期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 143, 期 10, 页码 3734-3740出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.1c00840
关键词
-
资金
- NSFC [21971198, 21772148]
- Natural Science Foundation of Hubei Province [2020CFA036]
This research presents an efficient enantioselective Pd(II)-catalyzed cascade reaction for the transformation of alkyne-tethered malononitriles into alpha-quaternary carbazolones with high enantioselectivities. The utility of this method is demonstrated by the synthesis of diverse heterocycles and a nitrile-containing leucomidine A analog from the obtained products.
An enantioselective Pd(II)-catalyzed amino-cyclization and desymmetrizing nitrile addition cascade reaction of alkyne-tethered malononitriles is reported. This reaction forms two rings and one quaternary carbon center in a single step and serves as an efficient strategy for the construction of alpha-quaternary carbazolones with high enantioselectivities (up to 98:2 er). The utility of this method is demonstrated by product derivatization into a diverse array of heterocycles and a nitrile-containing leucomidine A analog.
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