Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice

Diverse mechanisms for inflammasome sensing of cytosolic bacteria and bacterial virulence

(2016) Yue Zhao et al.   CURRENT OPINION IN MICROBIOLOGY

Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium

(2015) Youssef Aachoui et al.   Cell Host & Microbe

The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines

(2015) Arthur V Hauenstein et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium

(2015) Vivien I. Maltez et al.   IMMUNITY

The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus

(2015) Yue Zhao et al.   IMMUNOLOGICAL REVIEWS

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

(2015) L. Zhang et al.   SCIENCE

Structural and biochemical basis for induced self-propagation of NLRC4

(2015) Z. Hu et al.   SCIENCE

Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa

(2014) Mikael E. Sellin et al.   Cell Host & Microbe

Molecular Basis for Specific Recognition of Bacterial Ligands by NAIP/NLRC4 Inflammasomes

(2014) Jeannette L. Tenthorey et al.   MOLECULAR CELL

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Shigella Type III Secretion Protein MxiI Is Recognized by Naip2 to Induce Nlrc4 Inflammasome Activation Independently of Pkcδ

(2014) Shiho Suzuki et al.   PLoS Pathogens

Detection of cytosolic bacteria by inflammatory caspases

(2013) Jon A Hagar et al.   CURRENT OPINION IN MICROBIOLOGY

Cutting Edge: Mouse NAIP1 Detects the Type III Secretion System Needle Protein

(2013) M. Rayamajhi et al.   JOURNAL OF IMMUNOLOGY

NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen

(2013) S Nordlander et al.   Mucosal Immunology

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

(2013) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Integrated Chip for the High-Throughput Synthesis of Transcription Activator-like Effectors

(2012) Zhao Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

(2012) Jakob von Moltke et al.   NATURE

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota

(2012) Janelle S Ayres et al.   NATURE MEDICINE

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

(2008) Karla L Lightfield et al.   NATURE IMMUNOLOGY