Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling

The native ORAI channel trio underlies the diversity of Ca2+ signaling events

(2020) Ryan E. Yoast et al.   Nature Communications

STIM2 targets Orai1/STIM1 to the AKAP79 signaling complex and confers coupling of Ca2+entry with NFAT1 activation

(2020) Ga-Yeon Son et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crosstalk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity

(2019) Scott M. Emrich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRAC Channels And Disease – From Human CRAC Channelopathies And Animal Models To Novel Drugs

(2019) Stefan Feske   CELL CALCIUM

Molecular basis of allosteric Orai1 channel activation by STIM1

(2019) Priscilla See‐Wai Yeung et al.   JOURNAL OF PHYSIOLOGY-LONDON

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

(2019) Xuexin Zhang et al.   Nature Communications

Store-Operated Calcium Channels: From Function to Structure and Back Again

(2019) Richard S. Lewis   Cold Spring Harbor Perspectives in Biology

The remote allosteric control of Orai channel gating

(2019) Yandong Zhou et al.   PLOS BIOLOGY

Ca2+ Signaling in Exocrine Cells

(2019) Malini Ahuja et al.   Cold Spring Harbor Perspectives in Biology

Calcium store refilling and STIM activation in STIM- and Orai-deficient cell lines

(2018) Sisi Zheng et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Cross-linking of Orai1 channels by STIM proteins

(2018) Yandong Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM2 Induces Activated Conformation of STIM1 to Control Orai1 Function in ER-PM Junctions

(2018) Krishna Prasad Subedi et al.   Cell Reports

All three IP3receptor subtypes generate Ca2+puffs, the universal building blocks of IP3-evoked Ca2+signals

(2018) Stefania Mataragka et al.   JOURNAL OF CELL SCIENCE

All three IP3 receptor isoforms generate Ca2+ puffs that display similar characteristics

(2018) Jeffrey T. Lock et al.   Science Signaling

Identification of molecular determinants that govern distinct STIM2 activation dynamics

(2018) Sisi Zheng et al.   PLOS BIOLOGY

Intracellular Ca 2+ Sensing: Its Role in Calcium Homeostasis and Signaling

(2017) Rafaela Bagur et al.   MOLECULAR CELL

On the dynamical structure of calcium oscillations

(2017) James Sneyd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease

(2016) Michael J. Berridge   PHYSIOLOGICAL REVIEWS

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+release

(2016) Kamil J. Alzayady et al.   Science Signaling

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+release

(2016) Kamil J. Alzayady et al.   Science Signaling

Store-operated calcium entry: Mechanisms and modulation

(2015) Patrick G. Hogan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels

(2015) Anshul Rana et al.   JOURNAL OF CELL BIOLOGY

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

STIM2 enhances receptor-stimulated Ca 2+ signaling by promoting recruitment of STIM1 to the endoplasmic reticulum–plasma membrane junctions

(2015) Hwei Ling Ong et al.   Science Signaling

A STIM2 splice variant negatively regulates store-operated calcium entry

(2015) Anna-Maria Miederer et al.   Nature Communications

STIM2 enhances receptor-stimulated Ca 2+ signaling by promoting recruitment of STIM1 to the endoplasmic reticulum–plasma membrane junctions

(2015) Hwei Ling Ong et al.   Science Signaling

An algorithm for automated detection, localization and measurement of local calcium signals from camera-based imaging

(2014) Kyle L. Ellefsen et al.   CELL CALCIUM

Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site

(2014) Xizhuo Wang et al.   Nature Communications

Frequency decoding of calcium oscillations

(2013) Erik Smedler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

STIM2 drives Ca2+oscillations through store-operated Ca2+entry caused by mild store depletion

(2013) Markus Thiel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mechanisms of STIM1 Activation of Store-Independent Leukotriene C4-Regulated Ca2+ Channels

(2013) X. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Dynamic Response Diversity of NFAT Isoforms in Individual Living Cells

(2012) Nissan Yissachar et al.   MOLECULAR CELL

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism

(2010) M. K. Korzeniowski et al.   Science Signaling

Calcium Oscillations

(2010) G. Dupont et al.   Cold Spring Harbor Perspectives in Biology

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

STIM1 Is a Calcium Sensor Specialized for Digital Signaling

(2009) Gary S. Bird et al.   CURRENT BIOLOGY

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

Signaling to gene expression: calcium, calcineurin and NFAT

(2008) Anjana Rao   NATURE IMMUNOLOGY