Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain

The emergence of transcriptional identity in somatosensory neurons

(2020) Nikhil Sharma et al.   NATURE

Understanding the genetic basis of congenital insensitivity to pain

(2020) Ichrak Drissi et al.   BRITISH MEDICAL BULLETIN

Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons

(2020) Behrang Sharif et al.   NEURON

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus

(2019) Jessica Marcandalli et al.   CELL

Electrophysiological and transcriptomic correlates of neuropathic pain in human dorsal root ganglion neurons

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An Atlas of Vagal Sensory Neurons and Their Molecular Specialization

(2019) Jussi Kupari et al.   Cell Reports

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Hereditary Sensory and Autonomic Neuropathies: Adding More to the Classification

(2019) Coreen Schwartzlow et al.   Current Neurology and Neuroscience Reports

Resolving medulloblastoma cellular architecture by single-cell genomics

(2019) Volker Hovestadt et al.   NATURE

Joint analysis of heterogeneous single-cell RNA-seq dataset collections

(2019) Nikolas Barkas et al.   NATURE METHODS

Genome-wide association study of multisite chronic pain in UK Biobank

(2019) Keira J. A. Johnston et al.   PLoS Genetics

The Genetics of Neuropathic Pain from Model Organisms to Clinical Application

(2019) Margarita Calvo et al.   NEURON

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

(2018) Tathiane M. Malta et al.   CELL

Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals

(2018) Jonathan R. I. Coleman et al.   MOLECULAR PSYCHIATRY

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

(2018) Jeanne E. Savage et al.   NATURE GENETICS

Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways

(2018) Mats Nagel et al.   NATURE GENETICS

Genetic identification of brain cell types underlying schizophrenia

(2018) Nathan G. Skene et al.   NATURE GENETICS

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

(2018) Hilary K. Finucane et al.   NATURE GENETICS

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

(2018) Martin Häring et al.   NATURE NEUROSCIENCE

Peripheral and Central Mechanisms of Itch

(2018) Xintong Dong et al.   NEURON

Systematic review and meta-analysis of genetic risk factors for neuropathic pain

(2018) Abirami Veluchamy et al.   PAIN

Human pain genetics database

(2018) Carolina B. Meloto et al.   PAIN

Comparative transcriptome profiling of the human and mouse dorsal root ganglia

(2018) Pradipta Ray et al.   PAIN

Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor

(2018) Megan Crow et al.   Nature Communications

Enrichment of schizophrenia heritability in both neuronal and glia cell regulatory elements

(2018) Katherine E. Tansey et al.   Translational Psychiatry

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain

(2018) Pradeep Suri et al.   PLoS Genetics

The Gene Ontology Resource: 20 years and still GOing strong

(2018)   NUCLEIC ACIDS RESEARCH

Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males

(2018) Shad B. Smith et al.   PAIN

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination

(2017) Alice Arcourt et al.   NEURON

Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes

(2017) Marc Parisien et al.   Cell Reports

Phenome-wide heritability analysis of the UK Biobank

(2017) Tian Ge et al.   PLoS Genetics

Voltage-gated Na+ currents in human dorsal root ganglion neurons

(2017) Xiulin Zhang et al.   eLife

STRT-seq-2i: dual-index 5ʹ single cell and nucleus RNA-seq on an addressable microwell array

(2017) Hannah Hochgerner et al.   Scientific Reports

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells

(2016) Gioele La Manno et al.   CELL

Transcriptomic analyses of genes and tissues in inherited sensory neuropathies

(2016) Matthew R. Sapio et al.   EXPERIMENTAL NEUROLOGY

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Genetic predictors of human chronic pain conditions

(2016) Katerina Zorina-Lichtenwalter et al.   NEUROSCIENCE

Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity

(2015) Chang-Lin Li et al.   CELL RESEARCH

Human Nav1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons

(2015) Chongyang Han et al.   JOURNAL OF NEUROPHYSIOLOGY

The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4

(2015) Y. Li et al.   JOURNAL OF NEUROSCIENCE

Transcriptional regulator PRDM12 is essential for human pain perception

(2015) Ya-Chun Chen et al.   NATURE GENETICS

Gene expression analysis identifies global gene dosage sensitivity in cancer

(2015) Rudolf S N Fehrmann et al.   NATURE GENETICS

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

RNA-Seq Analysis of Human Trigeminal and Dorsal Root Ganglia with a Focus on Chemoreceptors

(2015) Caroline Flegel et al.   PLoS One

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

The phenotype of congenital insensitivity to pain due to the NaV1.9 variant p.L811P

(2014) Christopher Geoffrey Woods et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Human sensory neurons: Membrane properties and sensitization by inflammatory mediators

(2014) Steve Davidson et al.   PAIN

Shared genetic factors underlie chronic pain syndromes

(2014) Jelle Vehof et al.   PAIN

Lost but making progress--Where will new analgesic drugs come from?

(2014) D. Borsook et al.   Science Translational Medicine

UK Biobank Data: Come and Get It

(2014) N. E. Allen et al.   Science Translational Medicine

The Cellular Code for Mammalian Thermosensation

(2013) L. A. Pogorzala et al.   JOURNAL OF NEUROSCIENCE

A Sensory-Labeled Line for Cold: TRPM8-Expressing Sensory Neurons Define the Cellular Basis for Cold, Cold Pain, and Cooling-Mediated Analgesia

(2013) W. M. Knowlton et al.   JOURNAL OF NEUROSCIENCE

A de novo gain-of-function mutation in SCN11A causes loss of pain perception

(2013) Enrico Leipold et al.   NATURE GENETICS

Smart-seq2 for sensitive full-length transcriptome profiling in single cells

(2013) Simone Picelli et al.   NATURE METHODS

The phenotypic and genetic signatures of common musculoskeletal pain conditions

(2013) Luda Diatchenko et al.   Nature Reviews Rheumatology

The Sensory Neurons of Touch

(2013) Victoria E. Abraira et al.   NEURON

Peptidergic CGRPα Primary Sensory Neurons Encode Heat and Itch and Tonically Suppress Sensitivity to Cold

(2013) Eric S. McCoy et al.   NEURON

Mechanisms of Itch Evoked by  -Alanine

(2012) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

A subpopulation of nociceptors specifically linked to itch

(2012) Liang Han et al.   NATURE NEUROSCIENCE

Population coding of somatic sensations

(2012) Qiufu Ma   Neuroscience Bulletin

Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch

(2011) Hind Abdo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Transcription Factor Short Stature Homeobox 2 Is Required for Proper Development of Tropomyosin-Related Kinase B-Expressing Mechanosensory Neurons

(2011) A. Scott et al.   JOURNAL OF NEUROSCIENCE

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Overcoming obstacles to developing new analgesics

(2010) Clifford J Woolf   NATURE MEDICINE

Animal models of pain: progress and challenges

(2009) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

(2009) D. J. Cavanaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA