Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration
出版年份 2021 全文链接
标题
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration
作者
关键词
UPR, XBP1, ATF6, ER stress, protein aggregation, Huntington`s disease, Parkinson`s disease
出版物
MOLECULAR THERAPY
Volume -, Issue -, Pages -
出版商
Elsevier BV
发表日期
2021-02-06
DOI
10.1016/j.ymthe.2021.01.033
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mechanisms, regulation and functions of the unfolded protein response
- (2020) Claudio Hetz et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates
- (2020) Paula García-Huerta et al. ACTA NEUROPATHOLOGICA
- The UPRosome – decoding novel biological outputs of IRE1α function
- (2020) Hery Urra et al. JOURNAL OF CELL SCIENCE
- Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming
- (2020) Julia M. D. Grandjean et al. Nature Chemical Biology
- The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum
- (2019) G. Elif Karagöz et al. Cold Spring Harbor Perspectives in Biology
- Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
- (2019) Erik A. Blackwood et al. Nature Communications
- N-acetylcysteine protects testicular tissue against ischemia/reperfusion injury via inhibiting endoplasmic reticulum stress and apoptosis
- (2019) I.O. Kazaz et al. Journal of Pediatric Urology
- Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality
- (2019) Eloise Hudry et al. NEURON
- Endoplasmic reticulum stress: a key player in human disease
- (2019) Stefan J. Marciniak FEBS Journal
- Targeting of the unfolded protein response (UPR) as therapy for Parkinson's disease
- (2019) Alexis Martinez et al. BIOLOGY OF THE CELL
- Nitrosative stress drives heart failure with preserved ejection fraction
- (2019) Gabriele G. Schiattarella et al. NATURE
- Proteostasis and Beyond: ATF6 in Ischemic Disease
- (2019) Christopher C. Glembotski et al. TRENDS IN MOLECULAR MEDICINE
- Pharmacological targeting of the unfolded protein response for disease intervention
- (2019) Claudio Hetz et al. Nature Chemical Biology
- The EMBL-EBI search and sequence analysis tools APIs in 2019
- (2019) Fábio Madeira et al. NUCLEIC ACIDS RESEARCH
- Small Molecules to Improve ER Proteostasis in Disease
- (2019) Vicente Gonzalez-Teuber et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau
- (2019) Sarah M. Waldherr et al. Nature Communications
- Proteostasis In The Endoplasmic Reticulum: Road to Cure
- (2019) Nam et al. Cancers
- A new model to study cell-to-cell transfer of αSynuclein in vivo
- (2018) Gabriela Mercado et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Endoplasmic Reticulum Stress Response in Neuroprogressive Diseases: Emerging Pathophysiological Role and Translational Implications
- (2018) Gerwyn Morris et al. MOLECULAR NEUROBIOLOGY
- Gene Therapy Strategies to Restore ER Proteostasis in Disease
- (2018) Vicente Valenzuela et al. MOLECULAR THERAPY
- ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells
- (2018) Si Wang et al. Cell Discovery
- Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases
- (2018) Claudio Soto et al. NATURE NEUROSCIENCE
- Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins
- (2018) Ryan Paxman et al. eLife
- The endoplasmic reticulum (ER) chaperone BiP is a master regulator of ER functions: Getting by with a little help from ERdj friends
- (2018) Kristine Faye R. Pobre et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The PRIDE database and related tools and resources in 2019: improving support for quantification data
- (2018) Yasset Perez-Riverol et al. NUCLEIC ACIDS RESEARCH
- RCSB Protein Data Bank: biological macromolecular structures enabling research and education in fundamental biology, biomedicine, biotechnology and energy
- (2018) Stephen K Burley et al. NUCLEIC ACIDS RESEARCH
- Clinical Gene Therapy for Neurodegenerative Diseases: Past, Present, and Future
- (2017) Françoise Piguet et al. HUMAN GENE THERAPY
- ER stress and the unfolded protein response in neurodegeneration
- (2017) Claudio Hetz et al. Nature Reviews Neurology
- The unfolded protein response: mechanisms and therapy of neurodegeneration
- (2016) Heather L. Smith et al. BRAIN
- Protein aggregation and ER stress
- (2016) Navit Ogen-Shtern et al. BRAIN RESEARCH
- Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction
- (2016) Junli Liu et al. CELL
- ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the HeartNovelty and Significance
- (2016) Jung-Kang Jin et al. CIRCULATION RESEARCH
- Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease
- (2016) José R. Naranjo et al. JOURNAL OF CLINICAL INVESTIGATION
- The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model
- (2016) M Cissé et al. MOLECULAR PSYCHIATRY
- Protein misfolding in the endoplasmic reticulum as a conduit to human disease
- (2016) Miao Wang et al. NATURE
- Understanding Dopaminergic Cell Death Pathways in Parkinson Disease
- (2016) Patrick P. Michel et al. NEURON
- Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
- (2016) Lars Plate et al. eLife
- Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury
- (2016) Maritza Oñate et al. Scientific Reports
- The unfolded protein response in neurodegenerative diseases: a neuropathological perspective
- (2015) Wiep Scheper et al. ACTA NEUROPATHOLOGICA
- Multiple Mechanisms of Unfolded Protein Response–Induced Cell Death
- (2015) Nobuhiko Hiramatsu et al. AMERICAN JOURNAL OF PATHOLOGY
- Endoplasmic Reticulum Stress in Immunity
- (2015) Sarah E. Bettigole et al. Annual Review of Immunology
- The Role of Endoplasmic Reticulum Stress in Human Pathology
- (2015) Scott A. Oakes et al. Annual Review of Pathology-Mechanisms of Disease
- Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death
- (2015) A-L Mahul-Mellier et al. CELL DEATH AND DIFFERENTIATION
- The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein
- (2015) Mauricio Torres et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Gene therapy in Parkinson′s disease: targeting the endoplasmic reticulum proteostasis network
- (2015) Gabriela Mercado et al. Neural Regeneration Research
- The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons
- (2015) Maxim Salganik et al. NEUROBIOLOGY OF AGING
- Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor 1
- (2014) Lisa M. Ryno et al. ACS Chemical Biology
- Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway
- (2014) Zhao V. Wang et al. CELL
- Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity
- (2014) Matthew T. Weirauch et al. CELL
- XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
- (2014) Xi Chen et al. NATURE
- Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1
- (2014) P. Valdes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Design of a bZip Transcription Factor with Homo/Heterodimer-Induced DNA-Binding Preference
- (2014) Vivian Pogenberg et al. STRUCTURE
- When ER stress reaches a dead end
- (2013) Hery Urra et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Role of the unfolded protein response in organ physiology: Lessons from mouse models
- (2013) Víctor Hugo Cornejo et al. IUBMB LIFE
- ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
- (2013) Jaeseok Han et al. NATURE CELL BIOLOGY
- Identification and Rescue of -Synuclein Toxicity in Parkinson Patient-Derived Neurons
- (2013) C. Y. Chung et al. SCIENCE
- An ERcentric view of Parkinson's disease
- (2013) Gabriela Mercado et al. TRENDS IN MOLECULAR MEDICINE
- Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments
- (2013) Matthew D. Shoulders et al. Cell Reports
- AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington’s disease
- (2012) Amparo Zuleta et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy
- (2012) Rene L. Vidal et al. HUMAN MOLECULAR GENETICS
- The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism
- (2012) Yingfeng Deng et al. JOURNAL OF CLINICAL INVESTIGATION
- Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
- (2012) Kelvin C. Luk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Endoplasmic Reticulum Stress Is Important for the Manifestations of -Synucleinopathy In Vivo
- (2012) E. Colla et al. JOURNAL OF NEUROSCIENCE
- The specialized unfolded protein response of B lymphocytes: ATF6α-independent development of antibody-secreting B cells
- (2012) Ileana V. Aragon et al. MOLECULAR IMMUNOLOGY
- The unfolded protein response: controlling cell fate decisions under ER stress and beyond
- (2012) Claudio Hetz NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Activation of the Unfolded Protein Response Is an Early Event in Alzheimers and Parkinsons Disease
- (2012) Jeroen J.M. Hoozemans et al. Neurodegenerative Diseases
- Differential Effects of Unfolded Protein Response Pathways on Axon Injury-Induced Death of Retinal Ganglion Cells
- (2012) Yang Hu et al. NEURON
- ATF6alpha Promotes Astroglial Activation and Neuronal Survival in a Chronic Mouse Model of Parkinson’s Disease
- (2012) Koji Hashida et al. PLoS One
- Activation of the unfolded protein response enhances motor recovery after spinal cord injury
- (2012) V Valenzuela et al. Cell Death & Disease
- ESpritz: accurate and fast prediction of protein disorder
- (2011) Ian Walsh et al. BIOINFORMATICS
- The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis
- (2011) Kezhong Zhang et al. EMBO JOURNAL
- The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins
- (2011) Cherine Belal et al. HUMAN MOLECULAR GENETICS
- The ER stress factor XBP1s prevents amyloid-β neurotoxicity
- (2011) Sergio Casas-Tinto et al. HUMAN MOLECULAR GENETICS
- The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology
- (2011) R. Asada et al. JOURNAL OF BIOCHEMISTRY
- Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
- (2011) Ira Tabas et al. NATURE CELL BIOLOGY
- Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction
- (2011) Yingjiang Zhou et al. NATURE MEDICINE
- The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α
- (2011) Claudio Hetz et al. PHYSIOLOGICAL REVIEWS
- The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
- (2011) P. Walter et al. SCIENCE
- The Endoplasmic Reticulum Stress Sensor, ATF6α, Protects against Neurotoxin-induced Dopaminergic Neuronal Death
- (2010) Naohiro Egawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson’s disease
- (2010) Arianna Bellucci et al. JOURNAL OF NEUROCHEMISTRY
- The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo
- (2010) Carin A. Loewen et al. PLoS One
- Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78
- (2010) M. S. Gorbatyuk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Single Nucleotide Variants of the TGACTCA Motif Modulate Energetics and Orientation of Binding of the Jun-Fos Heterodimeric Transcription Factor†
- (2009) Kenneth L. Seldeen et al. BIOCHEMISTRY
- BLAST+: architecture and applications
- (2009) Christiam Camacho et al. BMC BIOINFORMATICS
- IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates
- (2009) Dan Han et al. CELL
- Regulated Ire1-dependent decay of messenger RNAs in mammalian cells
- (2009) Julie Hollien et al. JOURNAL OF CELL BIOLOGY
- ATF6 induces XBP1-independent expansion of the endoplasmic reticulum
- (2009) H. Bommiasamy et al. JOURNAL OF CELL SCIENCE
- Improved prediction of protein side-chain conformations with SCWRL4
- (2009) Georgii G. Krivov et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Protective effect against Parkinson's disease-related insults through the activation of XBP1
- (2008) Megumi Sado et al. BRAIN RESEARCH
- ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum
- (2008) Yusuke Adachi et al. CELL STRUCTURE AND FUNCTION
- Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity
- (2008) M. L. Duennwald et al. GENES & DEVELOPMENT
- VAPB interacts with and modulates the activity of ATF6
- (2008) C. Gkogkas et al. HUMAN MOLECULAR GENETICS
- CBF/NF-Y controls endoplasmic reticulum stress induced transcription through recruitment of both ATF6(N) and TBP
- (2008) Rong Luo et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Adapting Proteostasis for Disease Intervention
- (2008) William E. Balch et al. SCIENCE
- Activating transcription factor 4
- (2007) Kurosh Ameri et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now