Identification of molecular determinants that govern distinct STIM2 activation dynamics

STIM1, but not STIM2, Is the Calcium Sensor Critical for Sweat Secretion

(2018) Chang-Yi Cui et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

STIM2 Induces Activated Conformation of STIM1 to Control Orai1 Function in ER-PM Junctions

(2018) Krishna Prasad Subedi et al.   Cell Reports

Coiled-Coil Formation Conveys a STIM1 Signal from ER Lumen to Cytoplasm

(2018) Nupura Hirve et al.   Cell Reports

Molecular anatomy of the early events in STIM1 activation – oligomerization or conformational change?

(2017) Marek K. Korzeniowski et al.   JOURNAL OF CELL SCIENCE

Role of STIM2 in cell function and physiopathology

(2017) Alejandro Berna-Erro et al.   JOURNAL OF PHYSIOLOGY-LONDON

Optical control of membrane tethering and interorganellar communication at nanoscales

(2017) Lian He et al.   Chemical Science

Molecular mechanisms of STIM/Orai communication

(2016) Isabella Derler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

TMCO1 Is an ER Ca 2+ Load-Activated Ca 2+ Channel

(2016) Qiao-Chu Wang et al.   CELL

The Orai1 Store-operated Calcium Channel Functions as a Hexamer

(2016) Xiangyu Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model

(2016) J. Wu et al.   JOURNAL OF NEUROSCIENCE

Molecular mechanisms underlying inhibition of STIM1-Orai1-mediated Ca2+ entry induced by 2-aminoethoxydiphenyl borate

(2016) Ming Wei et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes

(2016) Abigail G Garrity et al.   eLife

Store-operated calcium entry: Mechanisms and modulation

(2015) Patrick G. Hogan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular Biophysics of Orai Store-Operated Ca2+ Channels

(2015) Anna Amcheslavsky et al.   BIOPHYSICAL JOURNAL

STIM1L traps and gates Orai1 channels without remodeling the cortical ER

(2015) S. Sauc et al.   JOURNAL OF CELL SCIENCE

Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease

(2015) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Proteomic mapping of ER–PM junctions identifies STIMATE as a regulator of Ca2+ influx

(2015) Ji Jing et al.   NATURE CELL BIOLOGY

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

STIM2 enhances receptor-stimulated Ca 2+ signaling by promoting recruitment of STIM1 to the endoplasmic reticulum–plasma membrane junctions

(2015) Hwei Ling Ong et al.   Science Signaling

Inside-out Ca2+ signalling prompted by STIM1 conformational switch

(2015) Guolin Ma et al.   Nature Communications

A STIM2 splice variant negatively regulates store-operated calcium entry

(2015) Anna-Maria Miederer et al.   Nature Communications

STIM1 dimers undergo unimolecular coupling to activate Orai1 channels

(2015) Yandong Zhou et al.   Nature Communications

STIM2 enhances receptor-stimulated Ca 2+ signaling by promoting recruitment of STIM1 to the endoplasmic reticulum–plasma membrane junctions

(2015) Hwei Ling Ong et al.   Science Signaling

A Low Affinity GCaMP3 Variant (GCaMPer) for Imaging the Endoplasmic Reticulum Calcium Store

(2015) Mark J. Henderson et al.   PLoS One

Red fluorescent genetically encoded Ca2+indicators for use in mitochondria and endoplasmic reticulum

(2014) Jiahui Wu et al.   BIOCHEMICAL JOURNAL

Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice

(2014) Suya Sun et al.   NEURON

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site

(2014) Xizhuo Wang et al.   Nature Communications

Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA

(2014) Junji Suzuki et al.   Nature Communications

Emerging roles of store-operated Ca2+entry through STIM and ORAI proteins in immunity, hemostasis and cancer

(2013) Wolfgang Bergmeier et al.   Channels

Initial activation of STIM1, the regulator of store-operated calcium entry

(2013) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

STIM proteins: dynamic calcium signal transducers

(2012) Jonathan Soboloff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

(2011) Martin Muik et al.   EMBO JOURNAL

Design and application of a class of sensors to monitor Ca2+ dynamics in high Ca2+ concentration cellular compartments

(2011) S. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry

(2011) L. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Basic Sequence in STIM1 Promotes Ca2+Influx by Interacting with the C-Terminal Acidic Coiled Coil of Orai1

(2010) Nathaniel Calloway et al.   BIOCHEMISTRY

Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism

(2010) M. K. Korzeniowski et al.   Science Signaling

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+

(2009) Yun Huang et al.   FEBS Journal

The Short N-terminal Domains of STIM1 and STIM2 Control the Activation Kinetics of Orai1 Channels

(2009) Yandong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

STIM protein coupling in the activation of Orai channels

(2009) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry

(2009) Y. Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death

(2009) A. Berna-Erro et al.   Science Signaling

Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2

(2008) Le Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

(2008) Peter B. Stathopulos et al.   CELL

STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy

(2008) Laura Navarro-Borelly et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

(2008) Riina M. Luik et al.   NATURE

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

(2008) Masatsugu Oh-hora et al.   NATURE IMMUNOLOGY

STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation

(2007) Suhel Parvez et al.   FASEB JOURNAL