Ginseng Saponin Enriched in Rh1 and Rg2 Ameliorates Nonalcoholic Fatty Liver Disease by Inhibiting Inflammasome Activation

Proportion of NAFLD patients with normal ALT value in overall NAFLD patients: a systematic review and meta-analysis

(2020) Xuefeng Ma et al.   BMC GASTROENTEROLOGY

Role and Mechanisms of Mitophagy in Liver Diseases

(2020) Xiaowen Ma et al.   Cells

Ginsenoside Rb1 Alleviated High-Fat-Diet-Induced Hepatocytic Apoptosis via Peroxisome Proliferator-Activated Receptor γ

(2020) Bing Song et al.   Biomed Research International

Minor Ginsenoside Rg2 and Rh1 Attenuates LPS-Induced Acute Liver and Kidney Damages via Downregulating Activation of TLR4-STAT1 and Inflammatory Cytokine Production in Macrophages

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Ginsenoside Mc1 improves liver steatosis and insulin resistance by attenuating ER stress

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Autophagy in liver diseases: Time for translation?

(2019) Manon Allaire et al.   JOURNAL OF HEPATOLOGY

Combined Amelioration of Ginsenoside (Rg1, Rb1, and Rg3)-enriched Korean Red Ginseng and Probiotic Lactobacillus on Non-Alcoholic Fatty Liver Disease

(2019) Jin-Chul Kim et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Ginsenoside Rg1 Ameliorates Palmitic Acid-Induced Hepatic Steatosis and Inflammation in HepG2 Cells via the AMPK/NF-κB Pathway

(2019) Qing Xiao et al.   International Journal of Endocrinology

Fermented Korean Red Ginseng Extract Enriched in Rd and Rg3 Protects against Non-Alcoholic Fatty Liver Disease through Regulation of mTORC1

(2019) Su-Yeon Choi et al.   Nutrients

Ginsenoside Rg1 protects against non-alcoholic fatty liver disease by ameliorating lipid peroxidation, endoplasmic reticulum stress, and inflammasome activation

(2018) Yashu Xu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Rutin exhibits hepatoprotective effects in a mouse model of non-alcoholic fatty liver disease by reducing hepatic lipid levels and mitigating lipid-induced oxidative injuries

(2017) Qingsheng Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK

(2017) Qi Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Water extract of Helminthostachys zeylanica attenuates LPS-induced acute lung injury in mice by modulating NF-κB and MAPK pathways

(2017) Chian-Jiun Liou et al.   JOURNAL OF ETHNOPHARMACOLOGY

Non-alcoholic fatty liver disease: A sign of systemic disease

(2017) Isabella Reccia et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A fluorescence-based imaging method to measure in vitro and in vivo mitophagy using mt-Keima

(2017) Nuo Sun et al.   Nature Protocols

Autophagy in the liver: functions in health and disease

(2017) Takashi Ueno et al.   Nature Reviews Gastroenterology & Hepatology

Nonalcoholic Fatty Liver Disease and Insulin Resistance: New Insights and Potential New Treatments

(2017) Hironori Kitade et al.   Nutrients

Genetic factors associated with risk of metabolic syndrome and hepatocellular carcinoma

(2017) Ranran Tang et al.   Oncotarget

Mitophagy: a balance regulator of NLRP3 inflammasome activation

(2016) Min-Ji Kim et al.   BMB Reports

Innate Immunity and Inflammation in NAFLD/NASH

(2016) Marco Arrese et al.   DIGESTIVE DISEASES AND SCIENCES

Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk.) F.H. Chen: A review

(2016) Ting Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Resveratrol supplement inhibited the NF-κB inflammation pathway through activating AMPKα-SIRT1 pathway in mice with fatty liver

(2016) Yueli Tian et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Green tea extract provides extensive Nrf2-independent protection against lipid accumulation and NFκB pro- inflammatory responses during nonalcoholic steatohepatitis in mice fed a high-fat diet

(2016) Jinhui Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Salidroside protects against kainic acid-induced status epilepticus via suppressing oxidative stress

(2016) Pei-Pei Si et al.   NEUROSCIENCE LETTERS

The Role of Cholesterol in the Pathogenesis of NASH

(2016) George N. Ioannou   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Signaling via the NFκB system

(2016) Simon Mitchell et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

MicroRNA-181a suppresses parkin-mediated mitophagy and sensitizes neuroblastoma cells to mitochondrial uncoupler-induced apoptosis

(2016) Min Cheng et al.   Oncotarget

Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy

(2015) Jie Li et al.   Autophagy

Anti-inflammatory effects of ginsenoside Rg1 and its metabolites ginsenoside Rh1 and 20(S)-protopanaxatriol in mice with TNBS-induced colitis

(2015) Sang-Yun Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Bacterial recognition pathways that lead to inflammasome activation

(2015) Kelly M. Storek et al.   IMMUNOLOGICAL REVIEWS

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview

(2015) Alice S. T. Wong et al.   NATURAL PRODUCT REPORTS

Defective mitochondrial fission augments NLRP3 inflammasome activation

(2015) Sangjun Park et al.   Scientific Reports

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

(2015) Joe Dan Dunn et al.   Redox Biology

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

(2014) Nathalie Esser et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Nuclear Factor E2-related Factor-2 (Nrf2) Is Required for NLRP3 and AIM2 Inflammasome Activation

(2014) Changcheng Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Saponins in the genus Panax L. (Araliaceae): A systematic review of their chemical diversity

(2014) Wen-zhi Yang et al.   PHYTOCHEMISTRY

Functions of autophagy in normal and diseased liver

(2013) Mark J. Czaja et al.   Autophagy

Non-alcoholic fatty liver disease as an independent manifestation of the metabolic syndrome: Results of a US national survey in three ethnic groups

(2013) Mark M Smits et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

(2013) Alexander Wree et al.   Nature Reviews Gastroenterology & Hepatology

Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis

(2013) Laura J. Dixon et al.   PLoS One

The Inflammasome Puts Obesity in the Danger Zone

(2012) Rinke Stienstra et al.   Cell Metabolism

The inflammasome: A remote control for metabolic syndrome

(2012) Mohamed Lamkanfi et al.   CELL RESEARCH

Sensing of microbial molecular patterns by Toll-like receptors

(2012) Dong Hyun Song et al.   IMMUNOLOGICAL REVIEWS

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Mechanisms of mitochondria and autophagy crosstalk

(2011) Angelika S. Rambold et al.   CELL CYCLE

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet-Induced Insulin Resistance

(2011) Y. S. Lee et al.   DIABETES

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Mitochondrial Dynamics in Mammalian Health and Disease

(2009) Marc Liesa et al.   PHYSIOLOGICAL REVIEWS

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Autophagy in the liver

(2008) Xiao-Ming Yin et al.   HEPATOLOGY

Cirrhosis and liver failure in nonalcoholic fatty liver disease: Molehill or mountain?

(2008) Michael Charlton   HEPATOLOGY