Saturated fatty acids entrap PDX1 in stress granules and impede islet beta cell function

E2f8 and Dlg2 genes have independent effects on impaired insulin secretion associated with hyperglycaemia

(2020) Chieh-Hsin Yang et al.   DIABETOLOGIA

Stress granule: a promising target for cancer treatment

(2019) Xiaomeng Gao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Loss of p53 Sensitizes Cells to Palmitic Acid-Induced Apoptosis by Reactive Oxygen Species Accumulation

(2019) Guowu Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Palmitic acid induces ceramide accumulation, mitochondrial protein hyperacetylation, and mitochondrial dysfunction in porcine oocytes†

(2018) Nobuhiko Itami et al.   BIOLOGY OF REPRODUCTION

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

(2018) Ke Zhang et al.   CELL

Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes

(2018) Yoon S. Oh et al.   Frontiers in Endocrinology

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

(2017) Daniel J. Apicco et al.   NATURE NEUROSCIENCE

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

(2017) Miriam Cnop et al.   Molecular Metabolism

Involvement of ER stress, PI3K/AKT activation, and lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis

(2017) Han-Shui Hsu et al.   Scientific Reports

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

(2016) Saumya Jain et al.   CELL

Mechanistic insights into mammalian stress granule dynamics

(2016) Marc D. Panas et al.   JOURNAL OF CELL BIOLOGY

Principles and Properties of Stress Granules

(2016) David S.W. Protter et al.   TRENDS IN CELL BIOLOGY

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

(2016) Tara Vanderweyde et al.   Cell Reports

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

(2015) Ke Zhang et al.   NATURE

Endoplasmic reticulum stress increases AT1R mRNA expression via TIA-1-dependent mechanism

(2015) Michael Backlund et al.   NUCLEIC ACIDS RESEARCH

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA

(2015) A. C. Woerner et al.   SCIENCE

Phosphoinositide 3-kinase-δ regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress

(2015) Kyung Sun Lee et al.   THORAX

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

(2015) Carmela Sidrauski et al.   eLife

Pathological stress granules in Alzheimer’s disease

(2014) Peter E.A. Ash et al.   BRAIN RESEARCH

Phase I dose-escalation study of buparlisib (BKM120), an oral pan-class I PI3K inhibitor, in Japanese patients with advanced solid tumors

(2014) Yuichi Ando et al.   CANCER SCIENCE

Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue

(2014) Melanie Vanessa Heck et al.   NEUROGENETICS

Phosphoinositide 3-Kinases Upregulate System xc− via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

(2013) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

(2013) Mani Ramaswami et al.   CELL

Systematic Analysis of Donor and Isolation Factor's Impact on Human Islet Yield and Size Distribution

(2013) Y. Wang et al.   CELL TRANSPLANTATION

Stress granules as crucibles of ALS pathogenesis

(2013) Yun R. Li et al.   JOURNAL OF CELL BIOLOGY

Inactivation of specific β cell transcription factors in type 2 diabetes

(2013) Shuangli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

(2013) Hyung-Jun Kim et al.   NATURE GENETICS

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

Knockdown of T-cell intracellular antigens triggers cell proliferation, invasion and tumour growth

(2011) José M. Izquierdo et al.   BIOCHEMICAL JOURNAL

The influence of major dietary fatty acids on insulin secretion and action

(2010) Sergio López et al.   CURRENT OPINION IN LIPIDOLOGY

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

(2010) Andrew C. Elden et al.   NATURE

Fatty acids and β-cell toxicity

(2009) Noel G Morgan   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload

(2009) A. M. Preston et al.   DIABETOLOGIA

Depletion of T-cell intracellular antigen proteins promotes cell proliferation

(2009) Raquel Reyes et al.   GENOME BIOLOGY

The islet β-cell: fuel responsive and vulnerable

(2008) Christopher J. Nolan et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM