic Pseudomonas aeruginosa Wound Infection in Immunocompetent Mice

(2019) Johanna M. Sweere et al.   Advances in Wound Care

The Leucopatch®System in the Management of Hard-to-Heal Diabetic Foot Ulcers—A Multicentre, Multinational, Observer-Blinded, Randomised Controlled Trial

(2018) FRANCES GAME et al.   DIABETES

Pseudomonas aeruginosa rugose small-colony variants evade host clearance, are hyper-inflammatory, and persist in multiple host environments

(2018) Matthew J. Pestrak et al.   PLoS Pathogens

Psl Produced by Mucoid Pseudomonas aeruginosa Contributes to the Establishment of Biofilms and Immune Evasion

(2017) Christopher J. Jones et al.   mBio

Activation of pulmonary and lymph node dendritic cells during chronicPseudomonas aeruginosalung infection in mice

(2016) Dina Silke Malling Damlund et al.   APMIS

S100A8/A9 is an important host defence mediator in neuropathic foot ulcers in patients with type 2 diabetes mellitus

(2016) Hannah Trøstrup et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Antimicrobial Peptides and Innate Lung Defenses

(2016) Pieter S. Hiemstra et al.   CHEST

The phagocytic fitness of leucopatches may impact the healing of chronic wounds

(2016) K. Thomsen et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Innate and Adaptive Immunity in Cystic Fibrosis

(2016) Emanuela M. Bruscia et al.   CLINICS IN CHEST MEDICINE

Antimicrobial peptides

(2016) Ling-juan Zhang et al.   CURRENT BIOLOGY

Protein Network of the Pseudomonas aeruginosa Denitrification Apparatus

(2016) José Manuel Borrero-de Acuña et al.   JOURNAL OF BACTERIOLOGY

Anti- Pseudomonas aeruginosa IgY antibodies augment bacterial clearance in a murine pneumonia model

(2016) K. Thomsen et al.   Journal of Cystic Fibrosis

Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles

(2016) Lisa M. Connor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses

(2016) Mariena J. A. van der Plas et al.   Nature Communications

Anti-Pseudomonas aeruginosaIgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils

(2016) Kim Thomsen et al.   Human Vaccines & Immunotherapeutics

Pseudomonas aeruginosa Airway Infection Recruits and Modulates Neutrophilic Myeloid-Derived Suppressor Cells

(2016) Hasan H. Öz et al.   Frontiers in Cellular and Infection Microbiology

Regulatory T-Cell Impairment in Cystic Fibrosis Patients with ChronicPseudomonasInfection

(2015) Andreas Hector et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ESCMID∗ guideline for the diagnosis and treatment of biofilm infections 2014

(2015) N. Høiby et al.   CLINICAL MICROBIOLOGY AND INFECTION

Small colony variants ofPseudomonas aeruginosain chronic bacterial infection of the lung in cystic fibrosis

(2015) Thomas J Evans   Future Microbiology

Anti-Pseudomonas aeruginosa IgY Antibodies Induce Specific Bacterial Aggregation and Internalization in Human Polymorphonuclear Neutrophils

(2015) K. Thomsen et al.   INFECTION AND IMMUNITY

Cystic fibrosis-adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses

(2015) S. L. LaFayette et al.   Science Advances

Pseudomonas aeruginosabiofilm infections: From molecular biofilm biology to new treatment possibilities

(2014) Tim Tolker-Nielsen   APMIS

Nitric oxide production by polymorphonuclear leucocytes in infected cystic fibrosis sputum consumes oxygen

(2014) M. Kolpen et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

Polymorphonuclear Leukocytes Restrict Growth of Pseudomonas aeruginosa in the Lungs of Cystic Fibrosis Patients

(2014) Kasper N. Kragh et al.   INFECTION AND IMMUNITY

TLR Expression on Neutrophils at the Pulmonary Site of Infection: TLR1/TLR2-Mediated Up-Regulation of TLR5 Expression in Cystic Fibrosis Lung Disease

(2014) B. Koller et al.   JOURNAL OF IMMUNOLOGY

Periodontitis

(2014) Christoph Schaudinn et al.   JOURNAL OF THE AMERICAN DENTAL ASSOCIATION

T Helper Cell Subsets Specific for Pseudomonas aeruginosa in Healthy Individuals and Patients with Cystic Fibrosis

(2014) Hannah K. Bayes et al.   PLoS One

Nitrous Oxide Production in Sputum from Cystic Fibrosis Patients with Chronic Pseudomonas aeruginosa Lung Infection

(2014) Mette Kolpen et al.   PLoS One

pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37

(2014) Mahmoud H. Abou Alaiwa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum

(2014) Laura Line et al.   Frontiers in Microbiology

A Th17- and Th2-skewed Cytokine Profile in Cystic Fibrosis Lungs Represents a Potential Risk Factor forPseudomonas aeruginosaInfection

(2013) Kerstin Tiringer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Flagellin Induces Myeloid-Derived Suppressor Cells: Implications for Pseudomonas aeruginosa Infection in Cystic Fibrosis Lung Disease

(2013) N. Rieber et al.   JOURNAL OF IMMUNOLOGY

Pseudomonas aeruginosabiofilm aggravates skin inflammatory response in BALB/c mice in a novel chronic wound model

(2013) Hannah Trøstrup et al.   WOUND REPAIR AND REGENERATION

Expression of Fap amyloids inPseudomonas aeruginosa,P. fluorescens,andP. putidaresults in aggregation and increased biofilm formation

(2013) Morten S. Dueholm et al.   MicrobiologyOpen

Multi-Faceted Functions of Secretory IgA at Mucosal Surfaces

(2013) Blaise Corthésy   Frontiers in Immunology

Alarmins: awaiting a clinical response

(2012) James K. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

Sputum neutrophils in cystic fibrosis patients display a reduced respiratory burst

(2012) Neralee Houston et al.   Journal of Cystic Fibrosis

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

(2012) Alejandro A. Pezzulo et al.   NATURE

Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections

(2012) Balázs Rada et al.   TRENDS IN MICROBIOLOGY

Characteristics of an autologous leukocyte and platelet-rich fibrin patch intended for the treatment of recalcitrant wounds

(2012) Rasmus Lundquist et al.   WOUND REPAIR AND REGENERATION

S100A8/A9 deficiency in nonhealing venous leg ulcers uncovered by multiplexed antibody microarray profiling

(2011) H. Trøstrup et al.   BRITISH JOURNAL OF DERMATOLOGY

Pseudomonas aeruginosa Psl polysaccharide reduces neutrophil phagocytosis and the oxidative response by limiting complement-mediated opsonization

(2011) Meenu Mishra et al.   CELLULAR MICROBIOLOGY

Antimicrobial Peptides: Old Molecules with New Ideas

(2011) Teruaki Nakatsuji et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Success Rate of Split-Thickness Skin Grafting of Chronic Venous Leg Ulcers Depends on the Presence of Pseudomonas aeruginosa: A Retrospective Study

(2011) Trine Høgsberg et al.   PLoS One

Quantitative analysis of the cellular inflammatory response against biofilm bacteria in chronic wounds

(2011) Mustafa Fazli et al.   WOUND REPAIR AND REGENERATION

The clinical impact of bacterial biofilms

(2011) Niels Høiby et al.   International Journal of Oral Science

An update onPseudomonas aeruginosabiofilm formation, tolerance, and dispersal

(2010) Morten Harmsen et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

The immune system vs.Pseudomonas aeruginosabiofilms

(2010) Peter Østrup Jensen et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Lactate in cystic fibrosis sputum

(2010) Tobias Bensel et al.   Journal of Cystic Fibrosis

Pseudomonas aeruginosauses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix

(2010) Bradley R. Borlee et al.   MOLECULAR MICROBIOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

The Pseudomonas aeruginosa Exopolysaccharide Psl Facilitates Surface Adherence and NF- B Activation in A549 Cells

(2010) M. S. Byrd et al.   mBio

YfiBNR Mediates Cyclic di-GMP Dependent Small Colony Variant Formation and Persistence in Pseudomonas aeruginosa

(2010) Jacob G. Malone et al.   PLoS Pathogens

Osteomyelitis and the role of biofilms in chronic infection

(2009) Rebecca A. Brady et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Pseudomonas aeruginosaquorum-sensing signal molecules interfere with dendritic cell-induced T-cell proliferation

(2009) Mette E. Skindersoe et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Flagellum-Mediated Biofilm Defense Mechanisms of Pseudomonas aeruginosa against Host-Derived Lactoferrin

(2009) J. G. Leid et al.   INFECTION AND IMMUNITY

Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa

(2009) M. van Gennip et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Pseudomonas aeruginosa Rugose Small-Colony Variants Have Adaptations That Likely Promote Persistence in the Cystic Fibrosis Lung

(2009) M. Starkey et al.   JOURNAL OF BACTERIOLOGY

Nonrandom Distribution of Pseudomonas aeruginosa and Staphylococcus aureus in Chronic Wounds

(2009) M. Fazli et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Neutrophil enhancement of Pseudomonas aeruginosa biofilm development: human F-actin and DNA as targets for therapy

(2009) Quinn M. Parks et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes

(2009) M. Alhede et al.   MICROBIOLOGY-SGM

Pseudomonas aeruginosabiofilms in the respiratory tract of cystic fibrosis patients

(2009) Thomas Bjarnsholt et al.   PEDIATRIC PULMONOLOGY

Pseudomonas aeruginosa LPS or Flagellin Are Sufficient to Activate TLR-Dependent Signaling in Murine Alveolar Macrophages and Airway Epithelial Cells

(2009) Eloïse Raoust et al.   PLoS One

Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis

(2009) M Kolpen et al.   THORAX

Medical biofilms

(2008) James D. Bryers   BIOTECHNOLOGY AND BIOENGINEERING

Distribution, Organization, and Ecology of Bacteria in Chronic Wounds

(2008) K. Kirketerp-Moller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression

(2008) Lucas R. Hoffman et al.   Journal of Cystic Fibrosis

The role of chloride anion and CFTR in killing of Pseudomonas aeruginosa by normal and CF neutrophils

(2008) R. G. Painter et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Characterization of bacterial DNA binding to human neutrophil surface

(2008) Juan I Fuxman Bass et al.   LABORATORY INVESTIGATION

Good effect of IgY againstPseudomonas aeruginosainfections in cystic fibrosis patients

(2008) Elin Nilsson et al.   PEDIATRIC PULMONOLOGY

Neutrophils in cystic fibrosis

(2008) D G Downey et al.   THORAX

Why chronic wounds will not heal: a novel hypothesis

(2007) Thomas Bjarnsholt et al.   WOUND REPAIR AND REGENERATION