The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis

Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient

(2020) Neil McCarthy et al.   Cell Stem Cell

Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling

(2020) Jiuzhi Xu et al.   EMBO JOURNAL

Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer

(2020) Hae-Ock Lee et al.   NATURE GENETICS

Immunotherapy in colorectal cancer: rationale, challenges and potential

(2019) Karuna Ganesh et al.   Nature Reviews Gastroenterology & Hepatology

Cancer-associated fibroblasts in gastrointestinal cancer

(2019) Hiroki Kobayashi et al.   Nature Reviews Gastroenterology & Hepatology

Hepatocytes direct the formation of a pro-metastatic niche in the liver

(2019) Jae W. Lee et al.   NATURE

Meflin-positive cancer-associated fibroblasts inhibit pancreatic carcinogenesis

(2019) Yasuyuki Mizutani et al.   CANCER RESEARCH

Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction

(2019) Akitoshi Hara et al.   CIRCULATION RESEARCH

GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients

(2019) Ulrike Neckmann et al.   Cell Communication and Signaling

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma

(2019) Kenta Kawasaki et al.   GASTROENTEROLOGY

Gene therapy comes of age

(2018) Cynthia E. Dunbar et al.   SCIENCE

The Dual Role of Bone Morphogenetic Proteins in Cancer

(2018) Duc-Hiep Bach et al.   Molecular Therapy-Oncolytics

Subepithelial telocytes are an important source of Wnts that supports intestinal crypts

(2018) Michal Shoshkes-Carmel et al.   NATURE

Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer

(2017) Barbara Jung et al.   GASTROENTEROLOGY

Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant

(2017) Lindsey A. George et al.   NEW ENGLAND JOURNAL OF MEDICINE

BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes

(2017) Zhen Qi et al.   Nature Communications

Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

(2016) Marco Gerling et al.   Nature Communications

Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential

(2015) Daniel L. Worthley et al.   CELL

Hedgehog Signaling Restrains Bladder Cancer Progression by Eliciting Stromal Production of Urothelial Differentiation Factors

(2014) Kunyoo Shin et al.   CANCER CELL

Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy

(2014) K. Yan et al.   GENES & DEVELOPMENT

BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation

(2014) Michael W. Pickup et al.   Molecular Oncology

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

(2014) Hayley Davis et al.   NATURE MEDICINE

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model

(2013) Leszek Lisowski et al.   NATURE

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL