Article
Plant Sciences
Rentsen Badamjav, Lu Zhang, Dolgor Sonom, Yun-Hao Wu, Jun-Ping Kou, Bo-Yang Yu, Fang Li
Summary: Thalictrum minus L., a traditional Mongolian folk medicinal plant, demonstrates effectiveness in attenuating particulate matter-induced acute lung injury by modulating inflammatory cytokines and oxidative damage signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Environmental Sciences
Amanda Garcia, Eduarda Santa-Helena, Anna De Falco, Joaquim de Paula Ribeiro, Adriana Gioda, Carolina Rosa Gioda
Summary: This review examined the toxic effects of PM2.5 particles on human health from 2016 to 2021, finding an increased risk of cardiovascular and respiratory diseases, as well as a correlation with higher morbidity and mortality rates. The study also assessed the interaction between PM2.5 and COVID-19/Sars-CoV-2.
WATER AIR AND SOIL POLLUTION
(2023)
Article
Multidisciplinary Sciences
Huasong Bai, Ying Wang, Peng Wu, Zhanzhong Wang
Summary: This study investigated the cellular injury in cat lung cells exposed to APM extracts, and found that VE, lycopene, and EPA: DHA can alleviate the damage. Treatment with EPA: DHA also increased antioxidant enzyme activities and decreased oxidative stress indices.
Article
Immunology
Li Liu, Qiangqiang Shi, Kankai Wang, Yao Qian, Liqin Zhou, Saverio Bellusci, Chengshui Chen, Nian Dong
Summary: FGF10 protects against PM-induced lung injury by activating the PI3K/Akt/Nrf2 pathway, thereby alleviating oxidative damage and pyroptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Chieh-Mo Lin, Tzu-Hsiung Huang, Miao-Chig Chi, Su-Er Guo, Chiang-Wen Lee, Su-Lun Hwang, Chung-Sheng Shi
Summary: This study found that PM2.5-induced lung injury is caused by oxidative stress leading to the recruitment of neutrophils and Ly6C(high) monocytes, and production of inflammatory proteins. Treatment with NAC alleviated PM2.5 induced lung injury by attenuating the ROS-mediated recruitment of neutrophils and Ly6C(high) monocytes and lung inflammation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Jeonghoon Han, Yeun Park, Hyeryeong Jeong, Jun Chul Park
Summary: PM2.5 has significant effects on the life history traits, oxidative stress levels, and detoxification-related genes of Tigriopus japonicus.
MARINE POLLUTION BULLETIN
(2022)
Article
Environmental Sciences
Thavin Kumar Mathana Sundram, Eugenie Sin Sing Tan, Shiau Chuen Cheah, Hwee San Lim, Marjan Sadat Seghayat, Normina Ahmad Bustami, Chung Keat Tan
Summary: This study investigated the impact of PM2.5 concentration on the respiratory health of outdoor workers in Malaysia. The findings showed that changes in PM2.5 concentration were significantly associated with eye symptoms, nasal symptoms, and respiratory questionnaire results, but not with asthma control. Outdoor workers were more affected by changes in PM2.5 compared to indoor workers.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Physiology
Fei Qin, Zhengzheng Fan, Minxiao Xu, Zhongwei Wang, Yanan Dong, Chaoyi Qu, Shuqiang Cui, Lina Zhao, Jiexiu Zhao
Summary: The study demonstrated that aerobic exercise can alleviate lung injury induced by PM2.5, potentially through downregulation of p38-MAPK and inhibition of COX-2 and PGE(2) pathways.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Toxicology
Junling Gao, Tong Lei, Hongyun Wang, Kai Luo, Yuanli Wang, Bingqing Cui, Zhuoran Yu, Xiaoqi Hu, Fang Zhang, Yingjie Chen, Wenjun Ding, Zhongbing Lu
Summary: This study found that DDAH1 has a protective effect on long-term PM2.5 exposure-induced lung injury, reducing oxidative stress and inflammation. DDAH1 overexpression can reverse the effects of PM2.5 on lung-related proteins. Exogenous administration of ADMA exacerbates the inflammatory response and oxidative stress in PM2.5-exposed macrophages.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Engineering, Environmental
Sujeong Park, Miji Kim, Minkyung Park, Yang Jin, Seon-Jin Lee, Heedoo Lee
Summary: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe inflammatory diseases characterized by the destruction of lung tissue and the upregulation of specific miRNAs, such as miR-6238. This study found that miR-6238 is specifically upregulated in response to particulate matter (PM) exposure but not bacterial endotoxin (LPS/PTG), and it plays a role in regulating inflammatory responses in alveolar macrophages (AMs). These findings suggest that miR-6238 could serve as a biomarker to distinguish PM-induced ALI from endotoxin-mediated ALI.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Ching-Huang Lai, Shu-Chuan Ho, Chih-Hong Pan, Wei-Liang Chen, Chung-Ching Wang, Che-Wi Liang, Chi-Yu Chien, Michael Riediker, Kai-Jen Chuang, Hsiao-Chi Chuang
Summary: Chronic exposure to metal fume PM2.5 was associated with oxidative stress and inflammation in shipyard workers. Urinary metal concentrations were significantly correlated with metabolites in urine.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Hui Chen, David Van Reyk, Annabel Oliveira, Yik Lung Chan, Stephanie E. L. Town, Benjamin Rayner, Carol A. Pollock, Sonia Saad, Jacob George, Matthew P. Padula, Brian G. Oliver
Summary: Maternal exposure to low levels of PM2.5 has negative effects on liver health and metabolism in offspring, with more severe impacts on females. Removing PM2.5 during gestation provides limited protection in offspring's metabolism.
Article
Chemistry, Medicinal
Yilan Wang, Sijing Zhao, Nan Jia, Zherui Shen, Demei Huang, Xiaomin Wang, Yongcan Wu, Caixia Pei, Shihua Shi, Yacong He, Zhenxing Wang
Summary: This study found that rosavin can prevent PM2.5-induced lung injury and suppress ferroptosis by upregulating the PI3K/Akt/Nrf2 signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Bowen Yin, Jingyi Ren, Qiqi Cui, Xuanyi Liu, Ziyi Wang, Huanting Pei, Jinshi Zuo, Yadong Zhang, Rui Wen, Xiaoya Sun, Weican Zhang, Yuxia Ma
Summary: ASX preconditioning can alleviate lung injury after PM2.5 exposure by inhibiting ferroptosis and apoptosis.
Article
Engineering, Environmental
Simin Wang, Qixing Zhou, Yingze Tian, Xiangang Hu
Summary: This study demonstrates a close correlation between alterations in the pulmonary microbiota and pulmonary inflammation and oxidative stress caused by PM2.5 exposure. Transfer of the microbiota and antibiotic intervention can affect the severity of pulmonary inflammation and oxidative stress. These results reveal the important role of the pulmonary microbiota.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Samuel S. Valenca, Brittany E. Dong, Elizabeth M. Gordon, Ramon C. Sun, Christopher M. Waters
Summary: This study reveals the crucial role of ASK1 in bleomycin-induced pulmonary fibrosis in mice, mediated through the p38 and ERK1/2 signaling pathways. Inhibition of ASK1 can attenuate the progression of fibrosis and improve relevant indicators and histological parameters.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Environmental Sciences
Sidney Fernandes Sales Junior, Evelyn Oliveira da Silva, Gabriel de Farias Araujo, Lorena Oliveira Souza Soares, Claudio Ernesto Taveira Parente, Olaf Malm, Enrico Mendes Saggioro, Fabio Verissimo Correia
Summary: Long-term exposure of Eisenia andrei earthworms to fluoroquinolone-contaminated poultry litter led to increased CAT and SOD activities, as well as dose-dependent responses in GST and GSH levels. However, lipid peroxidation levels showed a decreasing trend. These findings suggest a trend of antioxidant system attenuation in response to successive poultry litter applications, with major alterations observed in the first month of exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Medicinal
Helber da Maia Valenca, Cyntia Pecli Silva, Lycia Brito Gitirana, Samuel Santos Valenca, Manuella Lanzetti
Summary: The study found that Ilex paraguariensis can prevent the development of metabolic disorders caused by obesity by reducing oxidative stress and inflammation, protecting the liver and adipose tissue, and regulating the levels of metabolic markers.
PHYTOTHERAPY RESEARCH
(2022)
Article
Environmental Sciences
Leandro de Oliveira Drummond, Rodrigo Ornellas Meire, Caryne Braga, Carlos Eduardo de Rezende, Olaf Malm, Rui Cerqueira
Summary: This study investigated the influence of altitudinal distribution, size, trophic position, and degree of water dependence on mercury concentration in amphibians in a mountainous complex in southeastern Brazil. The results showed a positive relationship between elevation and mercury concentration in topsoil samples from rainforest sites, while samples from cloud forest and highland grasslands had lower mercury concentration than expected. This suggests that vegetation structure plays a key role in the deposition of atmospheric mercury, and various factors such as elevation, trophic level, and water dependence affect mercury concentration in amphibians.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Jose E. Celis, Winfred Espejo, Janeide de A. Padilha, Karen A. Kidd, Rodrigo Goncalves, Paulo Dorneles, Douglas Oliveira, Olaf Malm, Christopher A. Celis, Gustavo Chiang
Summary: Trace metals bioaccumulate and some biomagnify in aquatic organisms, posing a threat to organisms and human consumers. This study investigated the trophodynamics of trace metals in aquatic food webs from remote coastal zones in the southern hemisphere, revealing the influence of geographic location and species on the fate of these metals.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biodiversity Conservation
Douglas William Cirino, Leandro Reverberi Tambosi, Thais Mauad, Simone Rodrigues de Freitas, Jean Paul Metzger
Summary: The spatial distribution and type of green areas have different effects on human health. Land sharing configuration is beneficial for preventing cardiovascular diseases, while land sparing and arboreal vegetation are relevant to reduce hospitalizations by lower respiratory diseases. Forests, on the other hand, are associated with increased rates of hospitalization by respiratory allergies causes. Therefore, a balanced distribution of green areas in urban spaces can create healthier environments.
JOURNAL OF APPLIED ECOLOGY
(2022)
Article
Environmental Sciences
G. P. Bighetti, J. A. Padilha, L. S. T. Cunha, O. Malm, P. L. Mancini
Summary: Seabird feathers are important matrices for analyzing environmental contaminants. In this study on brown boobies, the concentration of total mercury (THg) was measured in different types of feathers, revealing higher levels in ventral and wing feathers compared to dorsal and tail feathers. Juvenile birds had lower concentrations of THg in all feather types compared to adults. Ventral feathers are suggested as the most suitable biomonitor for THg contamination in brown boobies, but further studies are needed for other tropical seabird species.
Article
Biochemistry & Molecular Biology
Alexsandro Tavares Figueiredo-Junior, Samuel Santos Valenca, Priscilla Vanessa Finotelli, Francisca de Fatima dos Anjos, Lycia de Brito-Gitirana, Christina Maeda Takiya, Manuella Lanzetti
Summary: The therapeutic use of annatto pigments has been evaluated in animal models, with beneficial effects attributed to the inhibition of oxidative stress. Bixin nanoparticles were prepared and found to prevent pulmonary inflammation and oxidative stress induced by cigarette smoke.
Article
Biochemistry & Molecular Biology
Bianca C. de S. Ribeiro, Regina V. de C. Faria, Jeane de S. Nogueira, Samuel Santos Valenca, Lin Chen, Bruna Romana-Souza
Summary: Olive oil promotes skin wound healing by activating the Nrf2 pathway, which enhances cell survival and migration in fibroblasts. This is achieved through the production of reactive oxygen and nitrogen species, as well as the activation of specific proteins. The findings suggest that olive oil has potential therapeutic applications in wound healing.
Article
Biochemistry & Molecular Biology
Piotr Sklepkiewicz, Barbara Dymek, Michal Mlacki, Agnieszka Zagozdzon, Magdalena Salamon, Anna Maria Siwinska, Marcin Piotr Mazurkiewicz, Natalia de Souza Xavier Costa, Marzena Mazur, Thais Mauad, Adam Golebiowski, Karolina Dzwonek, Jakub Golab, Zbigniew Zaslona
Summary: Chitotriosidase (CHIT1) is an enzyme that regulates macrophages and their role in asthma development was investigated. The expression of CHIT1 was examined in lung tissues of individuals with severe, uncontrolled, steroid-naive asthma, and a chitinase inhibitor called OATD-01 was tested in a mouse model of chronic asthma. The results showed that inhibiting CHIT1 had beneficial effects, reducing inflammation and airway remodeling in asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Camila Oliveira da Silva, Jeane de Souza Nogueira, Adriana Paulino do Nascimento, Tatiana Victoni, Thiago Prudente Bartholo, Claudia Henrique da Costa, Andrea Monte Alto Costa, Samuel dos Santos Valenca, Martina Schmidt, Luis Cristovao Porto
Summary: COPD is a major contributor to morbidity and mortality worldwide, characterized by airflow limitation and diverse clinical features. The study identified genetic changes associated with COPD phenotypes and severity, as well as a higher prevalence of M2 markers. The findings have implications for future treatments and personalized therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Lindsey R. Conroy, Harrison A. Clarke, Derek B. Allison, Samuel Santos Valenca, Qi Sun, Tara R. Hawkinson, Lyndsay E. A. Young, Juanita E. Ferreira, Autumn V. Hammonds, Jaclyn B. Dunne, Robert J. McDonald, Kimberly J. Absher, Brittany E. Dong, Ronald C. Bruntz, Kia H. Markussen, Jelena A. Juras, Warren J. Alilain, Jinze Liu, Matthew S. Gentry, Peggi M. Angel, Christopher M. Waters, Ramon C. Sun
Summary: Spatial metabolomics was used to analyze the location and chemistry of small molecules in fibrotic lungs. A bioinformatic pipeline was developed to identify actionable targets and assess tissue metabolic heterogeneity in human lung diseases. The findings suggest that lysosomal utilization of glycogen is required for pulmonary fibrosis progression.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Frank Silva Bezerra, Manuella Lanzetti, Renata Tiscoski Nesi, Akinori Cardozo Nagato, Cyntia Pecli e Silva, Emanuel Kennedy-Feitosa, Adriana Correa Melo, Isabella Cattani-Cavalieri, Luis Cristovao Porto, Samuel Santos Valenca
Summary: Acute and chronic lung injuries are major causes of global mortality. Current therapies primarily focus on symptom relief rather than reversing or preventing lung pathology. Supportive interventions, such as oxygen and mechanical ventilation, can worsen lung function and lead to permanent injuries. Sepsis, originating from extrapulmonary or respiratory sources, contributes to lung-related deaths. This article aims to summarize the molecular and cellular mechanisms of acute and chronic lung injuries, focusing on airway inflammation and oxidative stress. It also explores new antioxidant-based drug options for managing these conditions.
Article
Biochemistry & Molecular Biology
Maria Clara Barbosa-de-Oliveira, Paolo Oliveira-Melo, Marcos Henrique Goncalves da Silva, Flavio Santos da Silva, Felipe Andrade Carvalho da Silva, Bruno Vinicios Silva de Araujo, Moacir Franco de Oliveira, Aristides Tadeu Correia, Sidnei Miyoshi Sakamoto, Samuel Santos Valenca, Manuella Lanzetti, Martina Schmidt, Emanuel Kennedy-Feitosa
Summary: This study investigates the role of eugenol (EUG) in cigarette smoke-induced acute lung injury (ALI) and how it modulates macrophage activity. The results show that EUG reduces inflammatory response and oxidative stress markers in vivo, and balances oxidative stress and cytokine release in vitro, indicating that it acts as a modulator of macrophage activity.
Meeting Abstract
Biochemistry & Molecular Biology
Lindsey R. Conroy, Derek B. Allison, Samuel Santos Valenca, Qi Sun, Lyndsay E. A. Young, Harrison A. Clarke, Tara R. Hawkinson, Jaclyn B. Dunne, Robert J. McDonald, Brittany E. Dong, Ronald C. Bruntz, Kia H. Markussen, Warren J. Alilain, Matthew S. Gentry, Jinze Liu, Peggi M. Angel, Christopher M. Waters, Ramon C. Sun