Article
Cell Biology
Jincheng Liu, Zhenqian Sun, Yunhao You, Lu Zhang, Dehui Hou, Guanghui Gu, Yunzhen Chen, Guangjun Jiao
Summary: In this study, it was found that macrophage-derived exosomal miR-486-5p influences the differentiation potential of BMMSCs and osteoporosis through the miR-486-5p/SMAD2/TGF-beta signaling pathway.
Article
Medicine, Research & Experimental
Fatemeh Sokouti Nasimi, Saber Zahri, Shahin Ahmadian, Afsaneh Bagherzadeh, Nahideh Nazdikbin Yamchi, Leila Haghighi, Alberto Miranda Bedate, Balal Khalilzadeh, Reza Rahbarghazi, Mahdi Mahdipour
Summary: The study showed that estradiol can increase the viability of mouse SSCs in a dose-dependent manner, leading to changes in cell morphology and gene expression, as well as reduced sperm parameters and testicular progenitor cells. This suggests that estradiol may induce Sertoli cell differentiation of SSCs while long-term exogenous administration can lead to infertility.
Article
Biochemistry & Molecular Biology
Chen-Yuan Kao, Jinlin Jiang, Will Thompson, Eleftherios T. Papoutsakis
Summary: Megakaryocyte-derived submicron size microparticles (MkMPs) induce the megakaryocytic differentiation of hematopoietic stem/progenitor cells (HSPCs) through the combined effects of miR-486-5p and miR-22-3p, as well as through JNK and PI3K/Akt/mTOR signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Massimo Moro, Orazio Fortunato, Giulia Bertolini, Mavis Mensah, Cristina Borzi, Giovanni Centonze, Francesca Andriani, Daniela Di Paolo, Patrizia Perri, Mirco Ponzoni, Ugo Pastorino, Gabriella Sozzi, Mattia Boeri
Summary: Despite improvements in therapies and screening strategies, lung cancer prognosis remains poor, especially for patients with metastatic tumors. Cancer stem cells (CSCs) are a major cause of the low survival rate, and microRNA miR-486-5p has been identified as a potential therapeutic target for lung cancer.
Article
Endocrinology & Metabolism
Maryam Khanehzad, Seyed Mehdi Nourashrafeddin, Farid Abolhassani, Shokoofeh Kazemzadeh, Soheila Madadi, Elham Shiri, Parastoo Khanlari, Zahra Khosravizadeh, Azim Hedayatpour
Summary: The study found that inhibition of miRNA-30a-5p promotes differentiation and reduces proliferation markers expression in SSCs. This provides new clues for understanding the role of miRNAs in fate determinations of SSCs.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Reproductive Biology
Bin Wang, Chengxi Zhai, Yingzhong Li, Bo Ma, Zhu Li, Jian Wang
Summary: This study reveals that extracellular vesicles (EVs) derived from Sertoli cells (SCs) can transport miR-30a-5p to regulate the proliferation and differentiation of spermatogonial stem cells (SSCs). The findings shed light on the importance of intercellular communication mechanisms and molecular regulatory networks in the treatment of male infertility.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Oncology
Xian-Ming Lin, Zhi-Jiang Wang, Yu-Xiao Lin, Hao Chen
Summary: The study aimed to investigate the preliminary mechanism underlying the peritoneal metastasis of gastric cancer cells by extraction and analysis of exosomes. Results showed that PM-Exo had a more significant effect on cell expression and morphology compared to Con-Exo. Downregulation of miR-486-5p via exosomes may be responsible for gastric cancer cell peritoneal metastasis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinlian Liang, Hanhao Li, Jiaxin Mei, Zhen Cao, Yan Tang, Rufei Huang, Huan Xia, Qihao Zhang, Qi Xiang, Yan Yang, Yadong Huang
Summary: The study revealed that SC-derived miR-145-5p plays a significant role in regulating the functions of Leydig cells and may serve as a diagnostic biomarker for male hypogonadism developmental abnormalities during puberty.
Article
Nanoscience & Nanotechnology
Honghao Yu, Yiping Wu, Boyu Zhang, Mingchen Xiong, Yi Yi, Qi Zhang, Min Wu
Summary: This study demonstrated that E2F1-deficient ADSC-Exos promote wound healing by enhancing collagen formation and angiogenesis, and by regulating miRNA to enhance fibroblast activities. This finding provides a novel strategy of gene-engineered stem cell exosomes for accelerating wound healing.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Oncology
Chen Lin, Yingying Yang, Yingxue Wang, Heng Jing, Xinyi Bai, Zheng Hong, Chunxiang Zhang, Hui Gao, Linkun Zhang
Summary: Studies have shown that exosomes containing miRNAs from the aseptic inflammatory microenvironment play a crucial role in bone remodeling, but the mechanism affecting the osteogenic ability of PDLSCs remains unclear. This study demonstrated that exosomes derived from periodontal ligament fibroblasts, induced by PGE(2), inhibit osteogenic differentiation of PDLSCs through the miR-34c-5p/SATB2/ERK pathway.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hui Hu, Xiaowei Hu, Lin Li, Yan Fang, Yan Yang, Jingjing Gu, Jiadong Xu, Lisheng Chu
Summary: Exosomes derived from bone mesenchymal stem cells (BMSC-Exos) can promote angiogenesis and improve neurological functions in ischemic stroke mice via upregulation of miR-21-5p. In vitro experiments show that BMSC-Exos also enhance the functions of human umbilical vein endothelial cells (HUVECs).
Article
Oncology
Huijie Gao, Zhaobin He, Chao Gao, Naiqing Liu, Zhaoyang Zhang, Weibo Niu, Jun Niu, Cheng Peng
Summary: This study identified exosome-encapsulated miR-3124-5p as a promoter of the malignant progression of cholangiocarcinoma by targeting GDF11. Exosomal miR-3124-5p and GDF11 could potentially serve as biomarkers or therapeutic targets for cholangiocarcinoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Environmental Sciences
Zongqiang Hu, Yingpeng Zhao, Jie Jiang, Wang Li, Gang Su, Li Li, Jianghua Ran
Summary: This study investigates the effect of liver stem cells (LSCs)-derived exosomes and the miR-142a-5p carried by them on fibrosis by regulating macrophage polarization. The findings suggest that LSCs-EVs regulate macrophage polarization and improve the progression of liver fibrosis through the miR-142a-5p/ctsb pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Moises N. Segunda, Carlos Diaz, Cristian G. Torres, Victor H. Parraguez, Monica de los Reyes, Oscar A. Peralta
Summary: The study compared the potential of peripheral blood-derived mesenchymal stem cells (PB-MSC) and spermatogonial stem cells (SSC) in producing germ cells (GC) in a three-dimensional co-culture system with Sertoli cells (SC). The results showed that SSC exhibited a more robust GC differentiation profile compared to PB-MSC in the 3D co-culture with SC.
Article
Endocrinology & Metabolism
Ziyi Li, Chang Liu, Shilun Li, Ting Li, Yukun Li, Na Wang, Xiaoxue Bao, Peng Xue, Sijing Liu
Summary: The study revealed that BMSC-derived exosomes attenuate dexamethasone-induced muscle atrophy by upregulating miR-486-5p and inhibiting nuclear translocation of FoxO1. These results suggest that BMSC-Exos have a protective effect on muscles and can inhibit muscle atrophy through the miR486-5p/Foxo1 axis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Yan Yang, Qilian Lin, Chengxing Zhou, Quan Li, Ziyi Li, Zhen Cao, Jinlian Liang, Hanhao Li, Jiaxin Mei, Qihao Zhang, Qi Xiang, Wei Xue, Yadong Huang
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Cell & Tissue Engineering
Yan Yang, Chenxing Zhou, Tiantian Zhang, Quan Li, Jiaxin Mei, Jinlian Liang, Ziyi Li, Hanhao Li, Qi Xiang, Qihao Zhang, Lei Zhang, Yadong Huang
Article
Biochemistry & Molecular Biology
Jinlian Liang, Hanhao Li, Jiaxin Mei, Zhen Cao, Yan Tang, Rufei Huang, Huan Xia, Qihao Zhang, Qi Xiang, Yan Yang, Yadong Huang
Summary: The study revealed that SC-derived miR-145-5p plays a significant role in regulating the functions of Leydig cells and may serve as a diagnostic biomarker for male hypogonadism developmental abnormalities during puberty.
Article
Computer Science, Artificial Intelligence
Dongxiang Zhang, Zepeng Li, Xiaoli Wang, Kian-Lee Tan, Gang Chen
Summary: This paper examines the task of entity resolution from a broader perspective, expanding its input from textual records to other modalities and proposing a unified model to support various applications. By fully exploiting the semantic contexts of embedding vectors, an integrated multi-context attention framework is proposed. Extensive experiments verify the effectiveness and generality of the model.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2022)
Article
Biology
Jinlian Liang, Yan Tang, Hanhao Li, Jiaxin Mei, Zhen Cao, Huan Xia, Rufei Huang, Yan Yang, Yadong Huang
Summary: In this study, an improved protocol for isolating primary Leydig cells from testicular tissue by digestion with collagenase IV is described. This method overcomes drawbacks of available methods, such as the need for sophisticated instruments, high cost, tediousness, and time consumption.