Transcriptional regulator PRDM12 is essential for human pain perception

SNPdryad: predicting deleterious non-synonymous human SNPs using only orthologous protein sequences

(2014) Ka-Chun Wong et al.   BIOINFORMATICS

prdm12b specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements

(2014) Denise A. Zannino et al.   DEVELOPMENTAL BIOLOGY

Painful and painless channelopathies

(2014) David L H Bennett et al.   LANCET NEUROLOGY

Characterizing Human Stem Cell–derived Sensory Neurons at the Single-cell Level Reveals Their Ion Channel Expression and Utility in Pain Research

(2014) Gareth T Young et al.   MOLECULAR THERAPY

MutationTaster2: mutation prediction for the deep-sequencing age

(2014) Jana Marie Schwarz et al.   NATURE METHODS

Prdm12 Is Induced by Retinoic Acid and Exhibits Anti-proliferative Properties through the Cell Cycle Modulation of P19 Embryonic Carcinoma Cells

(2013) Chia-Ming Yang et al.   CELL STRUCTURE AND FUNCTION

Disruption of nodal architecture in skin biopsies of patients with demyelinating neuropathies

(2013) Kathrin Doppler et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

A de novo gain-of-function mutation in SCN11A causes loss of pain perception

(2013) Enrico Leipold et al.   NATURE GENETICS

Genes and epigenetic processes as prospective pain targets

(2013) Megan Crow et al.   Genome Medicine

Mechanistic Insight into the Pathology of Polyalanine Expansion Disorders Revealed by a Mouse Model for X Linked Hypopituitarism

(2013) James Hughes et al.   PLoS Genetics

Human Mendelian pain disorders: a key to discovery and validation of novel analgesics

(2012) YP Goldberg et al.   CLINICAL GENETICS

The Prdm family: expanding roles in stem cells and development

(2012) T. Hohenauer et al.   DEVELOPMENT

Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development

(2012) S.-L. Tan et al.   DEVELOPMENT

Transcription Factor Positive Regulatory Domain 4 (PRDM4) Recruits Protein Arginine Methyltransferase 5 (PRMT5) to Mediate Histone Arginine Methylation and Control Neural Stem Cell Proliferation and Differentiation

(2012) Alexandra Chittka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

(2012) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Epigenetic mechanisms in neurological disease

(2012) Mira Jakovcevski et al.   NATURE MEDICINE

Anti-NGF painkillers back on track?

(2012) David Holmes   NATURE REVIEWS DRUG DISCOVERY

Chronic Pain: Emerging Evidence for the Involvement of Epigenetics

(2012) Franziska Denk et al.   NEURON

Predicting the Functional Effect of Amino Acid Substitutions and Indels

(2012) Yongwook Choi et al.   PLoS One

Epigenetic control on cell fate choice in neural stem cells

(2012) Xiao-Ling Hu et al.   Protein & Cell

SH3TC2, a protein mutant in Charcot–Marie–Tooth neuropathy, links peripheral nerve myelination to endosomal recycling

(2011) Claudia Stendel et al.   BRAIN

Epigenetic regulation of sensory neurogenesis in the dorsal root ganglion cell line ND7 by folic acid

(2011) Vanda Boshnjaku et al.   Epigenetics

Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss

(2011) Christopher J Klein et al.   NATURE GENETICS

Chromatin modification of Notch targets in olfactory receptor neuron diversification

(2011) Keita Endo et al.   NATURE NEUROSCIENCE

Nociceptors: the sensors of the pain pathway

(2010) Adrienne E. Dubin et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy

(2010) O. P. Carvalho et al.   JOURNAL OF MEDICAL GENETICS

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Transcriptional control of Rohon-Beard sensory neuron development at the neural plate border

(2009) Christy Cortez Rossi et al.   DEVELOPMENTAL DYNAMICS

The neural crest and neural crest cells: discovery and significance for theories of embryonic organization

(2009) Brian K. Hall   JOURNAL OF BIOSCIENCES

SH3TC2/KIAA1985 protein is required for proper myelination and the integrity of the node of Ranvier in the peripheral nervous system

(2009) E. Arnaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular landscape of ASPM mutations in primary microcephaly

(2008) A K Nicholas et al.   JOURNAL OF MEDICAL GENETICS

Prdm Proto-Oncogene Transcription Factor Family Expression and Interaction with the Notch-Hes Pathway in Mouse Neurogenesis

(2008) Emi Kinameri et al.   PLoS One