18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload–induced maladaptive cardiac remodeling

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Stereochemical assignment and anti-inflammatory properties of the omega-3 lipid mediator resolvin E3

(2013) Y. Isobe et al.   JOURNAL OF BIOCHEMISTRY

Resolvins: Anti-Inflammatory and Proresolving Mediators Derived from Omega-3 Polyunsaturated Fatty Acids

(2012) Michael J. Zhang et al.   Annual Review of Nutrition

Mediator lipidomics in acute inflammation and resolution

(2012) M. Arita   JOURNAL OF BIOCHEMISTRY

Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis

(2012) Florian Leuschner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intra-articular lentivirus-mediated insertion of the fat-1 gene ameliorates osteoarthritis

(2012) Min-jun Huang et al.   MEDICAL HYPOTHESES

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Myofibroblast-mediated mechanisms of pathological remodelling of the heart

(2012) Karl T. Weber et al.   Nature Reviews Cardiology

Macrophage-Stimulated Cardiac Fibroblast Production of IL-6 Is Essential for TGF β/Smad Activation and Cardiac Fibrosis Induced by Angiotensin II

(2012) Feifei Ma et al.   PLoS One

Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF- 

(2011) K. H. Weylandt et al.   CARCINOGENESIS

Omega-3 Fatty Acids Prevent Pressure Overload–Induced Cardiac Fibrosis Through Activation of Cyclic GMP/Protein Kinase G Signaling in Cardiac Fibroblasts

(2011) Jinghai Chen et al.   CIRCULATION

Effects of n-3 Polyunsaturated Fatty Acids on Left Ventricular Function and Functional Capacity in Patients With Dilated Cardiomyopathy

(2011) Savina Nodari et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Omega-3 Fatty Acids and Cardiovascular Disease

(2011) Dariush Mozaffarian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Endogenously Decreasing Tissue n-6/n-3 Fatty Acid Ratio Reduces Atherosclerotic Lesions in Apolipoprotein E –Deficient Mice by Inhibiting Systemic and Vascular Inflammation

(2010) Jian-Bo Wan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Transgenic Restoration of Long-Chain n-3 Fatty Acids in Insulin Target Tissues Improves Resolution Capacity and Alleviates Obesity-Linked Inflammation and Insulin Resistance in High-Fat-Fed Mice

(2010) P. J. White et al.   DIABETES

Interleukin 6 Mediates Myocardial Fibrosis, Concentric Hypertrophy, and Diastolic Dysfunction in Rats

(2010) Giselle C. Meléndez et al.   HYPERTENSION

Cardiac 12/15 lipoxygenase–induced inflammation is involved in heart failure

(2009) Yosuke Kayama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Total Synthesis and Bioactivity of Resolvin E2

(2009) Seiji Ogawa et al.   ORGANIC LETTERS

Reduction of inflammation and chronic tissue damage by omega-3 fatty acids in fat-1 transgenic mice with pancreatitis

(2008) Karsten H. Weylandt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial

(2008) GISSI-HF investigators   LANCET