期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.606384
关键词
HCA(2); intestinal homeostasis; anti-inflammatory; intestinal inflammation; colon cancer; mucosal immunity; microbiota
类别
资金
- Auburn University, Intramural Grant Program
- Boshell Diabetes and Metabolic Diseases Research Program
HCA(2) is a vital receptor for sensing metabolic intermediates and regulating anti-inflammatory effects, serving as a therapeutic target for inflammation-associated diseases. It plays a key role in maintaining intestinal homeostasis, predominantly expressed in immune cells and intestinal epithelial cells to regulate the communication network between diet, microbiota, and immune cells.
Hydroxycarboxylic acid receptor 2 (HCA(2)) is vital for sensing intermediates of metabolism, including beta-hydroxybutyrate and butyrate. It also regulates profound anti-inflammatory effects in various tissues, indicating that HCA(2) may serve as an essential therapeutic target for mediating inflammation-associated diseases. Butyrate and niacin, endogenous and exogenous ligands of HCA(2), have been reported to play an essential role in maintaining intestinal homeostasis. HCA(2), predominantly expressed in diverse immune cells, is also present in intestinal epithelial cells (IECs), where it regulates the intricate communication network between diet, microbiota, and immune cells. This review summarizes the physiological role of HCA(2) in intestinal homeostasis and its pathological role in intestinal inflammation and cancer.
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