(p)ppGpp/GTP and Malonyl-CoA Modulate Staphylococcus aureus Adaptation to FASII Antibiotics and Provide a Basis for Synergistic Bi-Therapy

Revisiting the coupling of fatty acid to phospholipid synthesis in bacteria with FapR regulation

(2020) Federico Machinandiarena et al.   MOLECULAR MICROBIOLOGY

Liposomal mupirocin holds promise for systemic treatment of invasive Staphylococcus aureus infections

(2019) Oliver Goldmann et al.   JOURNAL OF CONTROLLED RELEASE

Permissive Fatty Acid Incorporation Promotes Staphylococcal Adaptation to FASII Antibiotics in Host Environments

(2019) Gérald Kénanian et al.   Cell Reports

Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen

(2018) Gleb Pishchany et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and application of genetically-encoded malonyl-CoA biosensors for metabolic engineering of microbial cell factories

(2017) Abayomi Oluwanbe Johnson et al.   METABOLIC ENGINEERING

(p)ppGpp and the bacterial cell cycle

(2016) Aanisa Nazir et al.   JOURNAL OF BIOSCIENCES

The stringent response plays a key role inBacillus subtilissurvival of fatty acid starvation

(2016) André A. Pulschen et al.   MOLECULAR MICROBIOLOGY

Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials

(2016) Claire Morvan et al.   Nature Communications

A Defensin from the Model Beetle Tribolium castaneum Acts Synergistically with Telavancin and Daptomycin against Multidrug Resistant Staphylococcus aureus

(2015) Rajmohan Rajamuthiah et al.   PLoS One

Fatty acid synthesis in Escherichia coli and its applications towards the production of fatty acid based biofuels

(2014) Helge Janßen et al.   Biotechnology for Biofuels

Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus

(2014) J. B. Parsons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Staphylococcus aureus Fatty Acid Auxotrophs Do Not Proliferate in Mice

(2013) Joshua B. Parsons et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Intersection of the stringent response and the CodY regulon in low GC Gram-positive bacteria

(2013) Tobias Geiger et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Two Small (p)ppGpp Synthases in Staphylococcus aureus Mediate Tolerance against Cell Envelope Stress Conditions

(2013) T. Geiger et al.   JOURNAL OF BACTERIOLOGY

Transcription of the Escherichia coli Fatty Acid Synthesis Operon fabHDG Is Directly Activated by FadR and Inhibited by ppGpp

(2013) L. My et al.   JOURNAL OF BACTERIOLOGY

Pharmacokinetics, pharmacodynamics and efficacy of novel FabI inhibitor AFN-1252 against MSSA and MRSA in the murine thigh infection model

(2013) Mary A Banevicius et al.   JOURNAL OF CHEMOTHERAPY

Structural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus aureus

(2013) Daniela Albanesi et al.   PLoS Pathogens

A Genetically Encoded Metabolite Sensor for Malonyl-CoA

(2012) Jessica M. Ellis et al.   CHEMISTRY & BIOLOGY

Environmental DNA-Encoded Antibiotics Fasamycins A and B Inhibit FabF in Type II Fatty Acid Biosynthesis

(2012) Zhiyang Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rv3080c regulates the rate of inhibition of mycobacteria by isoniazid through FabD

(2012) Ruma Kumari et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Direct Regulation of GTP Homeostasis by (p)ppGpp: A Critical Component of Viability and Stress Resistance

(2012) Allison Kriel et al.   MOLECULAR CELL

The Stringent Response of Staphylococcus aureus and Its Impact on Survival after Phagocytosis through the Induction of Intracellular PSMs Expression

(2012) Tobias Geiger et al.   PLoS Pathogens

Global Analysis of the Staphylococcus aureus Response to Mupirocin

(2011) Swantje Reiß et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The MUT056399 Inhibitor of FabI Is a New Antistaphylococcal Compound

(2011) S. Escaich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of Intracellular Heme-binding Protein HrtR, Which Controls Heme Efflux by the Conserved HrtB-HrtA Transporter inLactococcus lactis

(2011) Delphine Lechardeur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors

(2011) J. B. Parsons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repair of Global Regulators in Staphylococcus aureus 8325 and Comparative Analysis with Other Clinical Isolates

(2010) S. Herbert et al.   INFECTION AND IMMUNITY

Two Novel Point Mutations in Clinical Staphylococcus aureus Reduce Linezolid Susceptibility and Switch on the Stringent Response to Promote Persistent Infection

(2010) Wei Gao et al.   PLoS Pathogens

Molecular Dissection of the secA2 Locus of Group B Streptococcus Reveals that Glycosylation of the Srr1 LPXTG Protein Is Required for Full Virulence

(2009) M.-Y. Mistou et al.   JOURNAL OF BACTERIOLOGY

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

(2009) Sophie Brinster et al.   NATURE

Inhibitors of FabI, an Enzyme Drug Target in the Bacterial Fatty Acid Biosynthesis Pathway

(2008) Hao Lu et al.   ACCOUNTS OF CHEMICAL RESEARCH

(p)ppGpp: Still Magical?

(2008) Katarzyna Potrykus et al.   Annual Review of Microbiology

Application of Functional Genomics to Pathway Optimization for Increased Isoprenoid Production

(2008) L. Kizer et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Selective Fluorescent Chemosensor for the Bacterial Alarmone (p)ppGpp

(2008) Hyun-Woo Rhee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY