Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology

Heparan sulfate is a clearance receptor for aberrant extracellular proteins

(2020) Eisuke Itakura et al.   JOURNAL OF CELL BIOLOGY

Brain ApoA-I, ApoJ and ApoE Immunodetection in Cerebral Amyloid Angiopathy

(2019) Jessica Camacho et al.   Frontiers in Neurology

Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies

(2019) Evangeline M. Foster et al.   Frontiers in Neuroscience

Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate

(2019) Yang He et al.   Nature Communications

The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

(2018) Fabia Filipello et al.   IMMUNITY

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

(2018) Laetitia Weinhard et al.   Nature Communications

Quantitative Proteomic Analysis of the Hippocampus in the 5XFAD Mouse Model at Early Stages of Alzheimer's Disease Pathology

(2018) Ingie Hong et al.   JOURNAL OF ALZHEIMERS DISEASE

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

(2018) Heidi Martini-Stoica et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of diverse astrocyte populations and their malignant analogs

(2017) Chia-Ching John Lin et al.   NATURE NEUROSCIENCE

Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation

(2017) Isabella Farhy-Tselnicker et al.   NEURON

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

(2017) Aleksandra M. Wojtas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ

(2016) J. Scott Miners et al.   BRAIN PATHOLOGY

Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin

(2016) Sandeep K. Singh et al.   CELL

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer’s disease risk genes

(2016) Silvia S. Kang et al.   HUMAN MOLECULAR GENETICS

Clusterin Binds to Aβ1–42Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation

(2016) Marten Beeg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts

(2016) Lin Tan et al.   Scientific Reports

Alzheimer's disease risk variant in CLU is associated with neural inefficiency in healthy individuals

(2015) Thomas M. Lancaster et al.   Alzheimers & Dementia

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes

(2015) Sébastien Sultan et al.   NEURON

Clusterin Is a Ligand for Apolipoprotein E Receptor 2 (ApoER2) and Very Low Density Lipoprotein Receptor (VLDLR) and Signals via the Reelin-signaling Pathway

(2014) Christian Leeb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined Effects of Alzheimer Risk Variants in the CLU and ApoE Genes on Ventricular Expansion Patterns in the Elderly

(2014) F. F. Roussotte et al.   JOURNAL OF NEUROSCIENCE

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

Evaluation of memory endophenotypes for association with CLU, CR1, and PICALM variants in black and white subjects

(2013) Otto Pedraza et al.   Alzheimers & Dementia

Synaptic deficits in layer 5 neurons precede overt structural decay in 5xFAD mice

(2013) Y. Buskila et al.   NEUROSCIENCE

Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain

(2013) Paramita Chakrabarty et al.   PLoS One

Alzheimer Risk Variant CLU and Brain Function During Aging

(2012) Madhav Thambisetty et al.   BIOLOGICAL PSYCHIATRY

Astrocyte-induced Synaptogenesis Is Mediated by Transforming Growth Factor β Signaling through Modulation of d-Serine Levels in Cerebral Cortex Neurons

(2012) Luan Pereira Diniz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

(2012) M. Allen et al.   NEUROLOGY

Genetics of Clusterin Isoform Expression and Alzheimer's Disease Risk

(2012) I-Fang Ling et al.   PLoS One

Common Alzheimer's Disease Risk Variant Within the CLU Gene Affects White Matter Microstructure in Young Adults

(2011) M. N. Braskie et al.   JOURNAL OF NEUROSCIENCE

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide

(2011) Priyanka Narayan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

(2009) Çagla Eroglu et al.   CELL

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS