期刊
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
卷 48, 期 1-2, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/jimb/kuab009
关键词
Forskolin; 13R-manoyl oxide; Cytochrome P450s; Synthetic biology
资金
- National Key Research and Development Project of China [2019YFA0905100]
- National Natural Science Foundation of China [21878220]
Synthetic biological technology is being used to address challenges in traditional natural product extraction, focusing on constructing microbial cell factories to synthesize medicinal substances like forskolin. The research emphasis is on solving current problems and proposing corresponding strategies.
Forskolin, a class of labdane-type diterpenoid, has significant medicinal value in anticancer, antiasthmatic, antihypertensive, and heart-strengthening treatments. The main source of natural forskolin is its extraction from the cork tissue of the root of Coleus forskohlii. However, conventional modes of extraction pose several challenges. In recent years, the construction of microbial cell factories to produce medicinal natural products via synthetic biological methods has effectively solved the current problems and is a research hotspot in this field. This review summarizes the recent progress in the heterologous synthesis of forskolin via synthetic biological technology, analyzes the current challenges, and proposes corresponding strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据