T cell circuits that sense antigen density with an ultrasensitive threshold

Human chimeric antigen receptor macrophages for cancer immunotherapy

(2020) Michael Klichinsky et al.   NATURE BIOTECHNOLOGY

Cascaded amplifying circuits enable ultrasensitive cellular sensors for toxic metals

(2019) Xinyi Wan et al.   Nature Chemical Biology

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

CAR-T cells: the long and winding road to solid tumors

(2018) Maria Michela D’Aloia et al.   Cell Death & Disease

TumGrowth: An open-access web tool for the statistical analysis of tumor growth curves

(2018) David P. Enot et al.   OncoImmunology

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

(2018) Stephen J. Schuster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric antigen receptor T-cell therapies for lymphoma

(2017) Jennifer N. Brudno et al.   Nature Reviews Clinical Oncology

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

(2017) Sattva S. Neelapu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits

(2016) Kole T. Roybal et al.   CELL

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors

(2016) Kole T. Roybal et al.   CELL

Synthetic biology approaches to engineer T cells

(2015) Chia-Yung Wu et al.   CURRENT OPINION IN IMMUNOLOGY

Stability engineering of anti-EGFR scFv antibodies by rational design of a lambda-to-kappa swap of the VLframework using a structure-guided approach

(2015) Andreas Lehmann et al.   mAbs

CAR T-cell immunotherapy: The path from the by-road to the freeway?

(2015) Lynsey M. Whilding et al.   Molecular Oncology

A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity

(2015) Alec E. Cerchiari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrasensitivity part III: cascades, bistable switches, and oscillators

(2014) James E. Ferrell et al.   TRENDS IN BIOCHEMICAL SCIENCES

Input-output relations in biological systems: measurement, information and the Hill equation

(2013) Steven A Frank   Biology Direct

Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation and Management of On-target Toxicity

(2013) Cor HJ Lamers et al.   MOLECULAR THERAPY

Ultrasensitive response motifs: basic amplifiers in molecular signalling networks

(2013) Q. Zhang et al.   Open Biology

A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth

(2011) Rob C. Roovers et al.   INTERNATIONAL JOURNAL OF CANCER

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

(2010) Maria R Parkhurst et al.   MOLECULAR THERAPY

Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments

(2010) D. Busse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab

(2008) M Pickl et al.   ONCOGENE