Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation

Global Regulation of the Histone Mark H3K36me2 Underlies Epithelial Plasticity and Metastatic Progression

(2020) Salina Yuan et al.   Cancer Discovery

Epigenomic reordering induced by Polycomb loss drives oncogenesis but leads to therapeutic vulnerabilities in malignant peripheral nerve sheath tumors

(2019) John B Wojcik et al.   CANCER RESEARCH

Histone H3 Mutations: An Updated View of Their Role in Chromatin Deregulation and Cancer

(2019) Brandon R. Lowe et al.   Cancers

Understanding histone H3 lysine 36 methylation and its deregulation in disease

(2019) Jie Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

(2019) Brian Krug et al.   CANCER CELL

The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

(2019) Daniel N. Weinberg et al.   NATURE

Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo

(2019) Justin Brumbaugh et al.   NATURE CELL BIOLOGY

Interferon target-gene expression and epigenomic signatures in health and disease

(2019) Franck J. Barrat et al.   NATURE IMMUNOLOGY

NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains

(2019) Priscillia Lhoumaud et al.   Nature Communications

DNMT3A reads and connects histone H3K36me2 to DNA methylation

(2019) Wenqi Xu et al.   Protein & Cell

Epigenetic therapy: azacytidine and decitabine in acute myeloid leukemia

(2018) Stephan R. Bohl et al.   Expert Review of Hematology

Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function

(2018) Lenan Zhuang et al.   Nature Communications

Dual inhibition of DNA and histone methyltransferases increases viral mimicry in ovarian cancer cells

(2018) Minmin Liu et al.   CANCER RESEARCH

Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers

(2018) Brianna J. Klein et al.   Epigenetics

Characterization of H3.3K36M as a tool to study H3K36 methylation in cancer cells

(2017) Saumya M. Sankaran et al.   Epigenetics

Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas

(2017) Simon Papillon-Cavanagh et al.   NATURE GENETICS

H3.1 K36M mutation in a congenital-onset soft tissue neoplasm

(2017) Kristin D. Kernohan et al.   PEDIATRIC BLOOD & CANCER

Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden

(2017) Meredith L. Stone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation

(2017) Yinglu Zhang et al.   Scientific Reports

EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma

(2016) Junli Yan et al.   BLOOD

Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase

(2016) Shuang Yang et al.   GENES & DEVELOPMENT

STAT3 signaling drives EZH2 transcriptional activation and mediates poor prognosis in gastric cancer

(2016) Yuan-Ming Pan et al.   Molecular Cancer

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

(2016) C. Lu et al.   SCIENCE

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas

(2016) D. Fang et al.   SCIENCE

Oncogenic Mechanisms of Histone H3 Mutations

(2016) Daniel N. Weinberg et al.   Cold Spring Harbor Perspectives in Medicine

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation

(2015) Sophia X. Pfister et al.   CANCER CELL

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

(2015) David Roulois et al.   CELL

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

(2013) Sam Behjati et al.   NATURE GENETICS

High-Dose Cytarabine (HD araC) in the Treatment of Leukemias: a Review

(2013) Nicholas D. Reese et al.   Current Hematologic Malignancy Reports

Negative Regulation of Type I IFN Expression by OASL1 Permits Chronic Viral Infection and CD8+ T-Cell Exhaustion

(2013) Myeong Sup Lee et al.   PLoS Pathogens

Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes

(2013) James P Reddington et al.   GENOME BIOLOGY

Crystal Structure of the Human Histone Methyltransferase ASH1L Catalytic Domain and Its Implications for the Regulatory Mechanism

(2011) Sojin An et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation

(2011) Wen Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming

(2011) Alex J. Kuo et al.   MOLECULAR CELL

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

(2011) Frank W. Schmitges et al.   MOLECULAR CELL

Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma

(2010) Gerben Duns et al.   CANCER RESEARCH