Peroxisomes as Cellular Adaptors to Metabolic and Environmental Stress

Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy

(2020) Doo Sin Jo et al.   Autophagy

Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5

(2020) Jinuk Kong et al.   Nature Communications

Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway

(2020) Michael M. Dubreuil et al.   Cell Reports

Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism

(2020) Isha H. Jain et al.   CELL

Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation

(2020) Anyuan He et al.   MOLECULAR CELL

Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms

(2020) Hyung-lok Chung et al.   NEURON

TheTMEM189gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens

(2020) Ernst R. Werner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

(2020) Yilong Zou et al.   NATURE

The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation

(2020) Kanji Okumoto et al.   eLife

Distinct Functions of Acyl/Alkyl Dihydroxyacetonephosphate Reductase in Peroxisomes and Endoplasmic Reticulum

(2020) Masanori Honsho et al.   Frontiers in Cell and Developmental Biology

CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4

(2019) Xiphias Ge Zhu et al.   MOLECULAR CELL

Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage

(2019) Jean Defourny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute and chronic hypoxia differentially predispose lungs for metastases

(2019) Moritz Reiterer et al.   Scientific Reports

A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis

(2019) Aránzazu Gallego-García et al.   SCIENCE

Redox Signaling from and to Peroxisomes: Progress, Challenges, and Prospects

(2018) Marc Fransen et al.   ANTIOXIDANTS & REDOX SIGNALING

Catalase inhibition induces pexophagy through ROS accumulation

(2018) Joon No Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer

(2018) Xiu‐Fei Chen et al.   EMBO REPORTS

Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol

(2018) Ana G. Pedrosa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Common and Distinct Features of Brown and Beige Adipocytes

(2018) Kenji Ikeda et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication

(2018) Pierre M. Jean Beltran et al.   Cell Host & Microbe

Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

(2018) Sung Min Son et al.   Cell Metabolism

Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation

(2018) Daniel Ackerman et al.   Cell Reports

Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission

(2018) Hongsuk Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Peroxisome-Mediated Metabolism Is Required for Immune Response to Microbial Infection

(2017) Francesca Di Cara et al.   IMMUNITY

The VDAC2–BAK axis regulates peroxisomal membrane permeability

(2017) Ken-ichiro Hosoi et al.   JOURNAL OF CELL BIOLOGY

VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis

(2017) Rong Hua et al.   JOURNAL OF CELL BIOLOGY

Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes

(2017) Ayumu Sugiura et al.   NATURE

Cytosolic lipolysis and lipophagy: two sides of the same coin

(2017) Rudolf Zechner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Peroxisomal Dysfunction in Age-Related Diseases

(2017) Cynthia M. Cipolla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Structural and functional roles of ether lipids

(2017) John M. Dean et al.   Protein & Cell

Phagocytosis: An Immunobiologic Process

(2016) Siamon Gordon   IMMUNITY

C13orf31 (FAMIN) is a central regulator of immunometabolic function

(2016) M Zaeem Cader et al.   NATURE IMMUNOLOGY

Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer

(2016) S Chouaib et al.   ONCOGENE

Mechanisms of ATM Activation

(2015) Tanya T. Paull   Annual Review of Biochemistry

Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts

(2015) Bei-Bei Chu et al.   CELL

Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes

(2015) Sedigheh Delmaghani et al.   CELL

FAT FLUX: enzymes, regulators, and pathophysiology of intracellular lipolysis

(2015) R. Zechner   EMBO Molecular Medicine

Flavivirus Infection Impairs Peroxisome Biogenesis and Early Antiviral Signaling

(2015) Jaehwan You et al.   JOURNAL OF VIROLOGY

ATM functions at the peroxisome to induce pexophagy in response to ROS

(2015) Jiangwei Zhang et al.   NATURE CELL BIOLOGY

Zellweger spectrum disorders: clinical overview and management approach

(2015) Femke C. C. Klouwer et al.   Orphanet Journal of Rare Diseases

Hif-2α Promotes Degradation of Mammalian Peroxisomes by Selective Autophagy

(2014) Katharina M. Walter et al.   Cell Metabolism

Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling

(2014) Irfan J. Lodhi et al.   Cell Metabolism

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury

(2014) Pinelopi P. Kapitsinou et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

Antiviral innate immunity and stress granule responses

(2014) Koji Onomoto et al.   TRENDS IN IMMUNOLOGY

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PEX5, the Shuttling Import Receptor for Peroxisomal Matrix Proteins, Is a Redox-Sensitive Protein

(2013) Oksana Apanasets et al.   TRAFFIC

Genetics and molecular basis of human peroxisome biogenesis disorders

(2012) Hans R. Waterham et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Biochemically Distinct Vesicles from the Endoplasmic Reticulum Fuse to Form Peroxisomes

(2012) Adabella van der Zand et al.   CELL

Inhibiting Adipose Tissue Lipogenesis Reprograms Thermogenesis and PPARγ Activation to Decrease Diet-Induced Obesity

(2012) Irfan J. Lodhi et al.   Cell Metabolism

The RING-type ubiquitin ligases Pex2p, Pex10p and Pex12p form a heteromeric complex that displays enhanced activity in an ubiquitin conjugating enzyme-selective manner

(2012) Fouzi El Magraoui et al.   FEBS Journal

Transfer of metabolites across the peroxisomal membrane

(2011) Vasily D. Antonenkov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Interferon-stimulated genes and their antiviral effector functions

(2011) John W Schoggins et al.   Current Opinion in Virology

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms

(2010) Nobuko Matsushita et al.   GENES TO CELLS

The Kennedy pathway-De novo synthesis of phosphatidylethanolamine and phosphatidylcholine

(2010) Federica Gibellini et al.   IUBMB LIFE

Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism

(2010) Paul P. Van Veldhoven   JOURNAL OF LIPID RESEARCH

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

The peroxisomal importomer constitutes a large and highly dynamic pore

(2010) Michael Meinecke et al.   NATURE CELL BIOLOGY

A combination antioxidant therapy prevents age-related hearing loss in C57BL/6 mice

(2010) Selena E. Heman Ackah et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Transcriptional coactivator PGC-1  promotes peroxisomal remodeling and biogenesis

(2010) A. Bagattin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum

(2010) S. K. Lam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pex2 and Pex12 Function as Protein-Ubiquitin Ligases in Peroxisomal Protein Import

(2009) H. W. Platta et al.   MOLECULAR AND CELLULAR BIOLOGY

Stress and disorders of the stress system

(2009) George P. Chrousos   Nature Reviews Endocrinology

Peroxisome Dynamics in Cultured Mammalian Cells

(2009) Sofie J. Huybrechts et al.   TRAFFIC

Sequential changes in the expression of genes involved in lipid metabolism in adipose tissue and liver in response to fasting

(2008) M. Palou et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY