Fucoxanthin inhibits lipopolysaccharide-induced inflammation and oxidative stress by activating nuclear factor E2-related factor 2 via the phosphatidylinositol 3-kinase/AKT pathway in macrophages

Health benefits of fucoxanthin in the prevention of chronic diseases

(2020) Minkyung Bae et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Fucoxanthin exerts anti-fibrogenic effects in hepatic stellate cells

(2019) Mi-Bo Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Luteolin-mediated PI3K/AKT/Nrf2 signaling pathway ameliorates inorganic mercury-induced cardiac injury

(2018) Ruiqi Baiyun et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Ligustilide attenuates vascular inflammation and activates Nrf2/HO-1 induction and, NO synthesis in HUVECs

(2018) Eun Sik Choi et al.   PHYTOMEDICINE

Lipid Extract of Nostoc commune var. sphaeroides Kützing, a Blue-Green Alga, Inhibits the Activation of Sterol Regulatory Element Binding Proteins in HepG2 Cells

(2018) Heather E. Rasmussen et al.   JOURNAL OF NUTRITION

Astaxanthin exerts anti-inflammatory and antioxidant effects in macrophages in NRF2-dependent and independent manners

(2018) Callie Farruggia et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

(2017) Tahir Ali et al.   MOLECULAR NEUROBIOLOGY

Resveratrol Attenuates the Cytotoxicity Induced by Amyloid-β1–42 in PC12 Cells by Upregulating Heme Oxygenase-1 via the PI3K/Akt/Nrf2 Pathway

(2017) Yang Hui et al.   NEUROCHEMICAL RESEARCH

Betulin exhibits anti-inflammatory activity in LPS-stimulated macrophages and endotoxin-shocked mice through an AMPK/AKT/Nrf2-dependent mechanism

(2017) Xinxin Ci et al.   Cell Death & Disease

Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy

(2016) Tian Qin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-Neuroinflammatory Effects of Fucoxanthin via Inhibition of Akt/NF-κB and MAPKs/AP-1 Pathways and Activation of PKA/CREB Pathway in Lipopolysaccharide-Activated BV-2 Microglial Cells

(2016) Dong Zhao et al.   NEUROCHEMICAL RESEARCH

Fucoxanthin Suppresses Lipid Accumulation and ROS Production During Differentiation in 3T3-L1 Adipocytes

(2016) Min-Jung Seo et al.   PHYTOTHERAPY RESEARCH

Association of Circulating Follistatin-Like 1 Levels with Inflammatory and Oxidative Stress Markers in Healthy Men

(2016) Satoko Hayakawa et al.   PLoS One

Agmatine Reduces Lipopolysaccharide-Mediated Oxidant Response via Activating PI3K/Akt Pathway and Up-Regulating Nrf2 and HO-1 Expression in Macrophages

(2016) Jianshen Chai et al.   PLoS One

The involvement of FAK-PI3K-AKT-Rac1 pathway in porcine reproductive and respiratory syndrome virus entry

(2015) Bo Ni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lico A Enhances Nrf2-Mediated Defense Mechanisms againstt-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 Cells

(2015) Hongming Lv et al.   Oxidative Medicine and Cellular Longevity

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Berry anthocyanins suppress the expression and secretion of proinflammatory mediators in macrophages by inhibiting nuclear translocation of NF-κB independent of NRF2-mediated mechanism

(2014) Sang Gil Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Carotenoids, inflammation, and oxidative stress—implications of cellular signaling pathways and relation to chronic disease prevention

(2014) Anouk Kaulmann et al.   NUTRITION RESEARCH

Luteolin and luteolin-7-O-glucoside strengthen antioxidative potential through the modulation of Nrf2/MAPK mediated HO-1 signaling cascade in RAW 264.7 cells

(2013) Young Sun Song et al.   FOOD AND CHEMICAL TOXICOLOGY

First Evidence for the Anti-inflammatory Activity of Fucoxanthin in High-Fat-Diet-Induced Obesity in Mice and the Antioxidant Functions in PC12 Cells

(2013) Cong-ping Tan et al.   INFLAMMATION

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

(2013) Stacey Ruiz et al.   KIDNEY INTERNATIONAL

Antioxidant effects of fucoxanthin rich powder in rats fed with high fat diet

(2013) Ae Wha Ha et al.   Nutrition Research and Practice

Obesity-Related Metabolic Syndrome: Mechanisms of Sympathetic Overactivity

(2013) Maria Paola Canale et al.   International Journal of Endocrinology

Anti-inflammatory effect of fucoxanthin derivatives isolated from Sargassum siliquastrum in lipopolysaccharide-stimulated RAW 264.7 macrophage

(2012) Soo-Jin Heo et al.   FOOD AND CHEMICAL TOXICOLOGY

Fucoxanthin content and antioxidant properties of Undaria pinnatifida

(2012) Adah Fung et al.   FOOD CHEMISTRY

Pharmacokinetics of fucoxanthinol in human plasma after the oral administration of kombu extract

(2011) Takashi Hashimoto et al.   BRITISH JOURNAL OF NUTRITION

Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages

(2010) Kil-Nam Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages

(2010) Soo-Jin Heo et al.   FOOD AND CHEMICAL TOXICOLOGY

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Keto-Carotenoids Are the Major Metabolites of Dietary Lutein and Fucoxanthin in Mouse Tissues

(2010) Lina Yonekura et al.   JOURNAL OF NUTRITION

The distribution and accumulation of fucoxanthin and its metabolites after oral administration in mice

(2009) Takashi Hashimoto et al.   BRITISH JOURNAL OF NUTRITION

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

(2009) Jiyoung Kim et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Repression of proinflammatory gene expression by lipid extract of Nostoc commune var sphaeroides Kützing, a blue-green alga, via inhibition of nuclear factor-κB in RAW 264.7 macrophages

(2008) Young-Ki Park et al.   NUTRITION RESEARCH