Synthesis, Structural, and Conformational Analysis of 4′‐ C ‐Alkyl‐2′‐ O ‐Ethyl‐Uridine Modified Nucleosides

RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs

(2020) Sarah Bajan et al.   Cells

RNA-based pharmacotherapy for tumors: From bench to clinic and back

(2020) Xiangping Liang et al.   BIOMEDICINE & PHARMACOTHERAPY

Oligonucleotide Therapeutics as a New Class of Drugs for Malignant Brain Tumors: Targeting mRNAs, Regulatory RNAs, Mutations, Combinations, and Beyond

(2019) Anna M. Krichevsky et al.   Neurotherapeutics

Effect of Sugar 2′,4′-Modifications on Gene Silencing Activity of Small Interfering RNA Duplexes

(2019) Elise Malek-Adamian et al.   Nucleic Acid Therapeutics

Synthesis of 4′- C -aminoalkyl-2′- O -methyl modified RNA and their biological properties

(2018) Kana Koizumi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

RNA Structural Dynamics As Captured by Molecular Simulations: A Comprehensive Overview

(2018) Jiří Šponer et al.   CHEMICAL REVIEWS

Adjusting the Structure of 2′-Modified Nucleosides and Oligonucleotides via C4′-α-F or C4′-α-OMe Substitution: Synthesis and Conformational Analysis

(2018) Elise Malek-Adamian et al.   JOURNAL OF ORGANIC CHEMISTRY

Journey of siRNA: Clinical Developments and Targeted Delivery

(2018) Rahul R. Nikam et al.   Nucleic Acid Therapeutics

Synthesis and properties of 4′-C-aminoalkyl-2′-fluoro-modified RNA oligomers

(2018) Toshifumi Kano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Site-specific one-pot triple click labeling for DNA and RNA

(2018) Marie-Luise Winz et al.   CHEMICAL COMMUNICATIONS

Structural basis for the synergy of 4′- and 2′-modifications on siRNA nuclease resistance, thermal stability and RNAi activity

(2018) Joel M Harp et al.   NUCLEIC ACIDS RESEARCH

RNA therapy: Are we using the right molecules?

(2018) Ai-Ming Yu et al.   PHARMACOLOGY & THERAPEUTICS

Impact of modified ribose sugars on nucleic acid conformation and function

(2017) Marina Evich et al.   HETEROCYCLIC COMMUNICATIONS

Probing the Binding Interactions between Chemically Modified siRNAs and Human Argonaute 2 Using Microsecond Molecular Dynamics Simulations

(2017) S. Harikrishna et al.   Journal of Chemical Information and Modeling

4′-C-Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing

(2017) Elise Malek-Adamian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Accurately Modeling the Conformational Preferences of Nucleosides

(2017) Mihai Burai Patrascu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

Therapeutic nucleic acids: current clinical status

(2016) Kannan Sridharan et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Rigid 2′,4′-Difluororibonucleosides: Synthesis, Conformational Analysis, and Incorporation into Nascent RNA by HCV Polymerase

(2014) Saúl Martínez-Montero et al.   JOURNAL OF ORGANIC CHEMISTRY

The Free Energy Landscape of Pseudorotation in 3′–5′ and 2′–5′ Linked Nucleic Acids

(2014) Li Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Influence of 2′-Fluoro versus 2′-O-Methyl Substituent on the Sugar Puckering of 4′-C-Aminomethyluridine

(2013) Kiran R. Gore et al.   JOURNAL OF ORGANIC CHEMISTRY

The Conformationally Constrained N-Methanocarba-dT Analogue Adopts an Unexpected C4′-exo Sugar Pucker in the Structure of a DNA Hairpin

(2012) Pradeep S. Pallan et al.   BIOCHEMISTRY

Structure and nuclease resistance of 2′,4′-constrained 2′-O-methoxyethyl (cMOE) and 2′-O-ethyl (cEt) modified DNAs

(2012) Pradeep S. Pallan et al.   CHEMICAL COMMUNICATIONS

RNA-Based Therapeutics: Current Progress and Future Prospects

(2012) John C. Burnett et al.   CHEMISTRY & BIOLOGY

Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing

(2012) Glen F. Deleavey et al.   CHEMISTRY & BIOLOGY

Synthesis, Gene Silencing, and Molecular Modeling Studies of 4′-C-Aminomethyl-2′-O-methyl Modified Small Interfering RNAs

(2012) Kiran R. Gore et al.   JOURNAL OF ORGANIC CHEMISTRY

Novel Modifications in RNA

(2011) Kelly Phelps et al.   ACS Chemical Biology

Refinement of the Cornell et al. Nucleic Acids Force Field Based on Reference Quantum Chemical Calculations of Glycosidic Torsion Profiles

(2011) Marie Zgarbová et al.   Journal of Chemical Theory and Computation

Versatile Site-Specific Conjugation of Small Molecules to siRNA Using Click Chemistry

(2011) Takeshi Yamada et al.   JOURNAL OF ORGANIC CHEMISTRY

Chemical Modification of siRNA Bases To Probe and Enhance RNA Interference

(2011) Hayden Peacock et al.   JOURNAL OF ORGANIC CHEMISTRY

R.E.D. Server: a web service for deriving RESP and ESP charges and building force field libraries for new molecules and molecular fragments

(2011) Enguerran Vanquelef et al.   NUCLEIC ACIDS RESEARCH

Chemical Synthesis of Site-Specifically 2′-Azido-Modified RNA and Potential Applications for Bioconjugation and RNA Interference

(2010) Michaela Aigner et al.   CHEMBIOCHEM

Reparameterization of RNA χ Torsion Parameters for the AMBER Force Field and Comparison to NMR Spectra for Cytidine and Uridine

(2010) Ilyas Yildirim et al.   Journal of Chemical Theory and Computation

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Impact of Sugar Pucker on Base Pair and Mispair Stability

(2009) Adides A. Williams et al.   BIOCHEMISTRY

Exploring Chemical Modifications for siRNA Therapeutics: A Structural and Functional Outlook

(2009) Siddharth Shukla et al.   ChemMedChem

Chemically modified siRNA: tools and applications

(2008) J WATTS et al.   DRUG DISCOVERY TODAY

Conformationally restricted nucleotides as a probe of structure-function relationships in RNA

(2008) K. R. Julien et al.   RNA

Synthesis of 2′-O-modified adenosine building blocks and application for RNA interference

(2007) Dalibor Odadzic et al.   BIOORGANIC & MEDICINAL CHEMISTRY