Biological Evaluation of 5′-(N-Ethylcarboxamido)adenosine Analogues as Grp94-Selective Inhibitors

Overexpression of molecule GRP94 favors tumor progression in lung adenocarcinoma by interaction with regulatory T cells

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Multiple adenosine receptor subtypes stimulate wound healing in human EA.hy926 endothelial cells

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NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90

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Involvement of adenosine A2B receptor in radiation-induced translocation of epidermal growth factor receptor and DNA damage response leading to radioresistance in human lung cancer cells

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Glucose-regulated protein of 94 kDa contributes to the development of an aggressive phenotype in breast cancer cells

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Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding

(2018) Nanette L. S. Que et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor

(2018) Anuj Khandelwal et al.   Nature Communications

Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors

(2017) Hye-Kyung Park et al.   JOURNAL OF MEDICINAL CHEMISTRY

Current Understanding of HSP90 as a Novel Therapeutic Target: An Emerging Approach for the Treatment of Cancer

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Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold

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5′-N -ethylcarboxamidoadenosine is not a paralog-specific Hsp90 inhibitor

(2016) Shanshan Liu et al.   PROTEIN SCIENCE

Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma

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Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

(2013) Pallav D Patel et al.   Nature Chemical Biology

Structure, Function and Regulation of the Hsp90 Machinery

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Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

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The Therapeutic Target Hsp90 and Cancer Hallmarks

(2012) Yoshihiko Miyata et al.   CURRENT PHARMACEUTICAL DESIGN

Glucose-regulated Protein 94 Triage of Mutant Myocilin through Endoplasmic Reticulum-associated Degradation Subverts a More Efficient Autophagic Clearance Mechanism

(2012) Amirthaa Suntharalingam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Molecular Chaperone gp96/GRP94 Interacts with Toll-like Receptors and Integrins via Its C-terminal Hydrophobic Domain

(2012) Shuang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hallmarks of Cancer: The Next Generation

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