Astragaloside IV alleviates PM2.5-induced lung injury in rats by modulating TLR4/MyD88/NF-κB signalling pathway

A novel inhibitory role of microRNA‐224 in particulate matter 2.5‐induced asthmatic mice by inhibiting TLR2

(2020) Ping Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibitory functions of maslinic acid on particulate matter-induced lung injury through TLR4-mTOR-autophagy pathways

(2020) So Yeon Jeong et al.   ENVIRONMENTAL RESEARCH

MicroRNA‑93 contributes to the suppression of lung inflammatory responses in LPS‑induced acute lung injury in mice via the TLR4/MyD88/NF‑κB signaling pathway

(2020) Hu Gao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Dapk1 improves inflammation, oxidative stress and autophagy in LPS-induced acute lung injury via p38MAPK/NF-κB signaling pathway

(2020) Tao Li et al.   MOLECULAR IMMUNOLOGY

BMSC-derived exosomes alleviate smoke inhalation lung injury through blockade of the HMGB1/NF-κB pathway

(2020) Bin Xu et al.   LIFE SCIENCES

Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR

(2019) Bin Leng et al.   MEDIATORS OF INFLAMMATION

PM2.5 promotes plaque vulnerability at different stages of atherosclerosis and the formation of foam cells via TLR4/MyD88/NFκB pathway

(2019) Jin Geng et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Astragaloside IV alleviates doxorubicin induced cardiomyopathy by inhibiting NADPH oxidase derived oxidative stress

(2019) Jiamao Lin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of Rac1 activity alleviates PM2.5-induced pulmonary inflammation via the AKT signaling pathway

(2019) Shuijuan Zhang et al.   TOXICOLOGY LETTERS

Effects of Astragaloside IV on treatment of breast cancer cells execute possibly through regulation of Nrf2 via PI3K/AKT/mTOR signaling pathway

(2019) Xiao‐Qing Zhang et al.   Food Science & Nutrition

Astragaloside IV ameliorates motor deficits and dopaminergic neuron degeneration via inhibiting neuroinflammation and oxidative stress in a Parkinson's disease mouse model

(2019) Cong Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Astragaloside-IV protects H9C2(2-1) cardiomyocytes from high glucose-induced injury via miR-34a-mediated autophagy pathway

(2019) Yaobin Zhu et al.   Artificial Cells Nanomedicine and Biotechnology

Ma Xing Shi Gan Decoction Attenuates PM2.5 Induced Lung Injury via Inhibiting HMGB1/TLR4/NFκB Signal Pathway in Rat

(2019) Yu-xiang Fei et al.   Frontiers in Pharmacology

Astragaloside IV attenuates sepsis-induced intestinal barrier dysfunction via suppressing RhoA/NLRP3 inflammasome signaling

(2019) Shuhua Xie et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Astragaloside IV ameliorates neuroinflammation-induced depressive-like behaviors in mice via the PPARγ/NF-κB/NLRP3 inflammasome axis

(2018) Mei-ting Song et al.   ACTA PHARMACOLOGICA SINICA

Astragaloside IV Inhibits Cigarette Smoke-Induced Pulmonary Inflammation in Mice

(2018) Zhou Meiqian et al.   INFLAMMATION

YiQiFuMai lyophilized injection attenuates particulate matter-induced acute lung injury in mice via TLR4-mTOR-autophagy pathway

(2018) Yuanli Xia et al.   BIOMEDICINE & PHARMACOTHERAPY

Glycyrrhizin inactivates toll-like receptor (TLR) signaling pathway to reduce lipopolysaccharide-induced acute lung injury by inhibiting TLR2

(2018) Delei Kong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Protective effects of Astragaloside IV on endoplasmic reticulum stress-induced renal tubular epithelial cells apoptosis in type 2 diabetic nephropathy rats

(2018) Yinghui Ju et al.   BIOMEDICINE & PHARMACOTHERAPY

Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Daniel Dicker et al.   LANCET

Air particulate matter induced oxidative stress and inflammation in cardiovascular disease and atherosclerosis: The role of Nrf2 and AhR-mediated pathways

(2017) Akeem O. Lawal   TOXICOLOGY LETTERS

Metabolomics analysis reveals that benzo[a]pyrene, a component of PM 2.5 , promotes pulmonary injury by modifying lipid metabolism in a phospholipase A2-dependent manner in vivo and in vitro

(2017) Song-Yang Zhang et al.   Redox Biology

Astragaloside IV ameliorates 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis implicating regulation of energy metabolism

(2017) Xu-Guang Jiang et al.   Scientific Reports

Acute Lung Injury: A Clinical and Molecular Review

(2016) Yasmeen Butt et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Pretreatment with Astragaloside IV protects human umbilical vein endothelial cells from hydrogen peroxide induced oxidative stress and cell dysfunction via inhibiting eNOS uncoupling and NADPH oxidase – ROS – NF-κB pathway

(2016) Chonghua Xu et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Dexamethasone Attenuates LPS-induced Acute Lung Injury through Inhibition of NF-κB, COX-2, and Pro-inflammatory Mediators

(2016) Naif O. Al-Harbi et al.   IMMUNOLOGICAL INVESTIGATIONS

Protective effect of Astragaloside IV against sepsis-induced acute lung injury in rats

(2016) Ruiqin Huang et al.   SAUDI PHARMACEUTICAL JOURNAL

Autophagy is essential for ultrafine particle-induced inflammation and mucus hyperproduction in airway epithelium

(2015) Zhi-Hua Chen et al.   Autophagy

Protective Effect of Astragaloside IV Against Paraquat-Induced Lung Injury in Mice by Suppressing Rho Signaling

(2015) Tong Chen et al.   INFLAMMATION

Astragaloside IV Inhibits NF-κB Activation and Inflammatory Gene Expression in LPS-Treated Mice

(2015) Wei-Jian Zhang et al.   MEDIATORS OF INFLAMMATION

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Astragaloside IV attenuates glycated albumin-induced epithelial-to-mesenchymal transition by inhibiting oxidative stress in renal proximal tubular cells

(2013) Weiwei Qi et al.   CELL STRESS & CHAPERONES

Pulmonary Macrophage Subpopulations in the Induction and Resolution of Acute Lung Injury

(2012) Laura K. Johnston et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases

(2012) I-Ta Lee et al.   BIOCHEMICAL PHARMACOLOGY

NOX enzymes: potential target for the treatment of acute lung injury

(2012) Stéphanie Carnesecchi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice

(2011) D.R. Riva et al.   INHALATION TOXICOLOGY

Unknown

(2011) Jochen Grommes et al.   MOLECULAR MEDICINE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY