Article
Biochemistry & Molecular Biology
Wenjing Li, Yinhua Zhou, Zhaofan Luo, Rixin Tang, Yuxuan Sun, Qiangsheng He, Bin Xia, Kuiqing Lu, Qinghua Hou, Jinqiu Yuan
Summary: This study aims to construct a lipid score system to predict the risk of progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). The results showed that the lipid score system based on serum lipidomics can accurately predict the progression risk from MCI to AD.
Article
Biochemistry & Molecular Biology
Aida Kamalian, Sara G. Ho, Megha Patel, Alexandria Lewis, Arnold Bakker, Marilyn Albert, Richard J. O'Brien, Abhay Moghekar, Michael W. Lutz
Summary: This study measured 3072 proteins in the CSF samples of AD-biomarker positive MCI patients and controls, and found an upregulation of neuroinflammatory pathways, particularly chemotactic and granulocyte recruitment pathways, in the CSF of early AD patients.
Article
Neurosciences
Xiaomei Zhong, Ben Chen, Le Hou, Qiang Wang, Meiling Liu, Mingfeng Yang, Min Zhang, Huarong Zhou, Zhangying Wu, Si Zhang, Gaohong Lin, Yuping Ning
Summary: This study aimed to compare temporal variability in the spontaneous fluctuations of activity and connectivity between amnestic MCI (aMCI) and nonamnestic MCI (naMCI). The results showed that both aMCI and naMCI patients exhibited abnormal brain activity and connectivity. The variability in dALFF, dReHo, and hippocampal dFC was different between aMCI and naMCI patients and was associated with cognitive scores. The dReHo of the superior parietal lobule and dFC of the hippocampus-cerebellum contributed to the memory heterogeneity of MCI subtypes.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Vidyulata Kamath, Matthew L. Senjem, Anthony J. Spychalla, Honglei Chen, Priya Palta, Thomas H. Mosley, B. Gwen Windham, Michael Griswold, David S. Knopman, Rebecca F. Gottesman, Clifford R. Jack, A. Richey Sharrett, Andrea L. C. Schneider
Summary: Impaired olfactory identification is associated with smaller neuroanatomical regions in individuals without dementia, which are the primary targets of AD pathogenic processes.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Amanda Cano, Ester Esteban-de-Antonio, Mireia Bernuz, Raquel Puerta, Pablo Garcia-Gonzalez, Itziar de Rojas, Claudia Olive, Alba Perez-Cordon, Laura Montrreal, Raul Nunez-Llaves, Oscar Sotolongo-Grau, Emilio Alarcon-Martin, Sergi Valero, Montserrat Alegret, Elvira Martin, Pamela V. Martino-Adami, Miren Ettcheto, Antonio Camins, Assumpta Vivas, Marta Gomez-Chiari, Miguel angel Tejero, Adelina Orellana, Lluis Tarraga, Marta Marquie, Alfredo Ramirez, Merce Marti, Maria Isabel Pividori, Merce Boada, Agustin Ruiz
Summary: Alzheimer's disease (AD) is commonly preceded by a prodromal phase characterized by high levels of A beta and p-tau-mediated neuronal injury and mild cognitive impairment (MCI). Differential diagnosis of MCI causes in these prodromal stages is a challenge for clinicians. Blood biomarkers, particularly plasma extracellular vesicles (pEVs), are emerging as potential tools for early AD detection.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Clinical Neurology
Aurore Delvenne, Johan Gobom, Betty Tijms, Isabelle Bos, Lianne M. Reus, Valerija Dobricic, Mara Ten Kate, Frans Verhey, Inez Ramakers, Philip Scheltens, Charlotte E. Teunissen, Rik Vandenberghe, Jolien Schaeverbeke, Silvy Gabel, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Magda Tsolaki, Yvonne Freund-Levi, Simon Lovestone, Johannes Streffer, Frederik Barkhof, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Pieter Jelle Visser, Stephanie J. B. Vos
Summary: The pathophysiology of MCI-SNAP is distinct from that of MCI-AD, highlighting the need for different treatment approaches.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biology
Zoya O. Serebrovska, Lei Xi, Lesya Tumanovska, Angela M. Shysh, Sergii Goncharov, Michael Khetsuriani, Taisia O. Kozak, Denis A. Pashevin, Victor E. Dosenko, Sergii V. Virko, Viktor A. Kholin, Oksana N. Grib, Natalie A. Utko, Egor Egorov, Anna O. Polischuk, Tetiana Serebrovska
Summary: The study investigated the effects of intermittent hypoxia-hyperoxia training (IHHT) on pro-inflammatory factors in healthy elderly individuals and patients with early signs of Alzheimer's disease (AD). IHHT was found to improve cognitive function, potentially through upregulating circulating levels of inflammatory markers and triggering cellular adaptive reprogramming.
Article
Geriatrics & Gerontology
Joel Eyamu, Wuon-Shik Kim, Kahye Kim, Kun Ho Lee, Jaeuk U. Kim
Summary: This study examined cognitive deficits and behavioral changes in patients with mild cognitive impairment (MCI) using prefrontal selective attention event-related potential (ERP) recorded from a prefrontal two-channel electroencephalography (EEG) device. The results showed that patients with MCI had slower information processing abilities and poorer task execution compared to cognitively normal adults. Multiple logistic regression analysis confirmed the association between some ERP and behavioral measures with MCI prevalence, independent of demographic and neuropsychological factors. There was a relationship observed between neuropsychological scores, ERP, and behavioral measures.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Akram A. Hosseini, Thomas Brown, Luca Mannino, Bruno Gran, Kehinde Junaid, Elizabeta B. Mukaetova-Ladinska
Summary: This study conducted diagnostic lumbar puncture in patients with early onset Alzheimer's or related dementias and evaluated the measurements of amyloid-beta 42 (A beta(42)), total tau, and Thr181-phosphorylated tau (p-tau) in the cerebrospinal fluid (CSF). The results showed that low levels of CSF A beta(42) appear to be more sensitive than total and p-tau measures in differentiating AD MCI from other forms of dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Catarina Bernardes, Marisa Lima, Diana Duro, Anuschka Silva-Spinola, Joao Duraes, Miguel Tabuas-Pereira, Ines Baldeiras, Sandra Freitas, Isabel Santana
Summary: This study confirms the role of cerebrospinal fluid Alzheimer's disease biomarkers in predicting conversion from mild cognitive impairment to dementia and suggests the utility of Montreal Cognitive Assessment in predicting conversion in highly educated subjects, supporting its use in the evaluation of MCI patients.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Zahinoor Ismail, Rebeca Leon, Byron Creese, Clive Ballard, Philippe Robert, Eric E. Smith
Summary: This study investigated the association between mild behavioral impairment (MBI) in mild cognitive impairment (MCI) and Alzheimer's disease (AD), and found that adding MBI to MCI can better identify AD and improve dementia prognostication. Therefore, the addition of MBI is important for the detection of AD.
MOLECULAR NEURODEGENERATION
(2023)
Article
Neurosciences
Alexandra L. Clark, Alexandra J. Weigand, Kelsey R. Thomas, Seraphina K. Solders, Lisa Delano-Wood, Mark W. Bondi, Rachel A. Bernier, Erin E. Sundermann, Sarah J. Banks, Katherine J. Bangen
Summary: The study revealed differential effects of pulse pressure and inflammation on Alzheimer's disease-related cerebrospinal fluid proteins, indicating that vascular risk is associated with greater AD pathology in both cognitively normal and mild cognitive impairment older adults.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Kate J. Russin, K. Sreekumaran Nair, Thomas J. Montine, Laura D. Baker, Suzanne Craft
Summary: This study aimed to investigate the impact of diets with different nutrient compositions on cerebrospinal fluid amino acid levels, finding that a high saturated fat/glycemic index diet can lead to changes in amino acid levels in individuals with mild cognitive impairment. The response to diet intervention varies according to cognitive status.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Immunology
Juan Yang, Lingling Wang, Huiqin Liu, Hui Xu, Feng Liu, Haihan Song, Xiaohui Zhao, Hongqiang Li
Summary: This study investigated the features of intestinal flora in patients with rapidly progressive MCI. The results showed significant differences in the abundance of intestinal microflora between patients with progressive MCI and patients without progression at the baseline. Further analysis revealed that the decrease of Ruminococcaceae abundance and the increase of Megamonas abundance were closely correlated with the progression of MCI.
MICROBIAL PATHOGENESIS
(2023)
Article
Clinical Neurology
Tobey J. Betthauser, Murat Bilgel, Rebecca L. Koscik, Bruno M. Jedynak, Yang An, Kristina A. Kellett, Abhay Moghekar, Erin M. Jonaitis, Charles K. Stone, Corinne D. Engelman, Sanjay Asthana, Bradley T. Christian, Dean F. Wong, Marilyn Albert, Susan M. Resnick, Sterling C. Johnson
Summary: Alzheimer's disease biomarkers are crucial for understanding disease progression and predicting symptoms. This study develops and evaluates methods for modeling amyloid accumulation and investigates factors influencing the timing of amyloid onset and impairment onset. The findings suggest that APOE genotype, rather than sex, is associated with amyloid onset age, and that higher APOEe4 dosage, being female, and older amyloid onset age shorten the time from amyloid onset to dementia.
Article
Environmental Sciences
He-Ying Hu, Ya-Hui Ma, Yue-Ting Deng, Ya-Nan Ou, Wei Cheng, Jian-Feng Feng, Lan Tan, Jin-Tai Yu
Summary: This study found an association between residential greenness and dementia incidence, indicating that increasing greenspace can reduce the risk of dementia. The protective effect of greenness may be mediated through the reduction of particulate air pollution.
ENVIRONMENTAL RESEARCH
(2023)
Article
Cell Biology
Xin-Xin Fu, Rui Duan, Si-Yu Wang, Qiao-Quan Zhang, Bin Wei, Ting Huang, Peng-Yu Gong, Yan E, Teng Jiang, Ying-Dong Zhang
Summary: This study found that lamotrigine treatment can improve cognitive function and pathological damage related to Alzheimer's disease. The beneficial effects may be mediated by the regulation of specific gene expression in the brain. These results suggest that lamotrigine may be a promising therapeutic drug for Alzheimer's disease.
NEURAL REGENERATION RESEARCH
(2023)
Article
Cell Biology
Si-Yu Wang, Xin-Xin Fu, Rui Duan, Bin Wei, Hai-Ming Cao, E. Yan, Shuai-Yu Chen, Ying-Dong Zhang, Teng Jiang
Summary: This study provides evidence that TREML2 modulates inflammation by regulating microglial polarization and NLRP3 inflammasome activation, suggesting a novel therapeutic strategy for Alzheimer's disease (AD).
NEURAL REGENERATION RESEARCH
(2023)
Article
Neurosciences
Hai-Ming Cao, Hui-Wen Lian, Yan E, Rui Duan, Jun-Shan Zhou, Xiang-Liang Chen, Teng Jiang
Summary: The long-term effect of dual antiplatelet therapy (DAPT) using clopidogrel plus aspirin versus aspirin monotherapy after intravenous thrombolysis on functional outcomes in patients with minor stroke was investigated. The study found that DAPT was associated with improved functional outcome at the 1-year follow-up for patients with minor stroke, without increasing the stroke recurrence rate and mortality.
Article
Biology
Nirmal Verma, Gopal Viswanathan Velmurugan, Edric Winford, Han Coburn, Deepak Kotiya, Noah Leibold, Laura Radulescu, Sanda Despa, Kuey C. Chen, Linda J. Van Eldik, Peter T. Nelson, Donna M. Wilcock, Gregory A. Jicha, Ann M. Stowe, Larry B. Goldstein, David K. Powel, Jeffrey H. Walton, Manuel F. Navedo, Matthew A. Nystoriak, Andrew J. Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Florin Despa
Summary: Impairment of vascular pathways contributes to Alzheimer's disease. Blood amylin secreted from the pancreas perturbs cerebral A beta clearance, leading to amylin and A beta co-deposits in the brain microvasculature. Altering bloodborne amylin could potentially reduce cerebrovascular amylin deposits and A beta pathology.
COMMUNICATIONS BIOLOGY
(2023)
Review
Clinical Neurology
Na Zhang, Ke-Liang Chen, Yu-Yuan Huang, Shu-Fen Chen, Qiang Dong, Lan Tan, Jin-Tai Yu
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Neurosciences
Zuo-Teng Wang, Yan Fu, Shi-Dong Chen, Yu-Yuan Huang, Ya-Hui Ma, Yan-Jiang Wang, Lan Tan, Jin-Tai Yu
Summary: This study is the first to identify significant associations between TREM1 rs2062323 and AD risk. The rs2062323T may be involved in AD by regulating the expression of TREM1, TREML1, TREM2, and sTREM2. The TREM family is expected to be a potential therapeutic target for AD.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Yan Fu, Yan Sun, Zhi-Bo Wang, Dan-Dan Zhang, Lan Tan, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: This study used the American Heart Association's Life's Simple 7 (LS7) metric to define cardiovascular and brain health and found that ideal LS7 cardiovascular health factors are associated with both macrostructural and microstructural markers of brain health. The results suggest that better LS7 profiles are linked to better brain health.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Xin-Xin Fu, Bin Wei, Hai-Ming Cao, Rui Duan, Yang Deng, Hui-Wen Lian, Ying-Dong Zhang, Teng Jiang
Summary: TEL has shown promising effects in the prevention and treatment of AD. It improves cognitive and executive impairments, reduces neuronal and synaptic injury, Aβ pathology, neuroinflammation, and oxidative stress. The beneficial effects of TEL are achieved by inhibiting Aβ production and promoting Aβ degradation, as well as through its anti-inflammatory effects via microglial pathways. Early administration of TEL can also prevent the onset of AD-related symptoms.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Yan Sun, Yu Guo, Hong-Qi Li, Lan Tan, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: White matter hyperintensities (WMH) are strongly associated with stroke, dementia, and early mortality. This study investigated the relationship between WMH and circulating metabolites in a large sample of individuals from the UK Biobank. The results showed that several metabolites, including high-density lipoprotein (HDL), fatty acids, and glycoprotein acetyls, were associated with WMH. Age and sex also had a significant influence on these associations. The findings suggest that specific metabolomic features accompany WMH and may provide insights into the implications of WMH in different populations.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Xin-Xin Fu, Shuai-Yu Chen, Hui-Wen Lian, Yang Deng, Rui Duan, Ying-Dong Zhang, Teng Jiang
Summary: Previously, the H157Y variant of the TREM2 gene was found to be associated with increased risk of Alzheimer's disease (AD) in Han Chinese population. In this study, using CRISPR-Cas9-engineered BV2 microglia, researchers investigated the effect of the Trem2 H157Y variant on AD-related microglial functions. The findings showed that this variant inhibits microglial phagocytosis, promotes M1-type polarization, and enhances the release of inflammatory cytokines.
Review
Clinical Neurology
Atri Chatterjee, Veronica Hirsch-Reinshagen, Imogene Scott, Neil Cashman, Ging-Yuek Robin Hsiung
Summary: This study conducted a systematic review and found that the frequency of psychosis in FTD patients was 24.2%. Among the genetic mutation carriers, C9orf72 mutation carriers had the highest frequency of psychosis (31.4%), while GRN and MAPT mutation carriers had lower frequencies of psychosis. Among the pathological subtypes, patients with FUS pathology, TDP-43 pathology, and tau pathology had a prevalence of psychosis at 30%, 25.3%, and 16.4% respectively.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
A. Iraji, Z. Fu, A. Faghiri, M. Duda, J. Chen, S. Rachakonda, T. DeRamus, P. Kochunov, B. M. Adhikari, A. Belger, J. M. Ford, D. H. Mathalon, G. D. Pearlson, S. G. Potkin, A. Preda, J. A. Turner, T. G. M. van Erp, J. R. Bustillo, K. Yang, K. Ishizuka, A. Faria, A. Sawa, K. Hutchison, E. A. Osuch, J. Theberge, C. Abbott, B. A. Mueller, D. Zhi, C. Zhuo, S. Liu, Y. Xu, M. Salman, J. Liu, Y. Du, J. Sui, T. Adali, V. D. Calhoun
Summary: This study identifies replicable multi-spatial-scale canonical intrinsic connectivity network (ICN) templates using rsfMRI data from over 100k individuals through multi-model-order independent component analysis (ICA). The feasibility of estimating subject-specific ICNs via spatially constrained ICA is also studied. The results show that subject-level ICN estimations vary as a function of the ICN itself, the data length, and the spatial resolution. Longer scans may not always be desirable and spatial smoothness should be considered in optimizing data length.
HUMAN BRAIN MAPPING
(2023)
Article
Biochemistry & Molecular Biology
Shu-Yi Huang, Ya-Ru Zhang, Liu Yang, Yu-Zhu Li, Bang-Sheng Wu, Shi-Dong Chen, Jian-Feng Feng, Qiang Dong, Wei Cheng, Jin-Tai Yu
Summary: Identifying circulating metabolites associated with dementia, cognition, and brain volume could provide new insights into the pathogenesis of dementia. This cohort study found 26 metabolites associated with incident dementia, including specific associations with Alzheimer's disease (AD) and vascular dementia (VD). Circulating levels of certain lipoproteins were found to be associated with the risk of AD and AD phenotypes, while another lipoprotein was associated with the risk of VD.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ji-Yun Cheng, Yue-Ting Deng, Jin-Tai Yu
Summary: Through a more robust analysis, we found potential associations between circulating levels of amino acids and the risk of neurodegenerative diseases. Increase in circulating levels of Glutamine (Gln) was associated with lower risk of Alzheimer's disease (AD), while increase in circulating levels of Leucine (Leu) was associated with lower risk of Parkinson's disease (PD). Replication tests further confirmed the potential association between circulating Gln levels and AD risk.
JOURNAL OF NEUROCHEMISTRY
(2023)
