A New E-Series Resolvin: RvE4 Stereochemistry and Function in Efferocytosis of Inflammation-Resolution

Resolvin E1 is a pro-repair molecule that promotes intestinal epithelial wound healing

(2020) Miguel Quiros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and Synthesis of Benzene Congeners of Resolvin E2, a Proresolving Lipid Mediator, as Its Stable Equivalents

(2020) Yuto Murakami et al.   ACS Medicinal Chemistry Letters

N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease

(2020) Ju Youn Lee et al.   Nature Communications

Phosphorylation of 5-LOX: The Potential Set-point of Inflammation

(2020) Zonglin He et al.   NEUROCHEMICAL RESEARCH

Synthesis of Resolvin E3, a Proresolving Lipid Mediator, and Its Deoxy Derivatives: Identification of 18-Deoxy-resolvin E3 as a Potent Anti-Inflammatory Agent

(2020) Hayato Fukuda et al.   JOURNAL OF ORGANIC CHEMISTRY

Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution

(2020) Paul M. Jordan et al.   Cell Reports

Discovery and Engineering of a Microbial Double-Oxygenating Lipoxygenase for Synthesis of Dihydroxy Fatty Acids as Specialized Proresolving Mediators

(2020) Jin Lee et al.   ACS Sustainable Chemistry & Engineering

RvE1 Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction and Enhances Bacterial Clearance

(2020) Jianmin Chen et al.   Frontiers in Immunology

Maresin-1 and Resolvin E1 Promote Regenerative Properties of Periodontal Ligament Stem Cells Under Inflammatory Conditions

(2020) Emmanuel Albuquerque-Souza et al.   Frontiers in Immunology

Human lipoxygenase isoforms form complex patterns of double and triple oxygenated compounds from eicosapentaenoic acid

(2020) Laura Kutzner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial)

(2019) Joel L. Ramirez et al.   JOURNAL OF SURGICAL RESEARCH

Resolvin E3 attenuates allergic airway inflammation via the interleukin-23–interleukin-17A pathway

(2019) Makiko Sato et al.   FASEB JOURNAL

HMGB1–C1q complexes regulate macrophage function by switching between leukotriene and specialized proresolving mediator biosynthesis

(2019) Tianye Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of weight loss on neutrophil resolvins in the metabolic syndrome

(2019) A. Barden et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Regulation of Apoptotic Cell Clearance During Resolution of Inflammation

(2019) Simone Arienti et al.   Frontiers in Pharmacology

Resolution metabolomes activated by hypoxic environment

(2019) Paul C. Norris et al.   Science Advances

Enriched Marine Oil Supplements Increase Peripheral Blood Specialized Pro-Resolving Mediators Concentrations and Reprogram Host Immune Responses

(2019) Patricia R. Souza et al.   CIRCULATION RESEARCH

Biosynthetic metabolomes of cysteinyl-containing immunoresolvents

(2019) Charlotte C. Jouvene et al.   FASEB JOURNAL

ERV1/ChemR23 Signaling Protects from Atherosclerosis by Modifying oxLDL Uptake and Phagocytosis in Macrophages

(2018) Andres Laguna-Fernandez et al.   CIRCULATION

Impaired Production and Diurnal Regulation of Vascular RvDn-3 DPAIncrease Systemic Inflammation and Cardiovascular DiseaseNovelty and Significance

(2018) Romain A. Colas et al.   CIRCULATION RESEARCH

Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimer's disease

(2018) Alpdogan Kantarci et al.   EXPERIMENTAL NEUROLOGY

Leukotriene biosynthetic enzymes as therapeutic targets

(2018) Jesper Z. Haeggström   JOURNAL OF CLINICAL INVESTIGATION

Supplementation with eicosapentaenoic acid and docosahexaenoic acid reduces high levels of circulating proinflammatory cytokines in aging adults: A randomized, controlled study

(2018) Alai Tan et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

The effects of alcohol on plasma lipid mediators of inflammation resolution in patients with Type 2 diabetes mellitus

(2018) Anne Barden et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

(2018) Oliver Werz et al.   Nature Communications

An omega-3 polyunsaturated fatty acid derivative, 18-HEPE, protects against CXCR4-associated melanoma metastasis

(2018) Jieping Li et al.   CARCINOGENESIS

Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice

(2018) Satoshi Deyama et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Resolvin E1 attenuates murine psoriatic dermatitis

(2018) Yu Sawada et al.   Scientific Reports

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia

(2018) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

The importance of being “pure” neutrophils

(2017) Federica Calzetti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Resolvins suppress tumor growth and enhance cancer therapy

(2017) Megan L. Sulciner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23

(2017) Satoshi Deyama et al.   PSYCHOPHARMACOLOGY

Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes

(2016) Marcelo O. Freire et al.   JOURNAL OF IMMUNOLOGY

Resolvin E1 Reverses Experimental Periodontitis and Dysbiosis

(2016) Chun-Teh Lee et al.   JOURNAL OF IMMUNOLOGY

Tissue biology perspective on macrophages

(2016) Yasutaka Okabe et al.   NATURE IMMUNOLOGY

Specialised pro-resolving mediators of inflammation in inflammatory arthritis

(2016) Anne E. Barden et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

(2015) Olof Rådmark et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses

(2015) Yu Sawada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human milk proresolving mediators stimulate resolution of acute inflammation

(2015) H Arnardottir et al.   Mucosal Immunology

Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections

(2015) Jesmond Dalli et al.   NATURE MEDICINE

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload–induced maladaptive cardiac remodeling

(2014) Jin Endo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphorylation of 5-Lipoxygenase at Ser523 by Protein Kinase A Determines Whether Pioglitazone and Atorvastatin Induce Proinflammatory Leukotriene B4 or Anti-Inflammatory 15-Epi-Lipoxin A4 Production

(2014) Y. Ye et al.   JOURNAL OF IMMUNOLOGY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Neutrophils at work

(2014) William M Nauseef et al.   NATURE IMMUNOLOGY

Stereochemical assignment and anti-inflammatory properties of the omega-3 lipid mediator resolvin E3

(2013) Y. Isobe et al.   JOURNAL OF BIOCHEMISTRY

Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth

(2013) Aki Yamashita et al.   Scientific Reports

Identification and Structure Determination of Novel Anti-inflammatory Mediator Resolvin E3, 17,18-Dihydroxyeicosapentaenoic Acid

(2012) Yosuke Isobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resolvin E2 Formation and Impact in Inflammation Resolution

(2012) S. F. Oh et al.   JOURNAL OF IMMUNOLOGY

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

(2011) Sungwhan F. Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

NK Cells Are Effectors for Resolvin E1 in the Timely Resolution of Allergic Airway Inflammation

(2011) O. Haworth et al.   JOURNAL OF IMMUNOLOGY

Resolvin D2 Is a Potent Endogenous Inhibitor for Transient Receptor Potential Subtype V1/A1, Inflammatory Pain, and Spinal Cord Synaptic Plasticity in Mice: Distinct Roles of Resolvin D1, D2, and E1

(2011) C.-K. Park et al.   JOURNAL OF NEUROSCIENCE

n–3 Fatty Acids in Cardiovascular Disease

(2011) Raffaele De Caterina   NEW ENGLAND JOURNAL OF MEDICINE

Aspirin-Triggered Lipoxin and Resolvin E1 Modulate Vascular Smooth Muscle Phenotype and Correlate with Peripheral Atherosclerosis

(2010) Karen J. Ho et al.   AMERICAN JOURNAL OF PATHOLOGY

Resolvin E1 protects the rat heart against reperfusion injury

(2010) K. T. Keyes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Resolvin E1 Regulates Adenosine Diphosphate Activation of Human Platelets

(2010) Gabrielle Fredman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Controlling Herpes Simplex Virus-Induced Ocular Inflammatory Lesions with the Lipid-Derived Mediator Resolvin E1

(2010) N. K. Rajasagi et al.   JOURNAL OF IMMUNOLOGY

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

(2010) Zhen-Zhong Xu et al.   NATURE MEDICINE

Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification

(2010) E. L. Campbell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The endogenous pro-resolving mediators lipoxin A4 and resolvin E1 preserve organ function in allograft rejection

(2010) Bruce D. Levy et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Obesity-induced insulin resistance and hepatic steatosis are alleviated by ω-3 fatty acids: a role for resolvins and protectins

(2009) Ana González-Périz et al.   FASEB JOURNAL