Article
Biochemistry & Molecular Biology
Chiu-Ya Lin, Kun-Yun Yeh, Hsin-Hung Lai, Guor Mour Her
Summary: In this study, a novel agrp promoter was expressed in the zebrafish genome to observe a decline in appetite and growth. The findings demonstrate that AgRP is a critical regulator of neuronal signaling for zebrafish appetite and energy intake control.
Article
Biochemistry & Molecular Biology
Roldan Medina de Guia, Anna S. Hassing, Tao Ma, Kaja Plucinska, Birgitte Holst, Zach Gerhart-Hines, Brice Emanuelli, Jonas T. Treebak
Summary: Deletion of Nampt in AgRP neurons causes progressive neurodegeneration and impairs responses to fasting and ghrelin in a context-dependent manner.
Article
Endocrinology & Metabolism
Min-Chel Kang, Ji A. Seo, Hyon Lee, Aykut Uner, Won-Mo Yang, Kellen Cristina da Cruz Rodrigues, Hyun Jeong Kim, Wendy Li, John N. Campbell, Yossi Dagon, Young-Bum Kim
Summary: The study found that deficiency of LRP1 in GABAergic neurons leads to obesity due to increased food intake, decreased energy expenditure, and reduced locomotor activity. This results in higher levels of leptin and insulin, without changes in body weight. LRP1 in GABAergic neurons does not impact leptin action, and the signaling pathway modulates food intake and energy expenditure independently of leptin signaling and AgRP neurons.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Cell Biology
Chang Woo Chae, Jee Hyeon Yoon, Jae Ryong Lim, Ji Yong Park, Ji Hyeon Cho, Young Hyun Jung, Gee Euhn Choi, Hyun Jik Lee, Ho Jae Han
Summary: Lysosomal dysfunction caused by high glucose leads to the accumulation of A beta and p-MAPT/tau, which may contribute to the pathogenesis of diabetes-associated Alzheimer's disease. TRIM16 restores lysophagy and inhibits the accumulation of A beta and p-MAPT/tau induced by high glucose, providing a potential target for inhibiting the development of diabetes-associated Alzheimer's disease.
Article
Endocrinology & Metabolism
Karl Vivot, Gergoe Meszaros, Evanthia Pangou, Zhirong Zhang, Mengdi Qu, Eric Erbs, Gagik Yeghiazaryan, Mar Quinones, Erwan Grandgirard, Anna Schneider, Etienne Clauss-Creusot, Alexandre Charlet, Maya Faour, Claire Martin, Fedor Berditchevski, Izabela Sumara, Serge Luquet, Peter Kloppenburg, Ruben Nogueiras, Romeo Ricci
Summary: The protein kinase CaMK1D acts on AgRP/NPY neurons to promote ghrelin's effects in mediating food intake in male mice. Ghrelin stimulation activates CaMK1D and its lack reduces the response to ghrelin, leading to decreased body weight gain and protection against high-fat-diet-induced obesity. CaMK1D links ghrelin action to transcriptional control of orexigenic neuropeptide availability in AgRP neurons.
Article
Endocrinology & Metabolism
Taylor Landry, Daniel Shookster, Alec Chaves, Katrina Free, Tony Nguyen, Hu Huang
Summary: Recent research has shown that aerobic exercise plays an important role in modulating the activity of hypothalamic neurons related to appetite, but most of these studies have been conducted on male rodents. This study aimed to investigate the effects of acute treadmill exercise on hypothalamic neuron populations involved in regulating appetite in female mice. The results demonstrated that moderate to high intensity exercise increased food intake and stimulated the activity of certain appetite-regulating neurons in the hypothalamus of female mice.
JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Taylor Landry, Daniel Shookster, Alec Chaves, Katrina Free, Tony Nguyen, Hu Huang
Summary: Aerobic exercise plays a significant role in modulating neurons involved in appetite regulation, with high intensity exercise potentially suppressing food intake through POMC neuron excitation. Additionally, pre-exercise energy status can differentially affect post-exercise feeding behavior and hypothalamic neuron activity, shedding light on inconsistent results in weight loss intervention studies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Juan Han, Xiaofang Liang, Yanzhi Guo, Xiaoliang Wu, Ziqi Li, Tiannuo Hong
Summary: This article investigates the role of AgRP in Japanese seabass and its regulatory function and mechanism in appetite and energy homeostasis. The research indicates that AgRP plays a significant role in fish feeding behavior, particularly in response to glucose in plant proteins.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Hyeyoon Eo, Seong Hye Kim, In Gyoung Ju, Eugene Huh, Sinyeon Kim, Jin Gyu Choi, Se Woong Kim, Miwon Son, Myung Sook Oh
Summary: Type 2 diabetes mellitus (T2DM) is a major global public health issue that is closely associated with the development of other chronic diseases. Binge eating disorder is prevalent in T2DM patients and worsens insulin resistance and metabolic challenges. This study aimed to investigate the potential of longan fruit extract (LE) supplementation in improving glucose homeostasis and binge eating disorder in T2DM. The results showed that LE supplementation ameliorated fasting blood glucose levels, reduced fat accumulation, improved glucose tolerance and insulin sensitivity in T2DM mice. LE supplementation also decreased food consumption, possibly through the suppression of hypothalamic endoplasmic reticulum (ER) stress. These findings suggest that LE could be a potential nutraceutical for improving T2DM and satiety issues in patients.
FRONTIERS IN NUTRITION
(2023)
Article
Developmental Biology
Devynn Hummel, Alexandria Becks, Hongsheng Men, Elizabeth C. Bryda, Derrick M. Glasco, Anand Chandrasekhar
Summary: In the developing hindbrain, Celsr1 suppresses chemoattraction towards Wnt5a in r3, thereby inhibiting the rostral migration of facial branchiomotor (FBM) neurons.
Article
Endocrinology & Metabolism
Caroline E. Geisler, Meghan P. Antonellis, Wolfgang Trumbauer, Jennifer A. Martin, Tamer Coskun, Ricardo J. Samms, Matthew R. Hayes
Summary: This study aims to investigate the role of GIPR and GLP-1R agonists in regulating palatable food intake and specific macronutrient preferences. The results show that GLP-1R and dual GIPR/GLP-1R agonist therapies can decrease preference for high-caloric, high-fat foods, which may contribute to weight loss success.
DIABETES OBESITY & METABOLISM
(2023)
Article
Psychology, Biological
Rachel A. Ross, Angela Kim, Priyanka Das, Yan Li, Yong Kee Choi, Andy Thompson, Ella Douglas, Siva Subramanian, Kat Ramos, Kathryn Callahan, Vadim Y. Bolshakov, Kerry J. Ressler
Summary: A novel population of MC4R-expressing neurons in the infralimbic region of the prefrontal cortex is found to be associated with food intake and body weight regulation in male mice. These neurons receive input from melanocortinergic neurons and project to regions involved in appetitive responses to food-related stimuli.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jutta Margraf-Stiksrud, Klaus Pieper, Renate Deinzer
Summary: The study suggests that the simplified version of MSI constructed based on the principle of item reduction from original data is useful and valid in oral health-related research, saving time and simplifying the economic and reliable assessment of sugar intake.
Article
Allergy
Chihiro Ushiroda, Tomohisa Takagi, Nobuo Fuke, Katsura Mizushima, Yasuko Hirai, Yasuki Higashimura, Akihito Harusato, Kazuhiro Kamada, Kazuhiko Uchiyama, Takeshi Ishikawa, Koichi Aizawa, Hiroyuki Suganuma, Yoshito Itoh, Yuji Naito
Summary: The study showed that lycopene has the potential to increase the number of colonic Tregs, alleviate allergic symptoms, and suppress the proliferation of allergic-related cells.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Aya Sato, Fumiaki Kojima, Toru Hayashi, Shiho Arichi, Yoshihiro Maruo, Hitoshi Ishibashi, Kei Eto
Summary: In this study, it was found that XE991, a potent and selective Kv7 (KCNQ) channel inhibitor, can inhibit nicotinic responses in intracardiac ganglion neurons. This drug reduces nicotine-induced neuronal excitation by suppressing the nicotine-induced current and intracellular calcium concentration elevation.
PHARMACOLOGICAL REPORTS
(2022)
Review
Neurosciences
Michael Lutter, Anna E. Croghan, Huxing Cui
BIOLOGICAL PSYCHIATRY
(2016)
Article
Neurosciences
Hector De Jesus-Cortes, Yuan Lu, Rachel M. Anderson, Michael Z. Khan, Varun Nath, Latisha McDaniel, Michael Lutter, Jason J. Radley, Andrew A. Pieper, Huxing Cui
Article
Genetics & Heredity
Deng-Fu Guo, Huxing Cui, Qihong Zhang, Donald A. Morgan, Daniel R. Thedens, Darryl Nishimura, Justin L. Grobe, Val C. Sheffield, Kamal Rahmouni
Review
Endocrinology & Metabolism
Huxing Cui, Miguel Lopez, Kamal Rahmouni
NATURE REVIEWS ENDOCRINOLOGY
(2017)
Review
Peripheral Vascular Disease
Lisa L. Morselli, Kristin E. Claflin, Huxing Cui, Justin L. Grobe
CURRENT HYPERTENSION REPORTS
(2018)
Review
Biochemistry & Molecular Biology
Kenji Saito, Huxing Cui
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Correction
Endocrinology & Metabolism
Balyssa B. Bell, Shannon M. Harlan, Donald A. Morgan, Deng-Fu Guo, Huxing Cui, Kamal Rahmouni
MOLECULAR METABOLISM
(2018)
Article
Multidisciplinary Sciences
Michael Lutter, Ethan Bahl, Claire Hannah, Dabney Hofammann, Summer Acevedo, Huxing Cui, Carrie J. McAdams, Jacob J. Michaelson
Article
Endocrinology & Metabolism
Kenji Saito, Kevin C. Davis, Donald A. Morgan, Brandon A. Toth, Jingwei Jiang, Uday Singh, Eric D. Berglund, Justin L. Grobe, Kamal Rahmouni, Huxing Cui
Article
Cardiac & Cardiovascular Systems
Jingwei Jiang, Donald A. Morgan, Huxing Cui, Kamal Rahmouni
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Article
Endocrinology & Metabolism
Uday Singh, Jingwei Jiang, Kenji Saito, Brandon A. Toth, Jacob E. Dickey, Samuel R. Rodeghiero, Yue Deng, Guorui Deng, Baojian Xue, Zhiyong Zhu, Leonid V. Zingman, Joel C. Geerling, Huxing Cui
Summary: The PVNMC4R+ neurons project broadly to brain regions involved in feeding, neuroendocrine, and autonomic control, while receiving monosynaptic input mainly from other hypothalamic nuclei and circumventricular organs. Activation of PVNMC4R+ neurons leads to suppression of feeding and physiological changes in cardiovascular and thermoregulatory functions, accompanied by acute transient hyperactivity and rest-like behavior.
MOLECULAR METABOLISM
(2022)
Review
Cell Biology
Kenji Saito, Huxing Cui
Summary: The importance of estrogenic signaling in various biological processes has been well-documented. Estrogen receptor alpha (ER alpha) is a major mediator of cellular estrogenic signaling. The regulation of ER alpha gene transcription, splicing, and expression is complex, involving multiple exons and post-translational modifications. These variations have tissue-specific expression and can mediate different aspects of ER alpha signaling. The understanding of these variations in normal physiology is limited, and more studies are needed.
Review
Physiology
Jingwei Jiang, Huxing Cui, Kamal Rahmouni
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2017)
Article
Neurosciences
Michael Lutter, Michael Z. Khan, Kenji Satio, Kevin C. Davis, Ian J. Kidder, Latisha McDaniel, Benjamin W. Darbro, Andrew A. Pieper, Huxing Cui
BIOLOGICAL PSYCHIATRY
(2017)