How do the Fat–Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours?

Prickle isoforms determine handedness of helical morphogenesis

(2020) Bomsoo Cho et al.   eLife

Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development

(2020) Abilasha Rao-Bhatia et al.   DEVELOPMENTAL CELL

Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow

(2020) Kelly L. Betterman et al.   JOURNAL OF CLINICAL INVESTIGATION

Ancestral roles of atypical cadherins in planar cell polarity

(2020) Maria Brooun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frizzled-Dependent Planar Cell Polarity without Secreted Wnt Ligands

(2020) Joyce J.S. Yu et al.   DEVELOPMENTAL CELL

No Evidence that Wnt Ligands Are Required for Planar Cell Polarity in Drosophila

(2020) Ben Ewen-Campen et al.   Cell Reports

Planar cell polarity in the larval epidermis of Drosophila and the role of microtubules

(2020) Stefano Pietra et al.   Open Biology

Oriented Cell Divisions Are Not Required for Drosophila Wing Shape

(2019) Zhenru Zhou et al.   CURRENT BIOLOGY

Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex

(2019) Andreas Gerondopoulos et al.   CURRENT BIOLOGY

Dynamic Polarization of the Multiciliated Planarian Epidermis between Body Plan Landmarks

(2019) Hanh Thi-Kim Vu et al.   DEVELOPMENTAL CELL

Fat/Dachsous family cadherins in cell and tissue organisation

(2019) Alexander D. Fulford et al.   CURRENT OPINION IN CELL BIOLOGY

Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos

(2019) Yildiz Koca et al.   Scientific Reports

Big roles for Fat cadherins

(2018) Seth Blair et al.   CURRENT OPINION IN CELL BIOLOGY

Atypical Cadherin Dachsous1b Interacts with Ttc28 and Aurora B to Control Microtubule Dynamics in Embryonic Cleavages

(2018) Jiakun Chen et al.   DEVELOPMENTAL CELL

Planar cell polarity: the prickle gene acts independently on both the Ds/Ft and the Stan/Fz systems

(2018) José Casal et al.   DEVELOPMENT

Polarized microtubule dynamics directs cell mechanics and coordinates forces during epithelial morphogenesis

(2018) Amrita Singh et al.   NATURE CELL BIOLOGY

The Dachsous/Fat/Four-Jointed Pathway Directs the Uniform Axial Orientation of Epithelial Cells in the Drosophila Abdomen

(2018) Federica Mangione et al.   Cell Reports

Forces directing germ-band extension in Drosophila embryos

(2017) Deqing Kong et al.   MECHANISMS OF DEVELOPMENT

Planar cell polarity in development and disease

(2017) Mitchell T. Butler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Planar Cell Polarity Effector Fritz Interacts with Dishevelled and Has Multiple Functions in Regulating PCP

(2017) Ying Wang et al.   G3-Genes Genomes Genetics

Atrophin controls developmental signaling pathways via interactions with Trithorax-like

(2017) Kelvin Yeung et al.   eLife

Modulation of junction tension by tumor suppressors and proto-oncogenes regulates cell-cell contacts

(2016) Floris Bosveld et al.   DEVELOPMENT

Microtubule organization is determined by the shape of epithelial cells

(2016) Juan Manuel Gomez et al.   Nature Communications

Dchs1–Fat4 regulation of polarized cell behaviours during skeletal morphogenesis

(2016) Yaopan Mao et al.   Nature Communications

Prickle isoforms control the direction of tissue polarity by microtubule independent and dependent mechanisms

(2016) Katherine A. Sharp et al.   Biology Open

Planar cell polarity: the Dachsous/Fat system contributes differently to the embryonic and larval stages ofDrosophila

(2016) Pedro Saavedra et al.   Biology Open

Round and round gets you somewhere: collective cell migration and planar polarity in elongating Drosophila egg chambers

(2015) Maureen Cetera et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching

(2015) Yaopan Mao et al.   DEVELOPMENT

StromalFat4acts non-autonomously withDchs1/2to restrict the nephron progenitor pool

(2015) Mazdak Bagherie-Lachidan et al.   DEVELOPMENT

Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis

(2015) Nanbing Li-Villarreal et al.   DEVELOPMENT

The Drosophila planar polarity gene multiple wing hairs directly regulates the actin cytoskeleton

(2015) Q. Lu et al.   DEVELOPMENT

Clustering and Negative Feedback by Endocytosis in Planar Cell Polarity Signaling Is Modulated by Ubiquitinylation of Prickle

(2015) Bomsoo Cho et al.   PLoS Genetics

Coordination of planar cell polarity pathways through Spiny-legs

(2015) Abhijit A Ambegaonkar et al.   eLife

Cellular interpretation of the long-range gradient of Four-jointed activity in the Drosophila wing

(2015) Rosalind Hale et al.   eLife

The Balance of Prickle/Spiny-Legs Isoforms Controls the Amount of Coupling between Core and Fat PCP Systems

(2014) Matthias Merkel et al.   CURRENT BIOLOGY

Regulation of Neuronal Migration by Dchs1-Fat4 Planar Cell Polarity

(2014) Sana Zakaria et al.   CURRENT BIOLOGY

Prickle/spiny-legs isoforms control the polarity of the apical microtubule network in planar cell polarity

(2014) Jessica Olofsson et al.   DEVELOPMENT

prickle modulates microtubule polarity and axonal transport to ameliorate seizures in flies

(2014) S. N. Ehaideb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dachsous-Dependent Asymmetric Localization of Spiny-Legs Determines Planar Cell Polarity Orientation in Drosophila

(2014) Tomonori Ayukawa et al.   Cell Reports

Microtubules provide directional information for core PCP function

(2014) Maja Matis et al.   eLife

Regulation of long-range planar cell polarity by Fat-Dachsous signaling

(2013) P. Sharma et al.   DEVELOPMENT

Signal transduction by the Fat cytoplasmic domain

(2013) G. Pan et al.   DEVELOPMENT

Drosophila Dachsous and Fat polarize actin-based protrusions over a restricted domain of the embryonic denticle field

(2013) Kynan T. Lawlor et al.   DEVELOPMENTAL BIOLOGY

Planar Cell Polarity Protein Celsr1 Regulates Endothelial Adherens Junctions and Directed Cell Rearrangements during Valve Morphogenesis

(2013) Florence Tatin et al.   DEVELOPMENTAL CELL

Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila

(2013) Jun Wu et al.   NATURE CELL BIOLOGY

Shaping the nervous system: role of the core planar cell polarity genes

(2013) Fadel Tissir et al.   NATURE REVIEWS NEUROSCIENCE

Strabismus Promotes Recruitment and Degradation of Farnesylated Prickle in Drosophila melanogaster Planar Polarity Specification

(2013) Helen Strutt et al.   PLoS Genetics

Planar Polarity Specification through Asymmetric Subcellular Localization of Fat and Dachsous

(2012) Amy Brittle et al.   CURRENT BIOLOGY

Propagation of Dachsous-Fat Planar Cell Polarity

(2012) Abhijit A. Ambegaonkar et al.   CURRENT BIOLOGY

Establishment of Global Patterns of Planar Polarity during Growth of the Drosophila Wing Epithelium

(2012) Andreas Sagner et al.   CURRENT BIOLOGY

Regulation of cytoskeletal organization and junctional remodeling by the atypical cadherin Fat

(2012) E. Marcinkevicius et al.   DEVELOPMENT

Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity

(2012) G. Struhl et al.   DEVELOPMENT

Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous

(2012) H. Matakatsu et al.   DEVELOPMENT

Expanding the Morphogenetic Repertoire: Perspectives from the Drosophila Egg

(2012) David Bilder et al.   DEVELOPMENTAL CELL

Mechanical Control of Morphogenesis by Fat/Dachsous/Four-Jointed Planar Cell Polarity Pathway

(2012) F. Bosveld et al.   SCIENCE

Planar Cell Polarity and the Developmental Control of Cell Behavior in Vertebrate Embryos

(2011) John B. Wallingford   Annual Review of Cell and Developmental Biology

dachsous and frizzled contribute separately to planar polarity in the Drosophila ventral epidermis

(2011) S. Donoughe et al.   DEVELOPMENT

Principles of planar polarity in animal development

(2011) L. V. Goodrich et al.   DEVELOPMENT

Ral GTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation

(2011) Bomsoo Cho et al.   DEVELOPMENT

Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development

(2011) Y. Mao et al.   DEVELOPMENT

Polyglutamine Atrophin provokes neurodegeneration inDrosophilaby repressingfat

(2011) Francesco Napoletano et al.   EMBO JOURNAL

Planar polarization of the atypical myosin Dachs orients cell divisions in Drosophila

(2011) Y. Mao et al.   GENES & DEVELOPMENT

Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin–β-catenin

(2011) Ivana Mirkovic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Translating cell polarity into tissue elongation

(2011) Athea Vichas et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Two Frizzled Planar Cell Polarity Signals in the Drosophila Wing Are Differentially Organized by the Fat/Dachsous Pathway

(2011) Justin Hogan et al.   PLoS Genetics

Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium of Drosophila

(2010) Benoît Aigouy et al.   CELL

Four-Jointed Modulates Growth and Planar Polarity by Reducing the Affinity of Dachsous for Fat

(2010) Amy L. Brittle et al.   CURRENT BIOLOGY

Modulation of Fat:Dachsous Binding by the Cadherin Domain Kinase Four-Jointed

(2010) Michael A. Simon et al.   CURRENT BIOLOGY

Planar cell polarity: the orientation of larval denticles in Drosophila appears to depend on gradients of Dachsous and Fat

(2010) A. Repiso et al.   DEVELOPMENT

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

Atypical Cadherins Dachsous and Fat Control Dynamics of Noncentrosomal Microtubules in Planar Cell Polarity

(2010) Toshiyuki Harumoto et al.   DEVELOPMENTAL CELL

Cell shape and epithelial patterning in the Drosophila embryonic epidermis

(2010) Masayasu Hirano et al.   FLY

Drosophila Rab23 Is Involved in the Regulation of the Number and Planar Polarization of the Adult Cuticular Hairs

(2010) C. Pataki et al.   GENETICS

Modelling and Analysis of Planar Cell Polarity

(2009) S. Schamberg et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Oriented Cell Division as a Response to Cell Death and Cell Competition

(2009) Wei Li et al.   CURRENT BIOLOGY

Planar polarity and short-range polarization in Drosophila embryos

(2009) Claire Bertet et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Order and Stochastic Dynamics in Drosophila Planar Cell Polarity

(2009) Yoram Burak et al.   PLoS Computational Biology

Asymmetric Homotypic Interactions of the Atypical Cadherin Flamingo Mediate Intercellular Polarity Signaling

(2008) Wei-Shen Chen et al.   CELL

The DHHC Palmitoyltransferase Approximated Regulates Fat Signaling and Dachs Localization and Activity

(2008) Hitoshi Matakatsu et al.   CURRENT BIOLOGY

Planar polarity genes in the Drosophila wing regulate the localisation of the FH3-domain protein Multiple Wing Hairs to control the site of hair production

(2008) D. Strutt et al.   DEVELOPMENT

The Frizzled Planar Cell Polarity signaling pathway controls Drosophila wing topography

(2008) Kristy Doyle et al.   DEVELOPMENTAL BIOLOGY

Molecular dissection of Drosophila Prickle isoforms distinguishes their essential and overlapping roles in planar cell polarity

(2008) Yung-Yao Lin et al.   DEVELOPMENTAL BIOLOGY

The Frizzled Extracellular Domain Is a Ligand for Van Gogh/Stbm during Nonautonomous Planar Cell Polarity Signaling

(2008) Jun Wu et al.   DEVELOPMENTAL CELL

The multiple-wing-hairs Gene Encodes a Novel GBD-FH3 Domain-Containing Protein That Functions Both Prior to and After Wing Hair Initiation

(2008) J. Yan et al.   GENETICS

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease

(2008) Sakura Saburi et al.   NATURE GENETICS

Cell packing influences planar cell polarity signaling

(2008) D. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Four-jointed Is a Golgi Kinase That Phosphorylates a Subset of Cadherin Domains

(2008) H. O. Ishikawa et al.   SCIENCE

Nemo is required in a subset of photoreceptors to regulate the speed of ommatidial rotation

(2007) Ryan W. Fiehler et al.   DEVELOPMENTAL BIOLOGY