Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

(2020) Alexandr A. Kapralov et al.   Nature Chemical Biology

PLA2G6 guards placental trophoblasts against ferroptotic injury

(2020) Ofer Beharier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Phenotyping of Familial Parkinson’s Disease with Human Induced Pluripotent Stem Cells: A Proof-of-Concept Study

(2019) Ourania Zygogianni et al.   NEUROCHEMICAL RESEARCH

Parkinson’s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling

(2019) Akio Mori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Selectivity of phospholipid hydrolysis by phospholipase A 2 enzymes in activated cells leading to polyunsaturated fatty acid mobilization

(2018) Alma M. Astudillo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

A new perspective on lipid research in age-related macular degeneration

(2018) Elisabeth M. van Leeuwen et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization

(2018) Konstantin R. Malley et al.   Nature Communications

Lipid metabolism alterations in the neuronal response to A53T α-synuclein and Fe-induced injury

(2018) Sofía Sánchez Campos et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?

(2018) D.A. Stoyanovsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE

(2018) Tamil S. Anthonymuthu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PLA2G6-Associated Neurodegeneration (PLAN): Review of Clinical Phenotypes and Genotypes

(2018) Yu-pei Guo et al.   Frontiers in Neurology

The phospholipase iPLA2γ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling

(2017) Gao-Yuan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On the Calculation of Acyl Chain Order Parameters from Lipid Simulations

(2017) Thomas J. Piggot et al.   Journal of Chemical Theory and Computation

Ferroptosis and cell death mechanisms in Parkinson's disease

(2017) Stephanie J. Guiney et al.   NEUROCHEMISTRY INTERNATIONAL

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease

(2016) Qingde Zhou et al.   Nature Communications

Loss ofPLA2G6leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction

(2015) Kerri J. Kinghorn et al.   BRAIN

Molecular speciation and dynamics of oxidized triacylglycerols in lipid droplets: Mass spectrometry and coarse-grained simulations

(2014) Dariush Mohammadyani et al.   FREE RADICAL BIOLOGY AND MEDICINE

Group VIA Phospholipase A2Mitigates Palmitate-induced β-Cell Mitochondrial Injury and Apoptosis

(2014) Haowei Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Differential participation of phospholipase A2 isoforms during iron-induced retinal toxicity. Implications for age-related macular degeneration

(2012) G. Rodríguez Diez et al.   NEUROCHEMISTRY INTERNATIONAL

SwissParam: A fast force field generation tool for small organic molecules

(2011) Vincent Zoete et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The PLA2G6 gene in early-onset Parkinson's disease

(2011) Kai Michael Kauther et al.   MOVEMENT DISORDERS

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Lessons from the rotenone model of Parkinson's disease

(2010) J. Timothy Greenamyre et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

CHARMM-GUI Membrane Builder for Mixed Bilayers and Its Application to Yeast Membranes

(2009) Sunhwan Jo et al.   BIOPHYSICAL JOURNAL

Characterization of PLA2G6 as a locus for dystonia-parkinsonism

(2008) Coro Paisan-Ruiz et al.   ANNALS OF NEUROLOGY

Role of Ca2+-independent phospholipase A2 in cell growth and signaling

(2008) Shelley B. Hooks et al.   BIOCHEMICAL PHARMACOLOGY