Review
Polymer Science
Suguna Perumal, Raji Atchudan, Wonmok Lee
Summary: This review discusses the self-assembly of amphiphilic polymers into micelles (polymeric nanoparticles) and their importance in bio-applications. Micelles, with their unique properties, size, shape, and biocompatibility, enhance drug loading and target release, making them a research focus in the field of biomedicine.
Review
Biotechnology & Applied Microbiology
Rubiya Khursheed, Keshav R. Paudel, Monica Gulati, Sukriti Vishwas, Niraj Kumar Jha, Philip M. Hansbro, Brian G. Oliver, Kamal Dua, Sachin Kumar Singh
Summary: This review focuses on the application of polymeric micelles (PMs) in pulmonary drug delivery, including encapsulation of hydrophobic drugs, enhancing drug targeting and reducing side effects. These techniques play an important role in the treatment of pulmonary diseases.
Review
Pharmacology & Pharmacy
Irina Negut, Bogdan Bita
Summary: Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The advancement in the field of material science and nanomedicine has led to improved drug delivery systems with proven efficacy and fewer side effects. Various intelligent nanomedicines are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Thorough knowledge of these nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are simple to make and have high solubilization characteristics, making them a promising alternative in nanosystems for cancer treatment.
Article
Chemistry, Physical
Zhongjie Fei, Mehdi Yoosefian
Summary: This study investigates the assembly mechanism of Ribociclib encapsulated by DPC micelle using all-atom molecular dynamics simulations. The main forces involved in the drug encapsulation process are hydrophobic and van der Waals interactions, with hydrogen bonding and electrostatic interactions also contributing. Solvent accessible surface area and radial distribution function analyses show that DPC micelles can improve the aqueous solubility of hydrophobic drugs, providing a new pathway for designing drug delivery systems with necessary properties.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Yang Han, Jieyi Pan, Na Liang, Xianfeng Gong, Shaoping Sun
Summary: The study synthesized an amphiphilic conjugate based on mPEG and cholesterol-modified chitosan with hydrazone bonds, which was used to prepare PTX-loaded micelles. These micelles exhibited promising therapeutic efficacy of PTX and reduced side effects, indicating potential as pH-sensitive nanocarriers for drug delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Transplantation
Gianmarco Sabiu, Vivek Kasinath, Sungwook Jung, Xiaofei Li, George C. Tsokos, Reza Abdi
Summary: Kidney diseases are a significant global health problem with limited treatment options. Nanomedicines, as novel drug-delivery systems, show great promise in the treatment of kidney diseases. However, there are limitations hindering their clinical application.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Pharmacology & Pharmacy
Keerti Mishra, Pooja Ratre, Suresh Thareja, Akhlesh K. Jain
Summary: Breast cancer is emerging worldwide with an alarming rate, specifically in post-menopausal women, and it is mostly caused because of estrogen. Aromatase inhibitors and estrogen synthesis inhibitors could prevent chances of breast cancer.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Pharmacology & Pharmacy
Sabna Kotta, Hibah Mubarak Aldawsari, Shaimaa M. Badr-Eldin, Anroop B. Nair, Y. T. Kamal
Summary: Polymeric micelles (PMs) have shown significant progress in drug delivery applications due to their robust core-shell structure and ability to solubilize hydrophobic drugs. This review presents the recent advances and understandings of PMs, including preparation methods, applications, and tumor-targeted delivery.
Review
Chemistry, Multidisciplinary
Jaskiran Kaur, Vijay Mishra, Sachin Kumar Singh, Monica Gulati, Bhupinder Kapoor, Dinesh Kumar Chellappan, Gaurav Gupta, Harish Dureja, Krishnan Anand, Kamal Dua, Gopal L. Khatik, Kuppusamy Gowthamarajan
Summary: Amphiphilic block copolymers are widely used in drug delivery for enhancing bioavailability, molecular targeting, and sustained release. However, challenges such as premature drug release, low drug loading capacity, and poor stability need to be addressed for wider clinical utility. Future studies should focus on exploring their full potential in the treatment and diagnosis of diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Oveis Pourmehran, Kavan Zarei, Jeremie Pourchez, Sarah Vreugde, Alkis Psaltis, Peter-John Wormald
Summary: Chronic rhinosinusitis (CRS) has a negative impact on patients' quality of life and healthcare expenditures. Traditional drug delivery methods for CRS, like nasal sprays and irrigation, have limited effectiveness. Acoustic Drug Delivery (ADD) using a nebulizer allows targeted delivery of drugs to the sinuses, potentially improving treatment outcomes. This review examines the effects of aerosol particle characteristics, aero-acoustic parameters, flow conditions, and acoustic waves on sinus drug delivery. Key findings suggest that smaller particles enhance ADD efficiency, while larger sizes or increased density hinder it. The oscillation amplitude of the air plug at the ostium is crucial for ADD efficiency. Introducing acoustic waves at the resonance frequency of the nasal cavity-sinus system can improve aerosol deposition in the sinuses. Future research should focus on advanced models, optimizing particle characteristics, investigating novel acoustic waveforms, incorporating patient-specific anatomy, and evaluating long-term safety and efficacy. Addressing these challenges, ADD could provide more effective and targeted treatments for sinus-related conditions like CRS.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Balaram Ghosh, Swati Biswas
Summary: Polymeric micelles are extensively used for delivering poorly soluble chemotherapeutic agents in cancer treatment. These micelles can be easily tailored by self-assembly of amphiphilic polymers to optimize drug loading, stability, and delivery to target tissues. The current trend focuses on developing various block polymeric micelles and stimuli-sensitive micelles to enhance therapeutic activity.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Shixian Lv, Meilyn Sylvestre, Kefan Song, Suzie H. Pun
Summary: Melittin, the primary peptide component in bee venom, has anti-tumor activity but its practical application is hindered by hemolytic activity and instability. Use of D-amino acids in place of L-amino acids reduces immunogenicity of melittin, allowing for safer delivery and maintaining cytolytic potential. D-melittin micelles show cytotoxicity in a pH-dependent manner, inducing immunogenic cell death and demonstrating potential for cancer immunotherapy. The study presents a new strategy for systemic delivery of cytotoxic peptides in cancer treatment.
Article
Pharmacology & Pharmacy
Maria Antonia Tanase, Adina Raducan, Petruta Oancea, Lia Mara Ditu, Miruna Stan, Cristian Petcu, Cristina Scomoroscenco, Claudia Mihaela Ninciuleanu, Cristina Lavinia Nistor, Ludmila Otilia Cinteza
Summary: Novel polymeric mixed micelles from Pluronic F127 and Cremophor EL were studied as drug delivery systems for Norfloxacin. The optimal molar ratio of surfactants was determined to prepare carriers with minimal surfactant concentrations. The mixed micelles showed tunable extended release of Norfloxacin and good activity against clinical isolated strains, while some cytotoxicity was found at high concentrations.
Article
Polymer Science
Fernanda Lapa Campos, Janaina de Alcantara Lemos, Caroline Mari Ramos Oda, Juliana de Oliveira Silva, Renata Salgado Fernandes, Sued Eustaquio Mendes Miranda, Carolina Henriques Cavalcante, Geovanni Dantas Cassali, Danyelle M. Townsend, Elaine Amaral Leite, Andre Luis Branco de Barros
Summary: Colorectal cancer is a significant global public health issue due to the ineffectiveness of current treatments. This study proposes micellar formulations as a novel targeted drug delivery system for colorectal cancer therapy. The micelles showed promising characteristics such as small size, neutral charge, and high encapsulation efficiency. Animal experiments demonstrated that the micellar formulations effectively inhibited tumor growth with low toxicity at an appropriate dosage.
Review
Pharmacology & Pharmacy
Ziaul Karim, Preeti Karwa, Shobha Rani R. Hiremath
Summary: Transdermal drug delivery is a highly attractive route for administering pharmaceutical active ingredients. Microneedle technology, with its advantages of efficiency, painlessness, reliability, and feasibility, has gained prominence in transdermal drug delivery. Different types of microneedles can be made using various materials based on the delivery mechanism, offering promising applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Duy Toan Pham, Doan Xuan Tien Nguyen, Ruby Lieu, Quoc Cuong Huynh, Ngoc Yen Nguyen, Tran Thi Bich Quyen, Van De Tran
Summary: This study investigated the ability of silk fibroin nanoparticles (SFNs) to encapsulate, deliver, and heat-protect the phenolic compounds of guava leaves ethanolic extract. The SFNs successfully encapsulated the extract and preserved its antioxidant activity, demonstrating their potential in protecting other natural compounds from environmental factors.
Article
Engineering, Biomedical
Premchirakorn Phewchan, Artit Laoruengthana, Waree Tiyaboonchai
Summary: Bone defect remains a challenging issue in orthopedic practice, and there is growing interest in injectable bone substitutes that can fill different bone defect geometries and improve the biological environment for bone regeneration. Silk fibroin (SF) is a notable polymer due to its biocompatible and biodegradable properties. In this study, composite injectable hydrogels incorporating calcium phosphate particles (CAPs) in SF and methylcellulose (MC) were developed and compared to assess their physicochemical properties.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Duy Toan Pham, Thanh Lich Nguyen, Thi Truc Linh Nguyen, Thi Truc Phuong Nguyen, Tuan Kiet Ho, Ngoc Yen Nguyen, Van De Tran, Thi Kim Quy Ha
Summary: Limited studies have explored the use of silk fibroin as an oral drug delivery system. This study developed and characterized polyethylenimine-functionalized fibroin nanoparticles (PEI-FNP) loaded with furosemide for oral application. The PEI-FNP demonstrated improved drug solubility and potential for enhancing the oral bioavailability of furosemide.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Multidisciplinary Sciences
Duyen Thi My Huynh, Huynh Thien Hai, Nguyen Minh Hau, Huynh Kim Lan, Truong Phu Vinh, Van De Tran, Duy Toan Pham
Summary: By preparing and characterizing effervescent granules containing azithromycin solid dispersion, we successfully addressed the issues of swallowing difficulty, inefficient absorption, poor solubility, bitter taste, and instability of azithromycin in the stomach acidic condition in children and elder population. The optimized solid dispersion greatly enhanced the solubility of azithromycin, improved its taste, formed intermolecular bonding, and transformed the drug molecules from crystalline to amorphous state. The final effervescent granules formulation met all the requirements stated in the Vietnamese Pharmacopoeia and can be further investigated as a potential azithromycin delivery system with high bioavailability for children and elder population.
Article
Multidisciplinary Sciences
Ngoc Yen Nguyen, Thi Ngoc Phuong Nguyen, Nguyen Ngoc Huyen, Van De Tran, Tran Thi Bich Quyen, Huynh Vu Thanh Luong, Duy Toan Pham
Summary: This study compared the characteristics and capacity to generate micro-/nanoparticles of fibroin extracted from Thai silk and Vietnamese silk. The structure of Thai fibroin revealed less heavy chains, more light chains and P-25 glycoproteins, and lower crystallinity than those of Vietnamese fibroin. The particles formed by Vietnamese fibroin were significantly bigger, had lower drug entrapment efficiency, higher hemotoxicity, and less biostability in the blood compared to the particles formed by Thai fibroin.
Article
Pharmacology & Pharmacy
Suchiwa Pan-On, Sutisa Nudmamud-Thanoi, Ittipon Phoungpetchara, Waree Tiyaboonchai
Summary: This study assessed the effectiveness and safety of various nanocarriers for delivering curcumin in a Dex-induced depression rat model. The results showed that curcumin nanocarriers had an antidepressant-like effect on the depressive rats, reducing depression symptoms and protecting hippocampal and liver cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Van De Tran, Thi My Loan Vo, Khanh Nguyen Di, Quang Loc Duyen Vo, Rebecca Susan Dewey, Trung Tin Pham, Ba Kien Tran, Duy Toan Pham
Summary: This study investigated the job satisfaction of hospital pharmacists in Vinh Long province, Vietnam, and identified factors such as working conditions and leadership styles that significantly influenced job satisfaction. The majority of hospital pharmacists were satisfied with their job, but improvements to working conditions are needed.
Article
Biotechnology & Applied Microbiology
Nguyen Minh Thai, Ton That Huu Dat, Nguyen Thi Thanh Hai, Thanh Q. Bui, Nguyen Vinh Phu, Phan Tu Quy, Nguyen Thanh Triet, Duy Toan Pham, Van De Tran, Nguyen Thi Ai Nhung
Summary: Laboratory experiments were conducted to identify the chemical composition of Cordyceps militaris and provide evidence of its potential effects on Alzheimer's disease. Analysis revealed 21 bioactive compounds, with cordycepin content quantified at 0.32%. Bioassays demonstrated the extract's anti-Alzheimer potential. Computational predictions highlighted specific compounds as effective inhibitors and brain-penetrating agents.
Article
Pharmacology & Pharmacy
Minh Hoang Le, Huyen Sanh Sam, Duy Toan Pham, Ngoc Chi Lan Nguyen, Ngoc Diem Le, Tran Nhat Phong Dao
Summary: This study assessed the hypoglycemic effects of NVTK decoction, a traditional Vietnamese medicine, in a rat model of type-2 diabetes. The results showed that NVTK decoction improved diabetes symptoms, decreased insulin resistance, and had positive effects on pancreatic mass and blood lipid levels. The hypoglycemic effects of NVTK were comparable to those of gliclazide.
Article
Chemistry, Analytical
Anh Tuan Nguyen, Hung Cuong Nguyen, Dang Tien Nguyen, Quoc Cuong Huynh, Minh Hoang Le, Hoang Thuc Huynh, Duy Toan Pham
Summary: Recently, a new type of synthetic marijuana called American grass (Co My in Vietnamese) has been increasingly used in criminal and law-breaking actions in Vietnam. This study extracted, isolated, and analyzed the synthetic cannabinoid 5-Fluoro-MDMB-PICA from American grass samples for the first time. The developed GC/MS quantification method showed high specificity, linearity, accuracy, and precision, and the average concentration of 5-Fluoro-MDMB-PICA in the samples was 2.2% w/w.
Article
Health Care Sciences & Services
Ba Kien Tran, Thi Huong Vu, Duy Toan Pham, Duyen Thi My Huynh, Van De Tran
Summary: This study aimed to determine the factors affecting the satisfaction of pharmacy college alumni on training quality in Vietnam. A cross-sectional research using purposive sampling method was conducted on recent graduates of a pharmacy college. The study identified four factors influencing alumni satisfaction on training quality: training staff, facilities and environmental qualities, training programmes, and administrative formalities and support activities. To enhance training quality and alumni satisfaction, educational institutions should focus on innovating teaching methods and organizing training sessions and practical visits.
JOURNAL OF PHARMACEUTICAL HEALTH SERVICES RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Thieu Quang Quoc Viet, Huynh Phuoc Thanh, Do Minh Khoi, Tran Thi Kieu Trinh, Ngo Nguyen Tra My, Toan Duy Pham, Luong Huynh Vu Thanh, Phuong Lan Tran-Nguyen, Tran Thi Bich Quyen
Summary: In this study, a novel material, AuPt/graphene quantum dots nanocomposites (AuPt/GQDs NCPs), that have unique optical properties were successfully synthesized. The simple seed-growth method was used to synthesize Au nanoparticles (Au NPs), and these nanoparticles were combined with Pt to form AuPt nanodendrites, which have a unique core-shell structure. AuPt/GQDs NCPs were analyzed for morphology, properties, and composition using various techniques, and tested for glucose detection by photoluminescence (PL) spectroscopy. The results showed the potential of the synthesized material for glucose detection, as well as its application in the diagnosis and early detection of dangerous diseases using luminescence spectroscopy.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Health Care Sciences & Services
Van De Tran, Ba Kien Tran, Duyen Thi My Huynh, Thanh Yen Nguyen, Thi My Thao Nguyen, Thi My Tien Pham, Quang Loc Duyen Vo, Valeria Valeryevna Dorofeeva, Rebecca Susan Dewey, Duy Toan Pham
Summary: This study investigated the motivations and barriers to pharmacists implementing telepharmacy in the Mekong Delta region, Vietnam. Results showed that having a pharmacy degree and a higher income were positively associated with telepharmacy use. The main motivation was providing healthcare services to remote areas, while the main barrier was the lack of policies and regulations. A majority of pharmacists without telepharmacy experience expressed a desire to use it in the future. The Vietnamese government needs to issue detailed regulations to support the advancement of telepharmacy in the country.
JOURNAL OF PHARMACEUTICAL HEALTH SERVICES RESEARCH
(2023)
Article
Health Care Sciences & Services
Khanh Nguyen Di, Sun Tee Tay, Sasheela Sri La Sri Ponnampalavanar, Duy Toan Pham, Li Ping Wong
Summary: This study examines the perspectives of physicians in Vietnam on the factors influencing antibiotic resistance (ABR), focusing on knowledge deficiency, antibiotic prescribing practice, and regulations and policies. The findings reveal weaknesses in current antibiotic prescribing strategies and management policies, providing valuable information for policymakers in combating ABR in Vietnam.
Article
Pharmacology & Pharmacy
Van De Tran, Trung Kien Nguyen, Rebecca Susan Dewey, Minh Hoang Le, Duy Toan Pham
Summary: A study in Vietnam found that pharmacy students had higher levels of depression, anxiety, and psychological distress compared to students in other healthcare-related disciplines during the COVID-19 pandemic. It is important to recognize and provide early intervention for mental health problems, especially anxiety, among pharmacy students.
JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
(2023)
