Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies

Megalin

(2020) Yuan Sun et al.   HYPERTENSION

Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia

(2019) Jelle Vriend et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Recellularized native kidney scaffolds as a novel tool in nephrotoxicity screening

(2018) Michele Fedecostante et al.   DRUG METABOLISM AND DISPOSITION

Advances in predictive in vitro models of drug-induced nephrotoxicity

(2018) Joanne Y.-C. Soo et al.   Nature Reviews Nephrology

Combining Extracellular miRNA Determination with Microfluidic 3D Cell Cultures for the Assessment of Nephrotoxicity: a Proof of Concept Study

(2018) Laura Suter-Dick et al.   AAPS Journal

Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules

(2018) Marianne K. Vormann et al.   AAPS Journal

Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip

(2018) Jelle Vriend et al.   AAPS Journal

Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip

(2018) Courtney Sakolish et al.   Scientific Reports

96 perfusable blood vessels to study vascular permeability in vitro

(2017) V. van Duinen et al.   Scientific Reports

A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity

(2016) Tom T. G. Nieskens et al.   AAPS Journal

Fluorescence-Based Transport Assays Revisited in a Human Renal Proximal Tubule Cell Line

(2016) Pedro Caetano-Pinto et al.   MOLECULAR PHARMACEUTICS

Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening

(2016) Martijn J. Wilmer et al.   TRENDS IN BIOTECHNOLOGY

Modeling Barrier Tissues In Vitro: Methods, Achievements, and Challenges

(2016) Courtney M. Sakolish et al.   EBioMedicine

Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips

(2016) Kimberly A. Homan et al.   Scientific Reports

Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study

(2015) Eric A. J. Hoste et al.   INTENSIVE CARE MEDICINE

A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro

(2015) M. Adler et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-Line Antibiotics against Multidrug-Resistant Gram-Negative Bacteria

(2015) Kade D. Roberts et al.   ACS Infectious Diseases

Tenofovir-induced nephrotoxicity: incidence, mechanism, risk factors, prognosis and proposed agents for prevention

(2014) Atefeh Jafari et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Mitochondrial Dysfunction and Electron Transport Chain Complex Defect in a Rat Model of Tenofovir Disoproxil Fumarate Nephrotoxicity

(2014) Hemalatha Ramamoorthy et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Drug-Induced Nephrotoxicity: Clinical Impact and Preclinical in Vitro Models

(2014) Ho Yee Tiong et al.   MOLECULAR PHARMACEUTICS

Pathophysiology of Cisplatin-Induced Acute Kidney Injury

(2014) Abdullah Ozkok et al.   Biomed Research International

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Renal Transporters in Drug Development

(2012) Kari M. Morrissey et al.   Annual Review of Pharmacology and Toxicology

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Mechanisms of Drug Toxicity and Relevance to Pharmaceutical Development

(2010) F. Peter Guengerich   Drug Metabolism and Pharmacokinetics

Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters

(2009) Martijn J. Wilmer et al.   CELL AND TISSUE RESEARCH

Physicochemical Determinants of Human Renal Clearance

(2009) Manthena V. S. Varma et al.   JOURNAL OF MEDICINAL CHEMISTRY