Article
Biotechnology & Applied Microbiology
Cees Haringa
Summary: This study explores the use of Euler-Lagrange CFD simulations and Lattice-Boltzmann large-eddy simulations (LB-LES) to analyze environmental gradients and the performance of the biotic phase in bioreactors. By verifying the hydrodynamic characteristics of the simulations, the results indicate that the LB-LES method can accurately simulate dynamic flowfields with significantly reduced computation times.
ENGINEERING IN LIFE SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Cees Haringa, Wenjun Tang, Henk J. Noorman
Summary: In this study, a Lagrangian reaction model was implemented for modeling the gradients in bioreactors. This approach takes into account the changes in cell populations and their response to the heterogeneous environment, resulting in better performance compared to traditional methods.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Engineering, Chemical
Peng Wei, Cees Haringa, Luis M. Portela, Henk J. Noorman
Summary: This study investigates the metabolic impacts of glucose and oxygen concentration gradients on penicillin production in an industrial-scale fermentor using computational fluid dynamics-cellular reaction dynamics approach. Oxygen coupling significantly influences glucose uptake and penicillin productivity. The study identifies six metabolic regimes and reveals rapid dynamics in glucose and dissolved oxygen uptake by microorganisms from a cellular perspective. The results are sensitive to oxygen-related model parameters, highlighting the need for accurate understanding of multiphase hydrodynamics and metabolic processes. Hypothetical scenarios with stronger glucose-oxygen limitations than tested experimentally were also explored. A precision scale-down simulator, based on lifeline data, was designed to mimic the rapid dynamics of large-scale fermentation processes, highlighting the operational dynamics, system complexity, and implementation difficulty. These insights may inspire further research on alternative scale-down configurations better suited for rapid dynamics of large-scale fermentation processes.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Lars Puiman, Eduardo Almeida Benalcazar, Cristian Picioreanu, Henk J. Noorman, Cees Haringa
Summary: In large-scale syngas fermentation, strong gradients in dissolved gas concentrations due to varying mass transfer and convection rates are analyzed in an industrial-scale external-loop gas-lift reactor (EL-GLR). Micro-organisms are likely to experience oscillations in dissolved gas concentrations with one order of magnitude. A scale-down simulator is developed to replicate industrial-scale environmental fluctuations at bench scale and can be used to validate results and obtain data for parametrizing metabolic models.
BIOENGINEERING-BASEL
(2023)
Article
Computer Science, Interdisciplinary Applications
Maria Gracka, Rui Lima, Joao M. Miranda, Sebastian Student, Bartlomiej Melka, Ziemowit Ostrowski
Summary: This study aims to develop a numerical model capable of reproducing the behavior of multiphase flow in a microchannel obtained under laboratory conditions and compare two multiphase modelling techniques. The results show reasonable agreement between experiments and simulations, indicating the potential of the developed model to expedite the microchannel design process.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Engineering, Chemical
Zhengzong Huang, Hongjie Yan, Liu Liu, Hao Gong, Ping Zhou
Summary: The Euler-Lagrange approach was used to simulate the gas-liquid reaction system in a rectangular bubble column, showing satisfactory agreement with experimental results. The study focused on the chemisorption process of CO2 in aqueous NaOH, achieving higher accuracy compared to existing literature. Additional improvements included consideration of auto-dissociation of water and accurate estimation of the mean Sauter diameter distribution curve.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Engineering, Chemical
Pedram Pakseresht, Yuan Yao, Yi Fan, Jorg Theuerkauf, Jesse Capecelatro
Summary: In this paper, the Energy Minimization Multi-Scale (EMMS) model used in simulations of circulating fluidized bed (CFB) reactors is critically reviewed and evaluated. By leveraging highly resolved Euler-Lagrange simulations, the discrepancies between the EMMS model and the actual system behavior are identified. Recommendations for improving the standard EMMS model are proposed based on the observed variations.
Article
Engineering, Marine
Qin Liu, Zhe Wang, Ning Zhang, Hongyu Zhao, Lei Liu, Kunpeng Huang, Xuguang Chen
Summary: The CFD-DEM method was applied to study local scour and proved to be effective in investigating the phenomenon around pile foundations. Local scour is influenced by various factors, not just flow velocity and drag force.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Thermodynamics
Pavel Krysa, Miroslav Soos
Summary: This study used computational fluid dynamics (CFD) to predict the breakage and coalescence of bubbles in gas-liquid systems and to predict the bubble size distribution (BSD). The CFD model was validated by comparing the simulation results with experimental data, and a characterization analysis of the system was performed.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2022)
Article
Engineering, Environmental
Abhijeet H. Thaker, Ketan R. Madane, Vivek V. Ranade
Summary: This study provides data and correlations on the influence of viscosity and device scale on cavitation inception and pressure drop in high viscosity systems. It also investigates the key flow characteristics of vortex based cavitation devices. The results show that pressure drop and cavitation inception increase with viscosity.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Computer Science, Interdisciplinary Applications
Davide Dapelo, Adrian Kummerlaender, Mathias. J. J. Krause, John Bridgeman
Summary: For the first time, an Euler-Lagrange multicomponent, non-Newtonian Lattice-Boltzmann method is used to model a full-scale gas-mixed anaerobic digester for wastewater treatment. Rheology is represented by a power-law model and turbulence is simulated using a Smagorinsky Large Eddy Simulation model. With the help of flow analysis and viscosity patterns, the hydrodynamics of the digester is studied. The findings demonstrate significant improvements in computational efficiency and spatial resolution compared to previous methods, making the Large Eddy Simulation method a feasible option for industries and consultancies.
ENGINEERING WITH COMPUTERS
(2023)
Article
Engineering, Chemical
Chih-Chia Huang, Jeroen A. van Oijen, Niels G. Deen, Yali Tang
Summary: In Euler-Lagrange models, the information exchange in particulate systems is often smoothed from particles' location to nearby computational cells. However, the current constant diffusivity approach fails to consider the variation in particle sizes in polydisperse systems. This paper proposes a particle-size dependent smoothing scheme called non-constant diffusivity approach.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Engineering, Chemical
Yannic Mast, Ralf Takors
Summary: An experimental data driven model for bubble breakage prediction in gas-liquid multiphase reactors is developed, fulfilling the requirements of the Euler-Lagrangian (EL) framework. The model uses the critical Weber number (Wecrit) as the breakage criterion, combined with the minimum time between breakage events. By minimizing the difference between simulated and measured bubble sizes, optimum Wecrit values are obtained. The model successfully predicts the impact of altered fluid properties without additional calibration.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Lars Puiman, Britt Abrahamson, Rob G. J. M. van der Lans, Cees Haringa, Henk J. Noorman, Cristian Picioreanu
Summary: The mass transfer limitations in syngas fermentation processes can be alleviated by using large-scale external-loop gas-lift reactors, which enable high mass transfer performance. A CFD model was developed and validated to provide insights on the hydrodynamics and mass transfer in these reactors. The results showed that the ethanol produced in the process could increase gas hold-up and decrease bubble diameter, leading to high mass transfer efficiency.
CHEMICAL ENGINEERING SCIENCE
(2022)
Article
Engineering, Aerospace
Babak Salamat, Gerhard Elsbacher
Summary: This article proposes an energy-efficient control method for underactuated robots, achieving optimal control through a centralized stochastic approach. The authors first present a generalized coordinate transformation for underactuated robots, considering their physical properties. Secondly, they propose an optimal control mechanism with the objective of energy efficiency, and demonstrate the feasibility of their approach through robot simulations.